In 2017,Asian Journal of Chemistry included an article by Gilbile, Rohidas; Bhavani, Ram; Vyas, Ritu. Safety of Methyl 1-methyl-1H-pyrazole-4-carboxylate. The article was titled 《Evaluation of synthesis of methyl 3-chloro-5-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate using green metrics》. The information in the text is summarized as follows:
A modified synthesis of Me 3-chloro-5-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate (halosulfuron) was described. The merits of the synthesis were (i) one pot chlorination of Me 1-methyl-1H-pyrazole-4-carboxylate in presence of sulfuryl chloride resulting in Me 3,5-dichloro-1-methyl-1H-pyrazole-4-carboxylate (ii) conversion of 3-chloro-5-mercapto-1-methyl-1H-pyrazole-4-carboxylate to 3-chloro-1-methyl-5-sulfamoylpyrazole-4-carboxylate under mild reaction conditions utilizing tetra-Bu ammonium chloride, N-chlorosuccinimide and ammonium carbonate (iii) condensation of sulfonamide with carbamate by microwave irradiation Efforts were made to calculate, atom economy, reaction mass efficiency and E-factor for all the reaction steps involved in the synthesis of halosulfuron. The E-factor values in step 2 and step 4 reaction was lower, indicating that these reactions were greener (generation of less waste) when compared to the remaining steps in the synthesis. The experimental process involved the reaction of Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2Safety of Methyl 1-methyl-1H-pyrazole-4-carboxylate)
Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Safety of Methyl 1-methyl-1H-pyrazole-4-carboxylate
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics