Mills, L. Reginald; Graham, Joshua M.; Patel, Purvish; Rousseaux, Sophie A. L. published the artcile< Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation>, Related Products of 13788-92-6, the main research area is benzonitrile preparation; aryl halide phenol methyl phenyl malononitrile reductive cyanation; nickel catalyst.
Herein, Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl(pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-Ph malononitrile (MPMN) is reported. MPMN is a bench-stable, carbon-bound electrophilic CN reagent that does not release cyanide under the reaction conditions. A variety of medicinally relevant benzonitriles can be made in good yields. Addition of NaBr to the reaction mixture allows for the use of more challenging aryl electrophiles such as aryl chlorides, tosylates, and triflates. Mechanistic investigations suggest that NaBr plays a role in facilitating oxidative addition with these substrates.
Journal of the American Chemical Society published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Related Products of 13788-92-6.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics