Formula: C4H3F3N2In 2012 ,《Diversification of pyrazoles by microwave-assisted ligand free copper catalyzed N-arylation》 appeared in Bulletin of the Korean Chemical Society. The author of the article were Suh, Jeehee; Kang, Hee Sung; Kim, Ji-Eun; Yum, Eul Kgun. The article conveys some information:
Simple and efficient N-arylation of pyrazoles was achieved using microwave-assisted catalytic Cu reactions without organic ligands and with short reaction times. The N-arylation of pyrazole could be extended to various substituted pyrazoles and aryl halides. Yields of N-arylpyrazoles were highly dependent on the steric and electronic effects of the pyrazole substituents. Further functionalization of N-arylated iodopyrazoles in Cu- and Pd-catalyzed coupling reactions exhibited promising results for the diversification of pyrazoles. In the experiment, the researchers used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Formula: C4H3F3N2)
3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C4H3F3N2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics