Electric Literature of C4H3F3N2In 2010 ,《A novel series of positive modulators of the AMPA receptor: Discovery and structure based hit-to-lead studies》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Jamieson, Craig; Basten, Stephanie; Campbell, Robert A.; Cumming, Iain A.; Gillen, Kevin J.; Gillespie, Jonathan; Kazemier, Bert; Kiczun, Michael; Lamont, Yvonne; Lyons, Amanda J.; MacLean, John K. F.; Moir, Elizabeth M.; Morrow, John A.; Papakosta, Marianthi; Rankovic, Zoran; Smith, Lynn. The article conveys some information:
Starting from an HTS derived hit 1, application of biostructural data facilitated rapid optimization to lead 22 (I), a novel AMPA receptor modulator. This is the first demonstration of how structure based drug design can be exploited in an optimization program for a glutamate receptor. In the part of experimental materials, we found many familiar compounds, such as 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Electric Literature of C4H3F3N2)
3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Electric Literature of C4H3F3N2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics