Nemec, Vaclav’s team published research in Angewandte Chemie, International Edition in 2019 | CAS: 1258323-45-3

Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate(cas: 1258323-45-3) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application In Synthesis of Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate

In 2019,Angewandte Chemie, International Edition included an article by Nemec, Vaclav; Hylsova, Michaela; Maier, Lukas; Flegel, Jana; Sievers, Sonja; Ziegler, Slava; Schroeder, Martin; Berger, Benedict-Tilman; Chaikuad, Apirat; Valcikova, Barbora; Uldrijan, Stjepan; Drapela, Stanislav; Soucek, Karel; Waldmann, Herbert; Knapp, Stefan; Paruch, Kamil. Application In Synthesis of Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate. The article was titled 《Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway》. The information in the text is summarized as follows:

Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic sequences based on chemoselective metal-mediated couplings, including assembly of the furo[3,2-b]pyridine scaffold by copper-mediated oxidative cyclization. Optimization of the subseries containing 3,5-disubstituted furo[3,2-b]pyridines, e.g. I, afforded potent, cell-active, and highly selective inhibitors of CLKs. Profiling of the kinase-inactive subset of 3,5,7-trisubstituted furo[3,2-b]pyridines, e.g. II, revealed sub-micromolar modulators of the Hedgehog pathway. The experimental process involved the reaction of Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate(cas: 1258323-45-3Application In Synthesis of Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate)

Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate(cas: 1258323-45-3) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application In Synthesis of Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics