HPLC of Formula: 474432-62-7On March 15, 2010, Goble, Stephen D.; Wang, Liping; Howell, K. Lulu; Bansal, Alka; Berger, Richard; Brockunier, Linda; Di Salvo, Jerry; Feighner, Scott; Harper, Bart; He, Jiafang; Hurley, Amanda; Hreniuk, Donna; Parmee, Emma; Robbins, Michael; Salituro, Gino; Sanfiz, Anthony; Streckfuss, Eric; Watkins, Eloisa; Weber, Ann E.; Struthers, Mary; Edmondson, Scott D. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Heterocyclic acetamide and benzamide derivatives as potent and selective β3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles》. The article mentions the following:
A series of amide derived β3-adrenergic receptor (AR) agonists is described. The discovery and optimization of several series of compounds derived from 1 (I), is used to lay the SAR foundation for second generation β3-AR agonists for the treatment of overactive bladder. In addition to this study using Pyrazolo[1,5-a]pyridine-7-carboxylic acid, there are many other studies that have used Pyrazolo[1,5-a]pyridine-7-carboxylic acid(cas: 474432-62-7HPLC of Formula: 474432-62-7) was used in this study.
Pyrazolo[1,5-a]pyridine-7-carboxylic acid(cas: 474432-62-7) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. HPLC of Formula: 474432-62-7
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics