In 2018,International Journal of Molecular Sciences included an article by Dago, Camille D.; Le Maux, Paul; Roisnel, Thierry; Brigaudeau, Christophe; Bekro, Yves-Alain; Mignen, Olivier; Bazureau, Jean-Pierre. Related Products of 20154-03-4. The article was titled 《Preliminary structure-activity relationship (SAR) of a novel series of pyrazole SKF-96365 analogues as potential store-operated calcium entry (SOCE) inhibitors》. The information in the text is summarized as follows:
From a series of [β-(phenylalkoxy)-(phenethyl)]-1H-pyrazolium hydrochloride as new analogs of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE)(IC50 25 μM) on the PLP-B lymphocyte cell line. A successful resolution of (±) 1-phenyl-2-(1H-pyrazol-1-yl)ethan-1-ol was developed by using the method of “”half-concentration”” in the presence of (+)-(1S)- or (-)-(1R)-CSA. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Related Products of 20154-03-4)
3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Related Products of 20154-03-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics