Day: November 2, 2022

On September 30, 2012, Siddhartha, Tarun; Mithilesh; Sharma, Raju; Chawla, Pooja; Saraf, S. K. published an article.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the article was Syntheses and antioxidant screening of pyrazole-4-carboxaldehyde derivatives. And the article contained the following:

Pyrazole-4-carboxaldehydes were synthesized by AcOH-mediated condensation of aryl Me ketones with phenylhydrazines in EtOH to afford the corresponding phenylhydrazones. Subsequent reaction with 2 equiv DMF-POCl3 adduct (Vilsmeier Haack reagent) in DMF at 60-70° for 6 h afforded immonium perchlorates. Further, alk. hydrolysis (NaOH) afforded pyrazole-4-carboxaldehydes. All the synthesized compounds were screened for antioxidant activity. In a ferric reducing power assay, increased absorbance of the compounds with concentration indicates increased reducing power. Compounds with higher concentrations showed a higher reducing power. The reducing power showed good linear relation (R2) in both standard as well as in the newly prepared compounds Thus, the compounds have antioxidant activity. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to phenylhydrazone vilsmeier haack cyclization formylation, pyrazolecarboxaldehyde preparation antioxidant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On March 1, 2007, Arora, Nidhi; Billedeau, Roland Joseph; Dewdney, Nolan James; Gabriel, Tobias; Goldstein, David Michael; O’Yang, Counde; Soth, Michael; Trejo-Martin, Teresa Alejandra published a patent.Recommanded Product: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine The title of the patent was Preparation of fused pyrazole derivatives as P38 MAP kinase inhibitors. And the patent contained the following:

The title fused pyrazole derivatives are prepared as p38 MAP kinase inhibitors for the treatment of p38-mediated diseases. For example, the compound I was prepared in a multi-step synthesis. I inhibited p38 MAP kinase with IC50 of 0.001 μM in vitro. Formulations containing the title compound as an active ingredient were also described. The experimental process involved the reaction of 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(cas: 85426-79-5).Recommanded Product: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

The Article related to preparation pyrazolo pyrimidine pyridine p38 map kinase inhibitor, formulation treatment arthritis human, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On August 12, 1975, Wikel, James H. published a patent.COA of Formula: C11H9N3O4 The title of the patent was 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters. And the patent contained the following:

MeO2CCO2Me was treated with MeCOC6H4NO2-2 and the o-O2NC6H4COCH2COCO2Et cyclized with H2NNH2 to give I (R = NO2), which was reduced to I (R = NH2). At 1-200 mg/kg I (R = NH2) was a complement inhibitor. The experimental process involved the reaction of Methyl 3-(2-nitrophenyl)-1H-pyrazole-5-carboxylate(cas: 57446-04-5).COA of Formula: C11H9N3O4

The Article related to complement inhibitor aminophenylpyrazolecarboxylate, pyrazolecarboxylate aminophenyl complement inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.COA of Formula: C11H9N3O4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On December 20, 2019, Xu, Zichen; Wei, Wanguo; Fang, Xianjie; Liu, Rufeng; Yi, Mingyue; Zhou, Chenglong; Liu, Jie published a patent.Computed Properties of 1187582-58-6 The title of the patent was Preparation method of N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide as androgen receptor antagonist. And the patent contained the following:

The invention relates to a process for the preparation of N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide as androgen receptor antagonist. For instance, Suzuki reaction of 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzonitrile with 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole followed by deprotection, N-alkylation with N-Boc-L-alaninol, amidation with 5-acetyl-1H-pyrazole-3-carboxylic acid Et ester, and reduction to give N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide. The experimental process involved the reaction of 5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole(cas: 1187582-58-6).Computed Properties of 1187582-58-6

The Article related to chlorocyanophenyl pyrazolylmethylethylhydroxyethyl pyrazolecarboxamide preparation suzuki alkylation amidation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 1187582-58-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On September 30, 2002, Vovk, M. V.; Mel’nichenko, N. V.; Chornous, V. A.; Bratenko, M. K. published an article.Formula: C20H14N2O The title of the article was Intramolecular cyclization of 4-isocyanato-3-(2-naphthyl)-1-phenylpyrazole under friedel-crafts reaction conditions. And the article contained the following:

4-Isocyanato-3-(2-naphthyl)-1-phenylpyrazole cyclized under the influence of AlCl3 to give 2H-benzo-[h]pyrazolo[4,3-c]isoquinoline. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Formula: C20H14N2O

The Article related to isocyanatonaphthylphenylpyrazole intramol cyclization friedel crafts condition, benzopyrazoloisoquinoline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C20H14N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On September 30, 2016, Diamanti, Eleonora; Bottegoni, Giovanni; Goldoni, Luca; Realini, Natalia; Pagliuca, Chiara; Bertozzi, Fabio; Piomelli, Daniele; Pizzirani, Daniela published an article.Application In Synthesis of 5-Methoxy-1H-pyrazole The title of the article was Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships. And the article contained the following:

Acid ceramidase (a.c.) is a lysosomal cysteine amidase responsible for the cleavage of ceramide into sphingosine, which is then phosphorylated to sphingosine 1-phosphate. AC regulates the intracellular levels of ceramide and sphingosine, and a.c. inhibition may be useful in the treatment of disorders, such as cancer, in which ceramide-mediated signaling may be dysfunctional. Despite their potential exptl. and therapeutic value, the number of available small-mol. inhibitors of a.c. activity remains limited. In the present study is described the discovery of a class of potent pyrazole carboxamide-based a.c. inhibitors, which were identified using the at. property field (APF) approach and developed through systematic SAR studies and in vitro pharmacol. characterization. The best compound of this series inhibits a.c. with nanomolar potency and causes ceramide accumulation and sphingosine depletion in intact G361 proliferative melanoma cells. By expanding the current armamentarium of a.c. inhibitors, these results should facilitate future efforts to unravel the biol. of a.c. and the therapeutic potential of its inhibition. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Application In Synthesis of 5-Methoxy-1H-pyrazole

The Article related to alkyl isocyanate coupling reaction pyrazole, pyrazole carboxamide derivative preparation potent acid ceramidase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On September 30, 2014, Ashok, D.; Ganesh, Arram; Ravi, S.; Lakshmi, B. Vijaya published an article.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the article was Solvent-free microwave assisted synthesis and antimicrobial activity of new 2-{4-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-acryloyl]-phenyl}-isoindole-1,3-diones. And the article contained the following:

A series of new 2-(4-(3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-acryloyl)-phenyl)-isoindole-1,3-diones I (Ar = C6H5, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, 2-naphthyl, etc.) have been synthesized by Claisen-Schmidt condensation of 2-(4-acetylphenyl)-isoindole-1,3-dione with 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehydes in the presence of basic alumina under solvent-free microwave irradiation and conventional heating methods. All the synthesized compounds were screened for their antimicrobial activity. The activity was determined using cup plate agar diffusion method by measuring the zone of inhibition in mm. From the screening studies it is evident that the synthesized compounds I (Ar = Ph, 4-MeC6H4, 2-naphthyl) showed good antibacterial activity and compounds I (Ar = 4-MeOC6H4, 2-naphthyl) showed good antifungal activity against all the tested organisms. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazolyl acryloyl phenylisoindoledione preparation green chem microwave irradiation, solvent free antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On September 30, 1998, Bau, Bernarde; Hofmann, Thorsten; Kloss, Juergen; Neunhoeffer, Hans published an article.Recommanded Product: 5-Methoxy-1H-pyrazole The title of the article was 1,2,3-Triazines. Part 5. Lithiation of 1,2,3-triazines. And the article contained the following:

5-Ethoxy-1,2,3-triazine is mono- and dilithiated and the resulting 4-lithio- and 4,6-dilithio-1,2,3-triazines, were reacted with aromatic aldehydes to give α-hydroxybenzylated derivatives The latter are oxidized to give benzoyl-1,2,3-triazines. Condensation of 4,6-bis(4-methylbenzoyl)-5-ethoxy-1,2,3-triazine, with N2H4 afforded a pyrazolo[4.3-d][1,2,3]triazine, and reaction of benzoyl-1,2,3-triazines with (CH2NH2)2 afforded the 1,2,3-triazino[5,4-e][1,4]diazepines. 4-Methoxy-1,2,3-triazine forms 5- and 6-lithio-4-methoxy-1,2,3-triazine, whose reaction with PhCHO gave 5- and 6-(α-hydroxybenzyl)-4-methoxy-1,2,3-triazine, resp. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Recommanded Product: 5-Methoxy-1H-pyrazole

The Article related to triazine preparation lithiation alkylation, benzoyltriazine preparation, pyrazolotriazine preparation, triazinodiazepine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Recommanded Product: 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Arbaciauskiene, Egle; Martynaitis, Vytas; Krikstolaityte, Sonata; Holzer, Wolfgang; Sackusa, Algirdas published an article in 2011, the title of the article was Synthesis of 3-substituted 1-phenyl-1H-pyrazole-4-carbaldehydes and the corresponding ethanones by Pd-catalyzed cross-coupling reactions.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde And the article contains the following content:

An efficient synthetic route to construct substituted 1-phenyl-1H-pyrazole-4-carboxaldehydes and the corresponding ethanones was described and the synthesis of the target compounds was achieved using 1-phenyl-1H-pyrazol-3-ol as a starting material. Carbon-carbon bond-forming palladium-catalyzed cross-coupling reactions were applied for the functionalization of the intermediate pyrazole triflates [i.e., trifluoromethanesulfonic acid 1-phenyl-1H-pyrazol-3-yl ester derivatives]. The target compounds thus formed included imidazo[4,3-c]pyridine derivatives, 1,3-diphenyl-1H-pyrazole-4-carboxaldehyde, 1-phenyl-3-(3-thienyl)-1H-pyrazole-4-carboxaldehyde, 1-(1,3-diphenyl-1H-pyrazol-4-yl)ethanone, etc. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazolol triflate preparation palladium catalyzed cross coupling, pyrazolecarboxaldehyde preparation, ethanone pyrazolyl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Xu, Li-Li; Zheng, Chang-Ji; Sun, Liang-Peng; Miao, Jing; Piao, Hu-Ri published an article in 2012, the title of the article was Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.Electric Literature of 36640-53-6 And the article contains the following content:

In the present study, a series of 1,3-diarylpyrazole derivatives I [R = (un)substituted Ph, n = 1-5] bearing rhodanine-3-fatty acid moieties were synthesized and their antimicrobial activities were tested against various Gram-pos. and Gram-neg. bacteria. 1,3-Diaryl-4-formylpyrazoles were synthesized as key intermediates following a Vilsmeier-Haack strategy. Several compounds with an MIC of 2 μg/mL exhibited stronger antibacterial activity against the methicillin-resistant Staphylococcus aureus (MRSA) than the controls. None of the compounds showed any activity against Gram-neg. bacteria. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Electric Literature of 36640-53-6

The Article related to pyrazole aryl rhodanine derivative preparation antibacterial, thiazolidinone thioxodiarylpyrazolylmethylene preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Electric Literature of 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics