Day: November 2, 2022

Sirbu, Doina; Diharce, Julien; Martinic, Ivana; Chopin, Nicolas; Eliseeva, Svetlana V.; Guillaumet, Gerald; Petoud, Stephane; Bonnet, Pascal; Suzenet, Franck published an article in 2019, the title of the article was An original class of small sized molecules as versatile fluorescent probes for cellular imaging.Category: pyrazoles-derivatives And the article contains the following content:

An unusual class, compact in size, of fluorescent probes based on pyridazino-1,3a,6a-triazapentalene scaffolds exhibits promising fluorescent properties (quantum yield values up to 73%, large Stokes shifts, emission wavelengths located in the green-yellow range, excellent solubility) with good photostability suitable for optical imaging applications. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Category: pyrazoles-derivatives

The Article related to fluorescent probe cell imaging, Biochemical Methods: Spectral and Related Methods and other aspects.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On June 13, 2013, Houze, Jonathan B.; Dransfield, Paul; Pattaropong, Vatee; Du, Xiaohui; Fu, Zice; Lai, Sujen; Park, Jaehyeon; Jiao, Xianyun; Kohn, Todd J.; Aicher, Thomas Daniel; Boyd, Steven Armen; Bencsik, Josef; Condroski, Kevin Ronald; Hinklin, Ronald Jay; Kraser, Christopher F.; Pratt, Scott; Singh, Ajay; Wenglowsky, Steven Mark; Boys, Mark Laurence; Chicarelli, Mark Joseph; Mohr, Peter J.; Cardozo, Mario G. published a patent.Reference of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol The title of the patent was Urea compounds as GKa activators and their preparation. And the patent contained the following:

The invention relates to urea compounds of formula I, to pharmaceutical compositions comprising the compounds, to a process for making the compounds and to the use of the compounds in the treatment of diseases and disorders that would benefit from activation of glucokinase. Compounds of formula I wherein R1 is H, alkyl, alkenyl, haloalkyl, etc.; R2 is H, alkyl and halo; R3 is H, halo, alkoxycarbonyl, etc.; G is C and N; P is H and LR6; L is O, S, CH2 and CH2O; R6 is aryl aralkyl, heterocyclyl, etc.; and with proviso; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their glucokinase activation activity (data given). The experimental process involved the reaction of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol(cas: 924909-16-0).Reference of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol

The Article related to pyridinyl urea preparation glucokinase activator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of 1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Komatsuda, Masaaki; Suto, Ayane; Kondo, Hiroki Jr; Takada, Hiroyuki; Kato, Kenta; Saito, Bunnai; Yamaguchi, Junichiro published an article in 2022, the title of the article was Ring-opening fluorination of bicyclic azaarenes.HPLC of Formula: 143803-93-4 And the article contains the following content:

Authors have discovered a ring-opening fluorination of bicyclic azaarenes. Upon treatment of bicyclic azaarenes such as pyrazolo[1,5-a]pyridines with electrophilic fluorinating agents, fluorination of the aromatic ring is followed by a ring-opening reaction. Although this overall transformation can be classified as an electrophilic fluorination of an aromatic ring, it is a novel type of fluorination that results in construction of tertiary carbon-fluorine bonds. The present protocol can be applied to a range of bicyclic azaarenes, tolerating azines and a variety of functional groups. Addnl., mechanistic studies and enantioselective fluorination have been examined The experimental process involved the reaction of 4-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 143803-93-4).HPLC of Formula: 143803-93-4

The Article related to pyrazolopyridine bicyclic azaarene ring opening fluorination, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 143803-93-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ricard, Simon; Gagnon, Alexandre published an article in 2016, the title of the article was Tricyclohexylphosphine tetrafluoroborate.Electric Literature of 1028092-65-0 And the article contains the following content:

A review. Preparation, properties and application of tricyclohexylphosphonium tetrafluoroborate as a ligand precursor for various cross-coupling reactions, including decarboxylative cross-coupling, direct arylation of aromatic and heteroaromatic compounds, cyclization, cyclopropane ring opening and other reactions are discussed. The experimental process involved the reaction of 3-Phenyl-1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 1028092-65-0).Electric Literature of 1028092-65-0

The Article related to review tricyclohexyl phosphine tetrafluoroborate preparation ligand precursor, Organometallic and Organometalloidal Compounds: Reviews and other aspects.Electric Literature of 1028092-65-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On October 22, 2020, Lancellotti, Patrizio; Oury, Cecile; Pirotte, Bernard; Musumeci, Lucia; Jacques, Nicolas; Goffin, Eric published a patent.Recommanded Product: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine The title of the patent was New pyrimidine derivatives for prevention and treatment of gram-negative bacterial infection, contamination and fouling. And the patent contained the following:

New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-neg. bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-neg. biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-neg. bacterial infection in a host mammal. The experimental process involved the reaction of 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(cas: 85426-79-5).Recommanded Product: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

The Article related to antibacterial pyrimidine derivative, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On April 11, 2013, Cox, Christopher D.; Beshore, Douglas C.; Kim, June J.; Kuduk, Scott D.; McVean, Carol; Reger, Thomas; Sheen, Justin published a patent.Name: 5-Methoxy-1H-pyrazole The title of the patent was Preparation of 1,3-substituted azetidine PDE10 inhibitors for treatment of CNS disorders. And the patent contained the following:

The present invention is directed to substituted azetidine compounds of general formula I (wherein X1, X2 and X3 independently are CH or N; R is H and C1-6alkyl; R2 is H, (un)substituted O-C1-6alkyl, (un)substituted C1-3haloalkyl, etc.; R3 is NRC(O)R6, C(O)OR6, C(O)NR6R6, and (CH2)nC5-10heterocycle, said heterocycle is optionally substituted; R5 is (CH2)nC6-10 aryl, (CH2)nC5-10 heterocycle, (CH2)nC3-10cycloalkyl, the rings being optionally substituted; R6 is H, (un)substituted C1-6-alkyl, OR, etc.; n = 0-4) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurol. and psychiatric disorders, such as schizophrenia, psychosis or Huntington’s disease, and those associated with striatal hypofunction or basal ganglia dysfunction. Synthetic procedures for preparing I are exemplified. Example compound II was prepared by reacting intermediates 2-(azetidin-3-yl)-1-methyl-1H-benzimidazole and 4-chloro-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine. In a PDE10 inhibition assay, II had a Ki of 2.1 nM. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Name: 5-Methoxy-1H-pyrazole

The Article related to preparation azetidine compound pde10 inhibitor treatment cns disorder, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Name: 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On January 26, 2017, Suzenet, Franck; Sirbu, Doina; Guillaumet, Gerald; Bonnet, Pascal published a patent.Recommanded Product: 5-Methoxy-1H-pyrazole The title of the patent was Preparation of new polyazo heterocyclic compounds and their uses as fluorescent chromophores. And the patent contained the following:

The invention relates to the preparation and use as chromophoric fluorescent of compounds of formula I wherein A1 is N or C(Y1); A2 is N or C(Y2); A3 is N or C(Y3); A4 is N or C(Y4); at least one of A1, A2, A3 and A4 representing N; X1 is N or C(Y5); X2 is N or C(Y6); X3 is N or C(Y7); and Y1, Y2, Y3, Y4, Y5, Y6 and Y7 are in particular selected independently of one another from H, electron-donating groups and electron-withdrawing groups. Example compounds, such as II were prepared by multistep procedures (shown) and evaluated for their photophys. properties (data shown). Compounds I are useful as fluorescent chromophores for detection of mols. of biol. origin. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Recommanded Product: 5-Methoxy-1H-pyrazole

The Article related to polyazo heterocycle preparation fluorescent chromophore biol mol detection probe, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Recommanded Product: 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On January 27, 2017, Suzenet, Franck; Sirbu, Doina; Guillaumet, Gerald; Bonnet, Pascal published a patent.Recommanded Product: 5-Methoxy-1H-pyrazole The title of the patent was Preparation of new polyazo heterocyclic compounds and their uses as fluorescent chromophores. And the patent contained the following:

The invention relates to the preparation and use as chromophoric fluorescent of compounds of formula I wherein A1 is N or C(Y1); A2 is N or C(Y2); A3 is N or C(Y3); A4 is N or C(Y4); at least one of A1, A2, A3 and A4 representing N; X1 is N or C(Y5); X2 is N or C(Y6); X3 is N or C(Y7); and Y1, Y2, Y3, Y4, Y5, Y6 and Y7 are in particular selected independently of one another from H, electron-donating groups and electron-withdrawing groups. Example compounds, such as II were prepared by multistep procedures (shown) and evaluated for their photophys. properties (data shown). Compounds I are useful as fluorescent chromophores for detection of mols. of biol. origin. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Recommanded Product: 5-Methoxy-1H-pyrazole

The Article related to polyazo heterocycle preparation fluorescent chromophore biol mol detection probe, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Recommanded Product: 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Doepp, H.; Doepp, D. published an article in 2004, the title of the article was Product subclass 1: 1,2,3-triazines and phosphorus analogues.Related Products of 215610-30-3 And the article contains the following content:

A review. Methods for preparing triazines and their phosphorus analogs are reviewed including cyclization, ring transformation, aromatization, and substituent modification. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Related Products of 215610-30-3

The Article related to review triazine phosphorus analog preparation cyclization ring transformation aromatization, Heterocyclic Compounds (More Than One Hetero Atom): Reviews and other aspects.Related Products of 215610-30-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On February 10, 2010, Janin, Yves; Guillou, Sandrine published a patent.Application In Synthesis of 5-Methoxy-1H-pyrazole The title of the patent was Preparation of alkoxypyrazoles. And the patent contained the following:

The present invention relates to a process for the preparation of alkoxypyrazoles and new alkoxypyrazole compounds The invention relates to a process for the preparation of alkoxypyrazoles I and their isomers, wherein R1 is (un)substituted alkyl, alkenyl, or alkynyl, etc.; R2 is H, halo, substituted alkyl, alkenyl, or alkynyl; R3 is H, halo, (un)substituted alkyl, or aryl, etc.; R4 is H, (un)substituted alkyl, aryl, or heteroaryl, etc. For instance, heterocyclization of diethylethoxymethylenemalonate with NH2NH2 gave Et 3-ethoxy-1H-pyrazole-4-carboxylate (41%) and 2,3-dihydro-3-oxo-1H-pyrazole-4-carboxylic acid Et ester (37%). The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Application In Synthesis of 5-Methoxy-1H-pyrazole

The Article related to alkoxypyrazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics