Month: November 2022

Fujino, O. published the artcileDetermination of uranium and thorium in apatite minerals by inductively coupled plasma atomic emission spectrometry with solvent extraction separation into diisobutyl ketone, Application In Synthesis of 1691-93-6, the main research area is uranium thorium determination apatite ICP AES.

Determination of the actinide elements (U and Th) in apatite minerals was examined by inductively coupled plasma at. emission spectrometry (ICP-AES) with solvent extraction separation The spectral interference by Ca in the apatite and the neg. interference by the macro-component (Ca phosphate) occurred simultaneously for U and Th. Therefore, after apatite mineral was treated with hot concentrated HNO3, U and Th were separated from Ca phosphate by the solvent extraction method. 1-Phenyl-3-methyl-4-trifluoroacetyl-5-pyrazolone (HPMTFP, pKa=2.56) was used as an extraction reagent. Diisobutyl ketone was selected as the extraction organic solvent. U and Th were quant. extracted over pH 2, and could be separated from the apatite composites. The organic phase was injected directly into the ICP-AES spectrometer. The U and Th contents in apatite minerals from Florida, USA, are 103 ± 2.2 and 8.84 ± 0.19 ppm. These results were quite comparable with those measured with ICP-mass spectrometry (ICP-MS).

Analytica Chimica Acta published new progress about Apatite-group minerals Role: AMX (Analytical Matrix), ANST (Analytical Study). 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Application In Synthesis of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ihara, Hideki published the artcileEasily Attachable and Detachable ortho-Directing Agent for Arylboronic Acids in Ruthenium-Catalyzed Aromatic C-H Silylation, Recommanded Product: 2-(1H-Pyrazol-3-yl)aniline, the main research area is arylboronic ester silylation regioselective pyrazolylaniline ortho directing ruthenium catalyst; silylated boronic ester Suzuki Miyaura coupling arene.

O-C-H silylation of arylboronic acids has been achieved using 2-pyrazol-5-ylaniline as an ortho-directing agent, which was temporarily attached to the boryl group via Ru-catalyzed silylation with hydrosilanes. Condensation products of arylboronic acids with 2-pyrazol-5-ylaniline were prepared in situ and subjected to reaction with triorganosilanes in the presence of RuH2(CO)(PPh3)3 at 135 °C. Regioselective silylation at their ortho-positions proceeded in good yields for phenylboronic acids bearing para-substituents such as chloro, fluoro, Me, methoxy, and trifluoromethyl groups. P-Methoxycarbonyl-substituted phenylboronic acid provided the corresponding silylated product in moderate yield. M-Tolyl- and 2-naphthylboronic acids underwent silylation selectively at the less sterically hindered ortho-positions. The silylated products were utilized in Suzuki-Miyaura coupling, followed either by iodination with ICl or by Tamao oxidation to furnish iodine- or hydroxy-substituted biaryls.

Journal of the American Chemical Society published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (arylboronic acids). 111562-32-4 belongs to class pyrazoles-derivatives, name is 2-(1H-Pyrazol-3-yl)aniline, and the molecular formula is C9H9N3, Recommanded Product: 2-(1H-Pyrazol-3-yl)aniline.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Aromi, Guillem published the artcileA systematic exploration of nickel-pyrazolinato chemistry with alkali metals: New cages from serendipitous assembly, Synthetic Route of 27412-71-1, the main research area is crystal structure alkali metal nickel pyrazolinolato pivalato multinuclear cluster; alkali metal nickel pyrazolinolato pivalato multinuclear cluster preparation structure; magnetic property nickel pyrazolinolato pivalato multinuclear cluster.

The preparation and properties of fourteen novel paramagnetic [NiIIx] aggregates bridged by pivalate, pyrazolinolate and in most cases hydroxide are reported. A rich structural diversity was achieved by changing the nature of the alkali of the base used during the synthesis, leading to the nuclearities [NiII4NaI4] (2, 3, 4), [NiII5NaI4] (5, 6, 7), [NiII5LiI6] (8), [NiII8MI2] [M = K (9, 10), Rb (11, 12), Cs (13, 14)] and [NiII8] (15). All compounds were characterized by single-crystal x-ray diffraction; however, full crystallog. details are given only for the representative mols. [Ni4Na4(fpo)4(piv)8(Hpiv)8] (2), [Ni5Na4(OH)2(mpo)4(piv)8(Hpiv)2(MeCN)2] (5), [Ni5Li6(OH)2(fpo)2(piv)12(Hpiv)4] (8), [Ni8K2(OH)4(ppo)4(piv)10(Hppo)2(Hpiv)2(MeCN)2] (9), [Ni8Rb2(OH)4(ppo)4(piv)10(Hppo)2(Hpiv)2(MeCN)2] (11), [Ni8Cs2(OH)4(ppo)4(piv)10(Hppo)2(Hpiv)2(MeCN)2] (13) and [Ni8(OH)4(mpo)2(PhCH2CO2)10(Hmpo)8] (15), where 5-R-3-pyrazolone [R = Me (Hmpo), Et (Hepo), CF3 (Hfpo), Ph (Hppo)]. Variable-temperature bulk magnetization measurements were performed for each type of complex. The [NiII4NaI4] clusters show intramol. antiferromagnetic coupling and a spin ground state of S = 0. [NiII5NaI4] also display antiferromagnetic superexchange, leading to an S = 1 spin ground state. The mol. with nuclearity [NiII5Li16], in contrast, exhibits ferromagnetic interactions, resulting in the presence of low energy states with high multiplicity, and a spin ground state S > 1. The [NiII8M12] and [NiII8] clusters have the same topol. of spin carriers, which display predominantly antiferromagnetic interactions to yield a diamagnetic ground state. The coupling within these octanuclear NiII clusters is rationalized in terms of the nature of the Ni-O-Ni angles within the core.

Chemistry – A European Journal published new progress about Antiferromagnetic exchange. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Synthetic Route of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Modi, C. K. published the artcileSome novel tetradentate Schiff base complexes VO(IV) and Cu(II) involving fluorinated heterocyclic β-diketones and polymethylene diamines of varying chain length, Category: pyrazoles-derivatives, the main research area is preparation fluoroacetylpyrazolinone alkyldiamine Schiff base transition metal complex; thermal decomposition fluoroacetylpyrazolinone alkyldiamine Schiff base transition metal complex.

The present article describes the synthesis, spectral, coordination and thermal aspects of N,N’-polymethylene bis(1-phenyl-3-methyl-4-trifluoroacetylimino-2-pyrazoline-5-ol)oxovanadium(IV) or copper(II) Schiff base complexes with alkyl backbones ranging from two to four carbons were characterized on the basis of elemental anal., magnetic moments, molar conductivity measurements, spectra (FTIR, ESR, UV-Visible, MS), VPO and thermal studies. The vapor pressure osmometry (VPO) and mass spectral studies indicate that the complexes are monomeric. An ESR study of all these complexes of VO(IV) and Cu(II) are consistent with the square pyramidal and square planar geometries of these metal ions, resp. In addition, the kinetics and thermodn. parameters for the different thermal decomposition steps of the complexes were studied employing Horowitz-Metzger and Freemen-Carroll methods.

Journal of Thermal Analysis and Calorimetry published new progress about Thermal decomposition. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Category: pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kottha, Thirumalaswamy S. published the artcileA Bioisosteric and Scaffold Hopping Approach for the Design and Synthesis of Double Ring Replacement Analogues of 4-Aryl-4H-Chromenes and in silico Tubulin Inhibitor Studies, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one, the main research area is aryl chromene bioisosteric analog preparation green chem tubulin inhibitor.

An eco-friendly reaction protocol was developed for the synthesis of heterocyclic hybrid scaffolds through bioisosteric replacement and scaffold hopping approach. The isosteric analogs of salicylaldehyde were designed, identified/synthesized and employed in a three component reaction to afford bioisosteric analogs of 4-aryl-4H-chromenes. Thus central core swapping of benzene-pyridine/pyrazole ring on 4-aryl-4H-chromenes was achieved under simple one-pot reaction conditions and easy work-up. Docking studies show that almost all the compounds possess good binding affinities at the colchicine binding site of tubulin.

ChemistrySelect published new progress about Gastrointestinal absorption. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Recommanded Product: 5-Phenyl-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Uehara, Akihiro published the artcileA new electrochemical method to study the distribution of weak acids at the aqueous|organic solution interface, Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is electrochem method weak acid distribution aqueous organic solution interface; phenylmethylbenzoylpyrazolone distribution aqueous organic solution interface electrochem method; phenylmethyltrifluoroacetylpyrazolone distribution aqueous organic solution interface electrochem method; thenoyltrifluoroacetone distribution aqueous organic solution interface electrochem method; dichloroethane water interface weak acid distribution electrochem method.

The distribution process of a weak acid, HA, between an aqueous and an organic solution, W and O, was assumed to be the transfers of the dissociation products, H+ and A-, between W and O combined with the associations of H+ and A- in W and O. The transfers were considered to proceed depending on Gibbs energies for the transfer of H+ and A- from W to O, ΔGotr,H+ and ΔGotr,A-, and maintaining electroneutrality in both W and O. Then, a theor. equation was derived for quant. expressions of distribution ratios, D, of species relative to HA between W and O at various pH of W by using ΔGotr,H+ and ΔGotr,A- and acid dissociation constants of HA in W and O, Ka,W and Ka,O. The D calculated by substituting Ka,W, Ka,O, ΔGotr,H+ and ΔGotr,A- determined with the aid of electrochem. methods for those in the derived equation agreed well with D determined by the distribution experiments with W of wide pH range. The HA studied were chelating agents such as 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone, 1-phenyl-3-methyl-4-trifluoroacetyl-5-pyrazolone and thenoyltrifluoroacetone.

Journal of Electroanalytical Chemistry published new progress about Electrolysis (controlled potential-difference). 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Safety of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Squarcialupi, Lucia published the artcileStructural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor, Safety of Methyl 4-amino-1-methyl-1H-pyrazole-3-carboxylate, the main research area is pyrazolopyrimidine derivative preparation A3 adenosine receptor antagonist structure activity; Adenosine receptor antagonists; G-protein-coupled receptors; Ligand-receptor modeling studies; Pyrazolopyrimidines.

In previous research, the authors identified some 7-oxo- and 7-acylamino-substituted pyrazolo[4,3-d]pyrimidine derivatives as potent and selective human (h) A3 adenosine receptor (AR) antagonists. Herein the authors report on the structural refinement of this class of antagonists aimed at achieving improved receptor-ligand recognition. Hence, substituents with different steric bulk, flexibility and lipophilicity (Me, Ar, heteroaryl, CH2Ph) were introduced at the 5- and 2-positions of the bicyclic scaffold of both the 7-oxo and 7-amino derivatives, and acyl residues were appended on the 7-amino group of the latter. All the 2-phenylpyrazolo[4,3-d]pyrimidin-7-amines and 7-acylamines bearing a 4-methoxyphenyl- or a 2-thienyl group at the 5-position showed high hA3 affinity and selectivity. In particular, the 2-phenyl-5-(2-thienyl)-pyrazolo[4,3-d]pyrimidin-7-(4-methoxybenzoyl)amine 25 (Ki = 0.027 nM) is one of the most potent and selective hA3 antagonists reported so far. By using an in silico receptor-driven approach the obtained binding data were rationalized and the mol. bases of the observed hA3 AR affinities were critically described.

European Journal of Medicinal Chemistry published new progress about Adenosine A3 receptor antagonists. 637336-53-9 belongs to class pyrazoles-derivatives, name is Methyl 4-amino-1-methyl-1H-pyrazole-3-carboxylate, and the molecular formula is C6H9N3O2, Safety of Methyl 4-amino-1-methyl-1H-pyrazole-3-carboxylate.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Varma, R. Luxmi published the artcileBis(2-ethylhexyl)-N,N-diethylcarbamoylmethyl phosphonate as a synergist in the extraction of trivalent lanthanides by 1-phenyl-3-methyl-4-trifluoroacetyl-pyrazolone-5, HPLC of Formula: 1691-93-6, the main research area is synergetic extraction trivalent lanthanide.

Synergism in the extraction of trivalent lanthanides such as Nd, Eu, and Lu was investigated by using mixtures of 1-phenyl-3-methyl-4-trifluoroacetyl-pyrazolone-5 (HPMTFP) and bis(2-ethylhexyl)-N,N-diethylcarbamoylmethyl phosphonate (CMP) in chloroform. Lanthanides are found to be extracted from 0.01 mol/dm3 chloroacette medium with HPMTFP as Ln(PMTFP)3 or Ln(PMTFP)3·CMP in the absence or presence of CMP, resp. The equilibrium constants of these synergistic species do not increase monotonically with at. number but have a maximum at Eu. The addition of a synergist, CMP to the metal chelate system not only enhances the extraction efficiency but also improves the selectivities among these trivalent lanthanides. The IR results indicate that CMP acts as a bidentate ligand in these mixed-ligand systems.

Radiochimica Acta published new progress about. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, HPLC of Formula: 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Choi, Young Lok published the artcileDirect Synthesis of Pyrazolo[5,1-a]isoindoles via Intramolecular Palladium-Catalyzed C-H Bond Activation, Related Products of pyrazoles-derivatives, the main research area is halobenzylpyrazole preparation palladium intramol carbon hydrogen activation; pyrazoloisoindole derivative preparation.

An efficient, direct synthesis of pyrazolo[5,1-a]isoindoles, e.g., I, employing a palladium-catalyzed intramol. C-H bond activation of 1-(2-halobenzyl)pyrazoles has been developed. The use of lithium chloride (LiCl) was found to be essential in these reactions, to suppress further C-H bond activation at the C-3 position of pyrazolo[5,1-a]isoindole, when C-3 is unsubstituted. This protocol can be applied to the synthesis of a pyrazolo[5,1-a]isoquinoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-a]isoindole using sequential intra- and intermol. C-H bond activation.

Advanced Synthesis & Catalysis published new progress about Arylation (intramol.). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, Related Products of pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Huang, Chunhui published the artcileLangmuir Film-Forming and Second Harmonic Generation Properties of Lanthanide Complexes, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is LB film lanthanide diketonato hemicyanine; laser radiation generation lanthanide diketonato hemicyanine; lanthanide diketonato hemicyanine preparation lasing film.

Amphiphilic lanthanide complexes were designed and synthesized, in which the lanthanide complex anions act both as the counterions of hemicyanine and as the spacer within a Langmuir-Blodgett (LB) film. Studies on the surface pressure-area (π-A) isotherms of these complexes show that the film-forming properties can be clearly improved if appropriate β-diketone ligands were chosen. The effects of mol. structures of the complexes, including the variation of lanthanide central ions, the structures of β-diketone ligands, and the length of alkyl chains in hemicyanines, on the film-forming properties of the materials are discussed. From 2nd-harmonic generation experiments, the largely enhanced 2nd-order mol. hyperpolarizability of lanthanide complexes with good film-forming properties were obtained compared with the hemicyanine iodide. This effect may be due in part to the local field effect but primarily mol. ordering and ordered segregation of hemicyanine chromophores by the bulky lanthanide complex anions. The charge separation of the hemicyanine chromophores was supported by the crystal structure of a model complex. The homogeneity of the film was verified by low angle x-ray diffraction and also by the linear relation of the absorbance vs. the number of layers of the LB films of a selected complex.

Journal of Physical Chemistry published new progress about Langmuir-Blodgett films. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics