Month: November 2022

Liu, Mingming published the artcileDiscovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis, Computed Properties of 763120-58-7, the publication is Journal of Medicinal Chemistry (2019), 62(20), 9299-9314, database is CAplus and MEDLINE.

In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated for their inhibitory effect by dual luciferase-reporter assay. Based on five rounds of investigation on structure-activity relationships step by step, compound I was discovered as the most active inhibitor (IC₅₀ = 0.32 μM) with no obvious cytotoxicity (CC₅₀ > 50 μM). It effectively attenuated hypoxia-induced HIF-1α protein accumulation and reduced transcription of vascular epidermal growth factor in a dose-dependent manner, which was further demonstrated by its inhibitory potency on capillary-like tube formation, angiogenesis of zebrafish as well as cellular migration and invasion. Importantly, compound I exhibited antimetastatic potency in breast cancer lung metastasis in the mice model, indicating its promising therapeutic potential for prevention and treatment of tumor metastasis. These results definitely merit attention for further rational design of more efficient HIF-1 inhibitors in the future.

Journal of Medicinal Chemistry published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Computed Properties of 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Guo, Jun-ling published the artcileOne-step synthesis and thermal behavior of 1-methyl-3,4,5-trinitropyrazole, Product Details of C4H6N2, the publication is Hanneng Cailiao (2015), 23(3), 304-306, database is CAplus.

1-Methyl-3, 4 ,5-trinitropyrazole (MTNP) as an insensitive energetic compound was one-step synthesized with 1-methylpyrazole via direct nitration using mixture of nitric acid and fuming sulfuric acid for the first time. The structure of MTNP was characterized by IR, NMR, elemental anal., and mass spectrum. The reaction conditions were optimized as following: reaction temperature 90 °C, reaction time 6 h , molar ratio of HNO₃ and fuming sulfuric acid 1 : 8. At this condition, the yield of MTNP can reach up to 15.2%. Thermal behavior of MTNP was studied by DSC. Results show that its decomposition temperature is 272.0 °C, indicating a good heat stability.

Hanneng Cailiao published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Product Details of C4H6N2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Lu, Youcai published the artcileExtraction and Separation of Rare Earths from Nitrate Medium by Mixtures of p-Phosphorylated Calixarene and 1-Phenyl-3-methyl-4-benzoyl-pyrazalone-5, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Chinese Journal of Chemistry (2014), 32(10), 1077-1082, database is CAplus.

The gadolinium extraction by the mixtures of p-phosphorylated calixarene and 1-phenyl-3-methyl-4-benzoyl- pyrazalone-5 from nitrate medium was studied, which indicated an obvious synergistic effect between these two extractants. The extractants exhibit no interaction with each other before the metal extraction Gadolinium(III) was extracted by the species of Ln(PMBP)₂L₂(NO₃) instead of Ln(PMBP)₃·(HPMBP) or Ln(NO₃)₃·2L which are extracted by HPMBP or L alone. Thermodn. functions (ΔG, ΔH, ΔS) were calculated The extraction of other rare earths was also investigated and compared. Possible single rare earth separation was discussed.

Chinese Journal of Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Kang, Quan-Peng published the artcileSymmetric containing-PMBP N₂O₂-donors nickel(II) complexes: Syntheses, structures, Hirshfeld analyses and fluorescent properties, Formula: C17H14N2O2, the publication is Polyhedron (2019), 38-50, database is CAplus.

One mononuclear Ni(II) complex [Ni(L¹)(MeOH)₂]·MeOH (1) and two novel trinuclear Ni(II) complexes [Ni₃(L²)₃(EtOH)₆] (2) and [Ni₃(L²)₃(H₂O)₆] (3) constructed from sym. N₂O₂-donors chelating ligands (H₂L¹ and H₂L²) were synthesized and characterized by elemental analyses, FT-IR, UV-Vis spectra and fluorescence spectra. The structures of all three complexes were confirmed by single crystal x-ray diffraction analyses. Complex 1 includes one Ni(II) atom, one completely deprotonated (L¹)^2- unit and two coordinated methanol mols., and forms an infinite 2D supramol. network via the intermol. hydrogen bonds. While complex 2 or 3 is trinuclear with three Ni(II) atoms, three completely deprotonated (L²)^2- units and six coordinated ethanol or H₂O mols. These self-assembling complexes form different dimensional supramol. structures through inter- and intramol. hydrogen bonds. Hirshfeld surface analyses for complexes 1, 2 and 3 were mapped with various functions and further quantification of intermol. interactions was made through the generation of 2D fingerprint plots. In addition, the fluorescence titration experiments were used to characterize fluorescence properties of complexes 1 and 2.

Polyhedron published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Formula: C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Yu, Lingbo published the artcileSynthesis of 1-alkyl-4-amino-5-pyrazolecarboxylate and ethyl 1-alkyl-5-amino-4-pyrazolecarboxylate, Product Details of C7H11N3O2, the publication is Zhongguo Haiyang Daxue Xuebao, Ziran Kexueban (2006), 36(3), 54-58, database is CAplus.

Synthetic routes to two kinds of substituted pyrazole derivatives were designed based on an anal. of their structural features. The methods for preparing such heterocyclic intermediates, including an N-alkylation reaction condition are researched. The structures of 1-cyclopentyl-4-nitro-5-propyl-1H-pyrazole-3-carboxylic acid Et ester and 1-cyclopentyl-4-nitro-3-propyl-1H-pyrazole-5-carboxylic acid Et ester were identified by HMBC and INEPT NMR techniques.

Zhongguo Haiyang Daxue Xuebao, Ziran Kexueban published new progress about 23286-70-6. 23286-70-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Ester, name is Ethyl 5-amino-3-methyl-1H-pyrazole-4-carboxylate, and the molecular formula is C15H21BO3, Product Details of C7H11N3O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Xu, Sheng-jie published the artcileSynthesis and cytotoxicity of some pyrazolic compounds, Name: 4-(1H-Pyrazol-4-yl)pyridine, the publication is Guangzhou Huagong (2012), 40(24), 47-48, database is CAplus.

Seven pyrazole compounds were synthesized and characterized by ¹H NMR and MS, and the cytotoxicity of the compounds on Bel-7402, KB, HL-60, and BGC-823 was tested by MTT assay. The results showed that compound 4f exhibited higher cytotoxicity against Bel-7402 and BGC-823 cell lines.

Guangzhou Huagong published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C13H10O2, Name: 4-(1H-Pyrazol-4-yl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Xu, Shengjie published the artcileDesign, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents, Application In Synthesis of 19959-71-8, the publication is Medicinal Chemistry Research (2013), 22(11), 5610-5616, database is CAplus.

A novel series of N-arylpyrazole derivatives I(R = 4-CF₃, 3,5-(CF₃)₂, 4-NO₂), II, III and IV(R = H, OC₈H₁₇) has been designed and synthesized via aromatic substitution reaction of N-nonsubstituted pyrazoles with 4-fluoronitrobenzene in the presence of base. The structures of these compounds were established on the basis of elemental (C, H, and N) and spectral anal. (¹H NMR, ¹³C NMR, HRMS, and FT-IR). All the compounds were tested for their cytotoxic activity in vitro against four human tumor cell lines: carcinoma (Bel-7402), nasopharyngeal carcinoma (KB), immature granulocyte leukemia (HL-60), and gastrocarcinoma (BGC-823) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The results showed that most of the obtained compounds exhibited promising cytotoxicity against tested carcinoma cell lines with low IC₅₀ values. The bis-pyrazole derivative IV(R = OC₈H₁₇), bearing alkoxy group on the 5-position of Ph ring, was the most effective one. It is inhibition of cell growth of Bel-7402 cells was 1.5-fold higher than that found for cisplatin. And, also mono-pyrazole derivatives I(R = 4-CF₃, 3,5-(CF₃)₂) decorated with trifluoromethyl group on the Ph ring, displayed better cytotoxicity than that of cisplatin against Bel-7402 cell line.

Medicinal Chemistry Research published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C18H10F3NO3S2, Application In Synthesis of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Avinesh, P. published the artcileFacile Synthesis of Fully Decorated Imidazo[4,5-b] and Imidazo[4,5-c] Pyridines in Aqueous DMF via C-H Activation under Microwave Irradiation, HPLC of Formula: 1190875-39-8, the publication is ChemistrySelect (2016), 1(10), 2265-2270, database is CAplus.

Catalytic C-H bond activation of heteroarenes has gained tremendous potential in recent years due to their environmentally and economically benign nature. In this paper, the regioisomeric synthesis of fully decorated imidazopyridines, e.g., I employing a C-H activation protocol with a wide range of aryl/hetero aryl/alkyl boronic acids, e.g., II in aqueous DMF is reported. The use of inexpensive copper catalyst and bathophenanthroline as ligand were found to be instrumental in driving these reactions to completion. This optimized protocol was further extended to alkyl/aryl/heteroaryl potassium organo trifluoroborates such as potassium trifluoro(4-methoxyphenyl)boranuide, potassium trifluoro[4-(trifluoromethyl)phenyl]boranuide, potassium trifluoro(3,4,5-trimethylphenyl)boranuide, etc. A wide range of diversely substituted imidazo pyridine analogs which are known for their potential therapeutic applications have been synthesized using this highly efficient and atom economical protocol.

ChemistrySelect published new progress about 1190875-39-8. 1190875-39-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Piperidine,Boronic acid and ester,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid, and the molecular formula is C13H22BN3O4, HPLC of Formula: 1190875-39-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Srivastava, Manish Kumar published the artcileCoordination propensity of N-protected amino acids and sterically congested heterocyclic 尾-diketones toward BuSnCl₃: preparation and structural features of some new seven coordinated organic-inorganic hybrid formulations of monobutyltin(IV), COA of Formula: C17H14N2O2, the publication is Main Group Metal Chemistry (2014), 37(3-4), 75-83, database is CAplus.

Organotin carboxylate complexes I (1–4; 1, X = CH₂CH, R = H, R¹ = Ph; 2, X = CH₂CH, R = H, R¹ = Me; 3, X = CH, R = s-Bu, R¹ = Ph; 4, X = CH, R = s-Bu, R¹ = 4-ClC₆H₄) and II (5–8; 5, X = CH₂CH, R = H, R¹ = P h; 6, X = CH, R = s-Bu, R¹ = Ph; 7, X = CH, R = s-Bu, R¹ = 4-ClC₆H₄; 8, X = CH, R = s-Bu, R¹ = Me), derived from phthaloyl-protected amino acids, were prepared by the reactions of monobutyltin(IV) chloride with sodium salts of N-protected amino acids and sterically congested heterocyclic 尾-diketones in 1:1:1 and 1:2:1 molar ratios in refluxing dry THF and characterized by spectral methods. Plausible structures of these N-protected amino acids and sterically congested heterocyclic 尾-diketones-modified BuSnCl₃ formulations were suggested on the basis of physicochem. and spectral studies. These newly prepared organic-inorganic hybrid complexes of monobutyltin(IV) contain seven coordinated tin centers as revealed by ¹¹⁹Sn NMR spectral data.

Main Group Metal Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H8N2, COA of Formula: C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Sanjeev, R. published the artcileStudy on associative and non-associative behavior of some 5-membered heterocycles with two and one hetero atoms and their N-methylated derivatives from surface tension data, Recommanded Product: 1-Methylpyrazole, the publication is Research Journal of Chemistry and Environment (2015), 19(2), 26-29, database is CAplus.

Simple 5-membered heterocycles and two of their Nmethylated derivatives with two hetero atoms viz. pyrazole, isoxazole isothiozole and 1-methylpyrazole and with one hetero atom viz. pyrrole, furan, thiophene and N-methylpyrrole have shown a discriminative behavior toward surface tension, E脰TV脰S constants (k), order of association (x). This was explained in terms of associative and nonassociative behavior of these eight compounds Trouton’s rule had negligible significance on the associative and non-associative behavior.

Research Journal of Chemistry and Environment published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Recommanded Product: 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics