Day: October 13, 2022

The author of 《Analysis of bio-active compounds present in the leaves and stem of Trichosanthes roxb. using GC-MS technique with respect to its anti-inflammatory action》 were Aravindakshan, Aghil Soorya; Thangavel, Sekar. And the article was published in International Journal of Pharmacy and Pharmaceutical Sciences in 2021. Synthetic Route of C4H6N2 The author mentioned the following in the article:

Structural elucidation studies on Trichosanthes lobata Et acetate and methanol extracts of leaf and stem parts through Gas Chromatog.-Mass Spectrometry (GC-MS) technique with respect to anti-inflammatory potential. Extracts obtained with shade dried and powd. samples in successive solvent extraction using Et acetate and methanol by Soxhlet apparatus and subjected to GC-MS anal. and interpreted for its anti-inflammatory compounds The study revealed that the extraction solvent used was able to recover compound of classes such as organic acid esters and conjugated alkaloids in larger quantities than other classes of compounds and they varied with leaf and stem and also with the polarity of solvents used. In total compounds identified, GC-MS profile of the Et Acetate leaf extract of T. lobata contained 41 compounds, stem extract contained 45 compounds which have reported bioassays in PubChem. Whereas GC-MS profile of methanol leaf extract of T. lobata contained 66 compounds and stem extract contained 46 compounds having bioassay reports in PubChem. A large number of phytochem. peaks with good area percentage were found in methanolic extract We were also able to find out potent anti-inflammatory compounds including Octanoic acid, Dodecanoic acid, Octadecane, Enoic acid, Hexanoic acid, Quinazolin-8-one, Ilicic acid, Pentadecanoic acid, Oxaspiro, Benzeneacetic acid, etc. from the extracts T. lobata contains phytocompounds against inflammation which may serve as a new drug lead of natural products origin in future and make it employable in modern pharmacol. practices.1-Methylpyrazole(cas: 930-36-9Synthetic Route of C4H6N2) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Synthetic Route of C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Quantum-chemical study of the structure and reactivity of pyrazol-5-ones and their thio and seleno analogs. III. Semiempirical calculations of the structure and acid-base properties of 1-methyl-4H-pyrazol-5-one, -thione, and -selenone》 was written by Chmutova, G. A.; Kurbangalieva, A. R.; Kuznetsova, L. S.; Movchan, A. I.. Formula: C4H6N2O And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) on August 31 ,1997. The article conveys some information:

Tautomerism and acid-base properties of 1-methyl-4H-pyrazol-5-one and its thio and seleno analogs were studied by the semiempirical quantum-chem. methods MNDO, AM1, and PM3. The CH form prevails in pyrazolone, whereas the EH forms (E = S, Se) prevail in hetero analogs. The calculations predict an increase in the gas-phase acidity in the series O < S < Se. The gas-phase basicity of these compounds does not change in such a regular manner. After reading the article, we found that the author used 2-Methyl-1H-pyrazol-3(2H)-one(cas: 3310-35-8Formula: C4H6N2O)

2-Methyl-1H-pyrazol-3(2H)-one(cas: 3310-35-8) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C4H6N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 3310-35-8On May 31, 2001, Chmutova, G. A.; Kurbangalieva, A. R.; Vedernikov, A. N. published an article in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii). The article was 《Quantum-chemical studies of the structure and reactivity of pyrazol-5-ones and their thio and seleno analogs: V. Effect of electron correlation on tautomerism and acidity of 1-methylheteropyrazolones》. The article mentions the following:

The relative stability of tautomeric forms of 1-methyl-substituted heteropyrazolones (O, S, Se) and their gas-phase acidity were estimated by DFT calculations with various basis sets and methods of geometry optimization. The electron correlation effects make an appreciable contribution to the Gibbs free energies of their tautomers and anions, especially those containing the heavy atoms. The qual. pattern of tautomerism in pyrazolones is essentially similar to that obtained by semiempirical and nonempirical RHF calculations: the most stable is the CH form. For hetero analogs, consideration of electron correlations effects increases the relative stability of SH (SeH) forms. The series of relative acidity of the compounds depending on the heteroatom is preserved (Se ≥ S >> O). The experimental part of the paper was very detailed, including the reaction process of 2-Methyl-1H-pyrazol-3(2H)-one(cas: 3310-35-8Product Details of 3310-35-8)

2-Methyl-1H-pyrazol-3(2H)-one(cas: 3310-35-8) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 3310-35-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1990,Randow, Hendrik; Miethchen, Ralf published 《Regioselectivity in N-alkylations of pyrazoles and 1,2,4-triazoles》.Wissenschaftliche Zeitschrift der Universitaet Rostock, Naturwissenschaftliche Reihe published the findings.Product Details of 15366-34-4 The information in the text is summarized as follows:

The regioselectivity of the N-alkylation of pyrazoles I (R1 = H, Me, Br, Cl, iodo; R2 = H, Br, iodo; R3 = Me, CO2Me, Br, iodo) and the triazoles II (R4 = Br, Cl) with BrCH2COOMe and, in some cases, MeI is discussed with the help of product NMR data. The experimental process involved the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Product Details of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Product Details of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Krishnan, R.; Seshadri, S. published an article in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The title of the article was 《Synthesis of aryltriazolyl derivatives》.COA of Formula: C9H7N3O2 The author mentioned the following in the article:

Amino azo compounds I (R1 = H, Ph) were treated with Cu(OAc)2 in DMF to give naphthotriazoles II. I were prepared from the resp. 4-(4-pyrazolyl)anilines and 2-amino-1-naphthalenesulfonic acid. In the experiment, the researchers used many compounds, for example, 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9COA of Formula: C9H7N3O2)

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. COA of Formula: C9H7N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1-Butyl-1H-pyrazoleOn October 31, 1999 ,《Structural regularities governing sorption and gas chromatographic retention of aromatic nitrogen-containing heterocyclic compounds》 appeared in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya). The author of the article were Zhuravleva, I. L.; Kuz’menko, T. E.. The article conveys some information:

The regularities governing differences in the gas-chromatog. retention indexes of aromatic N-containing heterocyclic compounds were studied during gas-chromatog. anal. on a nonpolar capillary column. The retention indexes of pyrrole, pyrazole, imidazole, 1,2,4-triazole, oxazole, thiazole, isoxazole, pyridine, pyridazine, pyrimidine, pyrazine, and s-triazine and their alkyl derivatives depend on the number, nature, and arrangement of heteroatoms and alkyl groups in the cycles. The majority of homologous series of n-alkyl-substituted azoles and azines and n-alkylbenzenes is characterized by anomalously high differences between the retention indexes of Et and Me homologs. A scheme of calculating retention indexes of aromatic heterocyclic compounds from increments of heteroatoms was proposed. In the part of experimental materials, we found many familiar compounds, such as 1-Butyl-1H-pyrazole(cas: 52096-24-9Application In Synthesis of 1-Butyl-1H-pyrazole)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application In Synthesis of 1-Butyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics