Month: October 2022

Product Details of 52096-24-9On March 17, 2017, Kim, Og Soon; Jang, Jin Hyeok; Kim, Hyun Tae; Han, Su Jin; Tsui, Gavin Chit; Joo, Jung Min published an article in Organic Letters. The article was 《Synthesis of Fluorescent Indazoles by Palladium-Catalyzed Benzannulation of Pyrazoles with Alkynes》. The article mentions the following:

Pentasubstituted indazoles such as I (R = H, Me, t-Bu, MeO, EtO2C, F, Cl) were prepared in 34-84% yields by oxidative benzannulation reactions of pyrazoles such as 1-methylpyrazole with sym. internal alkynes such as 4-(4-RC6H4CC)C6H4R (R = H, Me, t-Bu, MeO, EtO2C, F, Cl) in the presence of Pd(OAc)2 and Cu(OAc)2 in 1,4-dioxane or by benzannulation of substituted 4-bromopyrazoles with sym. internal alkynes in the presence of Pd(OAc)2, t-Bu3P•HBF4, K2CO3, and pivalic acid in toluene; unsym. internal alkynes gave mixtures of regioisomers. 1,2-Disubstituted imidazoles also underwent oxidative benzannulation with diphenylacetylene in the presence of Pd(OAc)2 and Cu(OAc)2 in 1,4-dioxane to yield tetraphenylbenzimidazoles in 41-50% yields. The fluorescence and optical bandgaps of I (R = H, t-Bu, MeO, EtO2C, F, Cl) were determined The structure of I (R = H) was determined by X-ray crystallog. In the part of experimental materials, we found many familiar compounds, such as 1-Butyl-1H-pyrazole(cas: 52096-24-9Product Details of 52096-24-9)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 52096-24-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Safety of Methyl 1-methyl-1H-pyrazole-4-carboxylateOn October 6, 2017 ,《The Direct C-H Difluoromethylation of Heteroarenes Based on the Photolysis of Hypervalent Iodine(III) Reagents That Contain Difluoroacetoxy Ligands》 was published in Organic Letters. The article was written by Sakamoto, Ryu; Kashiwagi, Hirotaka; Maruoka, Keiji. The article contains the following contents:

In this letter, an efficient method for the photolytic generation of difluoromethyl radicals from [bis(difluoroacetoxy)iodo]benzene reagents is described. The present approach enables the introduction of difluoromethyl groups into various heteroarenes under mild conditions in the absence of any addnl. reagents or catalysts. The experimental process involved the reaction of Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2Safety of Methyl 1-methyl-1H-pyrazole-4-carboxylate)

Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Safety of Methyl 1-methyl-1H-pyrazole-4-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 930-36-9On May 3, 2021 ,《Electrophotocatalytic C-H Azolation of Arenes》 appeared in ChemElectroChem. The author of the article were Hou, Zhong-Wei; Xu, Hai-Chao. The article conveys some information:

An electrophotocatalytic method was developed for the dehydrogenative cross coupling of arenes with azoles employing a bicatalytic system consisting of acridinium dye and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). The reactions were conducted in a simple undivided cell with visible-light irradiation and requires no external chem. oxidant. In addition to this study using 1-Methylpyrazole, there are many other studies that have used 1-Methylpyrazole(cas: 930-36-9Product Details of 930-36-9) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2011,Guillou, Sandrine; Bonhomme, Frederic J.; Ermolenko, Mikhail S.; Janin, Yves L. published 《Simple preparations of 4 and 5-iodinated pyrazoles as useful building blocks》.Tetrahedron published the findings.Computed Properties of C4H3F3N2 The information in the text is summarized as follows:

The pyrazole nucleus has recently become a recurrent scaffold in the research fields of CropScience and oncol. We report here the preparation of an array of 4- and 5-iodinated pyrazole derivatives, such as 4-iodo-3-trifluoromethylpyrazole or Et 5-iodo-4-carboxy-3-trifluoromethylpyrazoles. This work provide access to many new pyrazole derivative, including eleven original out of sixteen iodinated building blocks, thus opening accesses to new chem. entities featuring a pyrazole nucleus.3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Computed Properties of C4H3F3N2) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2012,Rampazzi, Vincent; Massard, Alexandre; Richard, Philippe; Picquet, Michel; Le Gendre, Pierre; Hierso, Jean-Cyrille published 《A simple phosphine-diolefin-promoted copper-catalyzed N-arylation of pyrazoles with (hetero)aromatic bromides: the case of chloroarenes revisited》.ChemCatChem published the findings.Related Products of 20154-03-4 The information in the text is summarized as follows:

A molecularly defined new phosphine-diolefin cubane copper pre-catalyst used at 1.25 mol % under mild conditions promotes the coupling of pyrazoles to functionalized aryl and heteroaryl bromides, which hold a variety of functional groups. This versatile phosphorus-based system was thus successfully used, under identical conditions, for the coupling of a large scope of heteroaromatics to selectively produce pyridinyl- and pyrimidinyl-pyrazoles, as well as several novel furyl-, thienyl- and thiazolyl-substituted pyrazoles. The careful investigation of coupling with the analogous aryl and heteroaryl chlorides clearly indicated that for specifically activated chloroarenes a direct nucleophilic aromatic substitution (SNAr) is easily achieved in the absence of any copper and ligand. These results are pertinent with regards to the reported protocols in which copper-ligand systems have been claimed as useful for coupling activated chloroarenes. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Related Products of 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Related Products of 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 20154-03-4In 2010 ,《Lewis Acid Catalyzed Synthesis of Poly(pyrazolyl)borate Ligands》 appeared in Organometallics. The author of the article were Chen, Changle; Jordan, Richard F.. The article conveys some information:

Lewis acids catalyze the reaction of Li[MeBH3] and Na[BH4] with pyrazoles to yield poly(pyrazolyl)borates under mild conditions. The reaction of Li[MeBH3] with 2 equiv of 3-mesitylpyrazole (HpzMs) at 23° (2 days) affords Li[MeB(3-mesityl-pz)2H] (Li[MeBpMs]) and Li[MeB(3-mesityl-pz)(5-mesityl-pz)H] (Li[MeBpMs*]) in 88% yield (3:1 isomer ratio) in the presence of MeB(OiPr)2 (5 mol % vs. HpzMs) but only 28% yield without this additive. Similar enhancements in the yield of Li[MeBpR] products are observed in the reaction of Li[MeBH3] with 3-tBu-pyrazole, 3,5-Me2-pyrazole (Hpz*), and 3,5-tBu2-pyrazole. The kinetics of the MeB(OiPr)2-catalyzed and uncatalyzed reaction of Li[MeB(3-mesityl-pz)H2]/Li[MeB(5-mesityl-pz)H2] with HpzMs were compared assuming that Li[MeB(3-mesityl-pz)H2] and Li[MeB(5-mesityl-pz)H2] react at the same rate. The estimated second-order rate constants are k(catalyzed) = 1.0 × 10-4 M-1 s-1 and k(uncatalyzed) = 2.1 × 10-5 M-1 s-1 at 23° in THF. The reaction of Li[MeBH3] with 3 equiv of HpzMs (THF, 60°, 2 days) in the presence of 3 mol % MeB(OiPr)2 affords Li[MeB(3-mesityl-pz)3] (75% yield), but only Li[MeBpMs] and Li[MeBpMs*] without this additive. Similar results were observed for the reaction of Li[MeBH3] with 3-CF3-pyrazole. The reaction of Na[BH4] and 3 equiv of Hpz* (THF, 60°, 4 h) gave Na[B(3,5-Me2-pz)2H2] in 93% yield in the presence of BF3·Et2O (5 mol % vs. Hpz*) but only 5% without this additive. Coordination of the pyrazole to the Lewis acid is expected to decrease the pKa of the pyrazole and increase the rate of B-H bond protonolysis. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4HPLC of Formula: 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.HPLC of Formula: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Palladium-catalyzed polyannulation of pyrazoles and diynes toward multifunctional poly(indazole)s under monomer non-stoichiometric conditions》 was published in Polymer Chemistry in 2019. These research results belong to Gao, Qingqing; Han, Ting; Qiu, Zijie; Zhang, Ruoyao; Zhang, Jun; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Tang, Ben Zhong. Category: pyrazoles-derivatives The article mentions the following:

A new synthetic route toward multifunctional poly(indazole)s (PIs) with an effect of monomer stoichiometry imbalance-promoted polymerization is described in this work. The palladium-catalyzed oxidative polyannulations of internal diynes and 1-methylpyrazole proceed smoothly in 1,4-dioxane at 120°C with copper acetate monohydrate functioning as the oxidant. A series of PIs with high mol. weights (Mw up to 35 800) are generated in good yields (up to 84.0%) under monomer non-stoichiometric conditions. These polymers exhibit high thermal stability, losing merely 5% of their weights at high temperatures of 321-353°C. The solid thin films of these PIs show high and UV-tunable refractive indexes (n = 1.8870-1.6051) in a wide wavelength range of 400-900 nm. The tetraphenylethene-containing PI shows obvious solid-state emission properties and good photosensitivity. Its thin film was successfully fabricated into a well-defined two-dimensional fluorescent photopattern with sharp edges. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 930-36-9On May 31, 2019, Doba, Takahiro; Matsubara, Tatsuaki; Ilies, Laurean; Shang, Rui; Nakamura, Eiichi published an article in Nature Catalysis. The article was 《Homocoupling-free iron-catalyzed twofold C-H activation/cross-couplings of aromatics via transient connection of reactants》. The article mentions the following:

Herein, an efficient strategy was developed for the synthesis of biaryls and (aryl)alkenamides Ar(R)C=C(R1)C(O)NHAr1 [R = Me; R1 = Me; RR1 = (CH2)4; Ar = 3,4-Cl2C6H3, 5-Ph-2-thienyl, benzothiophen-2-yl, etc.; Ar1 = 8-quinolyl] via iron-catalyzed twofold C-H activation/cross-coupling of arenes with alkenyl/aryl carboxamides. A transient connection of two reactants by an anionic group appended to one reactant helped to achieve this goal under mildly oxidative iron-catalyzed conditions, through the formation of a productive heteroleptic R1-M-R2 intermediate. An N-(quinolin-8-yl)amide anion was utilized for the temporary connection and cross-coupled a stoichiometric mixture of aromatics in high yield without any trace of homocoupling products. A short-step synthesis of several donor/acceptor thiophene compounds and carbon/sulfur-bridged flat conjugated systems illustrated the utility of this method to streamline organic synthesis. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Application of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates》 were Meador, Rowan I. L.; Mate, Nilamber A.; Chisholm, John D.. And the article was published in Organics in 2022. Safety of 4-(4-Nitrophenyl)-1H-pyrazole The author mentioned the following in the article:

A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles C(Cl)3C=(NH)OR1 (R1 = 1-phenylethyl, 1-(naphthalen-2-yl)ethyl, benzyl, 2H-1,3-benzodioxol-5-yl(phenyl)methyl, etc.) and a Bronsted acid catalyst. These reactions provide ready access to N-alkyl pyrazoles, e.g., I, which are present in a variety of medicinally relevant lead structures. Benzylic, phenethyl and benzhydryl trichloroacetimidates provide good yields of the N-alkyl pyrazole products. Unsym. pyrazoles provide a mixture of the two possible regioisomers, with the major product being controlled by sterics. This methodol. provides an alternative to other alkylation methods that require strong base or high temperature In addition to this study using 4-(4-Nitrophenyl)-1H-pyrazole, there are many other studies that have used 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Safety of 4-(4-Nitrophenyl)-1H-pyrazole) was used in this study.

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Safety of 4-(4-Nitrophenyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2014,Sharp, Phillip P.; Garnier, Jean-Marc; Huang, David C. S.; Burns, Christopher J. published 《Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition》.MedChemComm published the findings.Related Products of 847818-74-0 The information in the text is summarized as follows:

The ability of various functional groups to engage the acetyl-lysine (KAc) binding site within bromo- and extra-terminal domain (BET) protein family members BRD2, BRD3 and BRD4 was evaluated by screening small mol. fragments – coupled to a known arylsulfonamide scaffold – in biochem. inhibition assays. Useful structure activity relationships have been established and novel functional groups that bind to the KAc binding pocket identified. Addnl. microsomal degradation studies were also undertaken revealing significant differences in metabolic stability between two commonly employed BET inhibitor fragments. In addition to this study using 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, there are many other studies that have used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Related Products of 847818-74-0) was used in this study.

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Related Products of 847818-74-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics