Day: October 25, 2021

Computed Properties of C12H12N2O3. Authors Milne, IA; Graham, JMR in CAMBRIDGE UNIV PRESS published article about in [Milne, I. A.] Univ Western Australia, Oceans Grad Sch, Crawley 6009, Australia; [Graham, J. M. R.] Imperial Coll London, Dept Aeronaut, London SW7 2AZ, England in 2019, Cited 13. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

The changes in spectra and intensities of the streamwise component of turbulent velocity are calculated in the inflow of a turbine rotor. The flow is initially calculated in the limit when the turbulence is of small scale compared with the rotor diameter. Rapid distortion theory (RDT), Batchelor & Proudman (Q. J. Mech. Appl. Maths, vol. 7 (1), 1954, pp. 83-103) (BP), for small-scale turbulence is combined with the effect of the fluctuating potential flow field on the turbulence caused by the direct interaction of the incident turbulence with the rotor as a sheet of resistance. A second computation is then carried out for turbulence of larger length scale. The results of the calculations are compared with velocity measurements in the inflow of both a commercial wind turbine and a tidal turbine rotor.

About 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, If you have any questions, you can contact Milne, IA; Graham, JMR or concate me.. Computed Properties of C12H12N2O3

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

COA of Formula: C5H8N2. Ohmatsu, K; Nakashima, T; Sato, M; Ooi, T in [Ohmatsu, Kohsuke; Nakashima, Tsubasa; Sato, Makoto; Ooi, Takashi] Nagoya Univ, Grad Sch Engn, Inst Transformat Biomol WPI ITbM, Nagoya, Aichi 4648601, Japan; [Ohmatsu, Kohsuke; Nakashima, Tsubasa; Sato, Makoto; Ooi, Takashi] Nagoya Univ, Grad Sch Engn, Dept Mol & Macromol Chem, Nagoya, Aichi 4648601, Japan; [Ooi, Takashi] Japan Sci & Technol Agcy JST, CREST, Nagoya, Aichi 4648601, Japan published Direct allylic C-H alkylation of enol silyl ethers enabled by photoredox-Bronsted base hybrid catalysis in 2019.0, Cited 36.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Strategies for altering the reaction pathway of reactive intermediates are of significant importance in diversifying organic synthesis. Enol silyl ethers, versatile enolate equivalents, are known to undergo one-electron oxidation to generate the radical cations that spontaneously form electrophilic alpha-carbonyl radicals via elimination of the silyl groups. Here, we demonstrate that close scrutiny of the property of the radical cations as strong C-H acids enables the identification of a catalyst system consisting of an iridium-based photosensitizer and 2,4,6-collidine for the generation of nucleophilic allylic radicals from enol silyl ethers through one-electron oxidation-deprotonation sequence under light irradiation without the desilylation of the radical cation intermediates. The resultant allylic radicals engage in the addition to electron-deficient olefins, establishing the selective allylic C-H alkylation of enol silyl ethers. This strategy is broadly applicable, and the alkylated enol silyl ethers can be transformed into highly functionalized carbonyl compounds by exploiting their common polar reactivity.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Ohmatsu, K; Nakashima, T; Sato, M; Ooi, T or concate me.. COA of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

COA of Formula: C5H8N2. Authors Amoah, C; Obuah, C; Ainooson, MK; Muller, A in ELSEVIER SCIENCE SA published article about in [Amoah, Cephas; Obuah, Collins; Ainooson, Michael Kojo] Univ Ghana, Dept Chem, Legon, Ghana; [Obuah, Collins; Ainooson, Michael Kojo; Muller, Alfred] Univ Johannesburg, Dept Chem Sci, Auckland Pk Kingsway Campus, ZA-2006 Johannesburg, South Africa in 2021.0, Cited 31.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

The search for new fluorescent materials with high quantum yields has been the focus of research, considering the diverse applications that fluorescent materials present. In this study, ferrocenyl pyrazolyl (L1) and ferrocenyl triazolyl (L2) ligands and their palladium metal complexes (1 and 2) were synthesized to investigate their fluorescence properties. While the pyrazolyl ligand was prepared through a ligand substitution reaction, synthesis of the triazolyl derivative involved the [3 + 2] azide-alkyne using click chemistry. All the prepared compounds have been characterized by NMR and IR spectroscopy, elemental analysis, mass spectrometry and single-crystal X-ray crystallography. These air-stable compounds were prepared in moderate to good yields (70% and 83%). The ferrocenyl-pyrazolyl L1 and ferrocenyl-triazolyl L2 ligands showed near-infrared (NIR) emission bands with quantum yields of 20% and 26% respectively. The addition of the Pd2+ ions results in the reduction of fluorescence intensity and quantum yield. Such fluorescent properties demonstrate their potential use in bio-analysis and as fluorogenic probing. (C) 2020 Elsevier B.V. All rights reserved.

COA of Formula: C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Amoah, C; Obuah, C; Ainooson, MK; Muller, A or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In 2021 CHEM-EUR J published article about ENANTIOSELECTIVE ADDITION; TERTIARY ALCOHOLS; PYRAZOLONE DERIVATIVES; ORGANOZINC REAGENTS; ALKYLZINC REAGENTS; ALPHA-KETOESTERS; KETONES; DIETHYLZINC; HYDROXYLATION; DIMETHYLZINC in [Wang, Rong-Hui; Li, Ya-Ling; He, Hong-Jiao; Xiao, You-Cai; Chen, Fen-Er] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China; [Chen, Fen-Er] Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, Shanghai 200433, Peoples R China; [Chen, Fen-Er] Shanghai Engn Ctr Ind Asymmetr Catalysis Chiral D, Shanghai 200433, Peoples R China in 2021, Cited 67. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0. HPLC of Formula: C11H12N2O

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.

HPLC of Formula: C11H12N2O. About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Wang, RH; Li, YL; He, HJ; Xiao, YC; Chen, FE or concate me.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Csany, G; Szalai, K; Gyongy, M in [Csany, Gergely; Gyongy, Miklos] Pazmany Peter Catholic Univ, Fac Informat Technol & Bion, Budapest, Hungary; [Szalai, Klara] Semmelweis Univ, Dept Dermatol Venerol & Dermatooncol, Budapest, Hungary published A real-time data-based scan conversion method for single element ultrasound transducers in 2019, Cited 42. SDS of cas: 83-10-3. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3.

The current work investigates the performance of a real-time scan conversion algorithm for generating a 2-D ultrasound image from a laterally scanned single-element ultrasound transducer, which has applications in point-of-care devices such as for skin imaging. The algorithm employs a fixed calibration curve to update a predefined image grid in real time. Simulations showed that the calibration curve (with a maximum of 1) is robust to changes in scatterer concentration (8.3 x 10(-3) mean absolute error), signal to noise ratio (1.0 x 10(-3) mean absolute error for -5 dB SNR), and can be accurately predicted from a small number (31) of point scatterers (6.9 x 10(-3) mean absolute error). Good agreement was also found between the calibration curves obtained from simulated and experimental data (1.19 x 10(-2) mean absolute error). The scan conversion algorithm was validated by evaluation of the position estimation errors on both simulations and experiments. Clinical images of skin lesions (N = 20) demonstrate the feasibility of the algorithm for real, non-homogeneous tissue. Use of a fixed calibration curve compared to an adaptive calibration curve gave similar accuracies in the scanning step size range of 150-350 mu m (with an average overlap of the accuracy ranges of 92.94% for simulations and 42.83% for experiments), and a 350-fold improvement in computation time.

SDS of cas: 83-10-3. About 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, If you have any questions, you can contact Csany, G; Szalai, K; Gyongy, M or concate me.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C11H12N2O. In 2019 ANGEW CHEM INT EDIT published article about ASYMMETRIC-SYNTHESIS; SPIROPYRAZOLONES; ISOXAZOLINONES; DENDRALENES; ANNULATION; GENERATION; REACTIVITY; YLIDES in [Li, Long; Luo, Pengfei; Deng, Yuhua; Shao, Zhihui] Yunnan Univ, Key Lab Med Chem Nat Resource, State Key Lab Conservat & Utilizat Bioresources Y, Minist Educ,Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China in 2019, Cited 65. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0.

The first Pd-catalyzed asymmetric allenylic [4+1] cycloaddition was successfully developed. Alternatively, tuning the Pd catalyst switched the reactivity toward an unprecedented [4+3] cycloaddition/cross-coupling. Ligands play a vital role in controlling the reaction pathway, allowing highly selective access to different products from identical substrates. Biological evaluation of the obtained compounds led to the discovery of new antitumor targets. A possible mechanism is proposed, suggesting two interesting catalytic cycles for the cycloaddition with palladium-butadienyls. This study also demonstrated the potential and utility of allenic esters as 1,4-biselectrophiles and C-4 synthons for participating in cycloaddition reactions.

Formula: C11H12N2O. About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Li, L; Luo, PF; Deng, YH; Shao, ZH or concate me.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

SDS of cas: 86-92-0. Recently I am researching about HENRY NITROALDOL REACTIONS; ORGANIC-SYNTHESIS; ON-WATER; DERIVATIVES; ANTIPYRINE; ALCOHOLS; HETEROCYCLES; CHEMISTRY; CYCLIZATION; EFFICIENT, Saw an article supported by the Jiangxi Provincial Department of Science and Technology Fund [20192BAB213007]; Education Department of Jiangxi Province [G11170835]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21865003, 21763002]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Zhang, Y; Nie, LJ; Luo, L; Mao, JX; Liu, JX; Xu, GH; Chen, DL; Luo, HQ. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone

The selective condensation of pyrazolones with isatins using water as the reaction medium is presented. This strategy provides an environmentally benign synthetic route to synthesize various potentially bioactive pyrazolone substituted oxindoles. (C) 2020 Elsevier Ltd. All rights reserved.

SDS of cas: 86-92-0. About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Zhang, Y; Nie, LJ; Luo, L; Mao, JX; Liu, JX; Xu, GH; Chen, DL; Luo, HQ or concate me.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article Polycyclic N-oxides: high performing, low sensitivity energetic materials WOS:000459474300009 published article about FUSED HETEROCYCLE; CRYSTAL PACKING; CHEMISTRY; TETRAZINE; REDOX in [Snyder, Christopher J.; Wells, Lucille A.; Chavez, David E.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA; [Imler, Gregory H.; Parrish, Damon A.] US Navy, Res Lab, Washington, DC 20375 USA in 2019.0, Cited 46.0. SDS of cas: 67-51-6. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Polycyclic N-oxides were developed based on the heterocycles 1,2,4,5-tetrazine and 4H, 8H-difurazano[3,4-b:3′,4′-e]pyrazine. The new compounds are energetic and have excellent explosive properties, while maintaining low mechanical sensitivities. Most notably, compound 7 is thermally stable, insensitive, and has superior detonation properties to the state-of-the-art insensitive high explosive, 1,3,5-triamino-2,4,6-trinitrobenzene.

SDS of cas: 67-51-6. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Snyder, CJ; Wells, LA; Chavez, DE; Imler, GH; Parrish, DA or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis, biological evaluation, structure-activity relationship, and toxicity of clinafloxacin-azole conjugates as novel antitubercular agents published in 2019.0. Computed Properties of C5H8N2, Reprint Addresses Yang, DC (corresponding author), Southwest Univ, Sch Chem & Chem Engn, Inst Bioorgan & Med Chem, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China.; Tang, XM (corresponding author), Southwest Univ, Sch Life Sci, Chongqing 400715, Peoples R China.. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

Based on the advantages of azole molecules and fluoroquinolone drugs, we designed and synthesized 34 clinafloxacin- azole conjugates using fragment-based drug design and drug combination principles. The in vitro activities of the synthesized conjugates against Mycobacterium tuberculosis (H37Rv), Hela cell as well as Gram-positive and Gram-negative bacteria were assayed. The bioassay results revealed that most of the target molecules had anti-tuberculosis (anti-TB) activity, of which 14 compounds had very strong anti-TB activity [minimum inhibitory concentration (MIC) < 2 mu M]. In addition, the compounds with strong activity towards H37Rv had weak activity towards Gram-negative and Gram-positive bacteria, showing obvious selectivity towards H37Rv. Predicted toxicity data indicated that 27 molecules were less toxic or equivalent to that of the original drug (clinafloxacin). Especially, it is demonstrated that compound TM2l exhibited the strongest anti-TB activity (MIC = 0.29 mu M), low antibacterial activity, negligible toxicity, and good drug-likeness values, which can be considered as an ideal lead molecule for future optimization. Computed Properties of C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Liu, J; Ren, ZH; Fan, L; Wei, JY; Tang, XM; Xu, XR; Yang, DC or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article R(4)NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and Beyond WOS:000606840200025 published article about REGIOSELECTIVE IODINATION; NITROSYLSULFURIC ACID; AROMATIC-COMPOUNDS; EFFICIENT METHOD; NITROGEN-OXIDE; C-13 NMR; MILD; CONVENIENT; BROMINATION; 3,5-DIARYLISOXAZOLES in [Bondarenko, Oksana B.; Karetnikov, Georgy L.; Komarov, Arseniy, I; Pavlov, Aleksandr, I; Nikolaeva, Svetlana N.] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia in 2021.0, Cited 58.0. Quality Control of 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

A new convenient and versatile halogenating system (R(4)NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Bondarenko, OB; Karetnikov, GL; Komarov, AI; Pavlov, AI; Nikolaeva, SN or concate me.. Quality Control of 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics