Day: October 19, 2021

In 2019 J ORG CHEM published article about C-H ACTIVATION; SUBSTITUTED CINNOLINES; RING-SYSTEMS; CYCLIZATION; INHIBITORS; DERIVATIVES; DISCOVERY; ANTITUMOR; ANALOGS; ACCESS in [Liu, Chen-Fei; Liu, Man; Dong, Lin] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Sichuan, Peoples R China in 2019, Cited 55. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0. Quality Control of 3-Methyl-1-p-tolyl-5-pyrazolone

A highly efficient iridium-catalyzed cascade annulation of pyrazolones and sulfoxonium ylides to access various pyrazolo[1,2-alpha]cinnoline derivatives has been achieved. This novel approach expanded the application scope of coupling partners to ylides. The control experiments were performed to give insight into the mechanism of this reaction.

About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Liu, CF; Liu, M; Dong, L or concate me.. Quality Control of 3-Methyl-1-p-tolyl-5-pyrazolone

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Regioselectivity Switch in Palladium-Catalyzed Allenylic Cycloadditions of Allenic Esters: [4+1] or [4+3] Cycloaddition/Cross-Coupling published in 2019. Formula: C11H12N2O, Reprint Addresses Shao, ZH (corresponding author), Yunnan Univ, Key Lab Med Chem Nat Resource, State Key Lab Conservat & Utilizat Bioresources Y, Minist Educ,Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China.. The CAS is 86-92-0. Through research, I have a further understanding and discovery of 3-Methyl-1-p-tolyl-5-pyrazolone

The first Pd-catalyzed asymmetric allenylic [4+1] cycloaddition was successfully developed. Alternatively, tuning the Pd catalyst switched the reactivity toward an unprecedented [4+3] cycloaddition/cross-coupling. Ligands play a vital role in controlling the reaction pathway, allowing highly selective access to different products from identical substrates. Biological evaluation of the obtained compounds led to the discovery of new antitumor targets. A possible mechanism is proposed, suggesting two interesting catalytic cycles for the cycloaddition with palladium-butadienyls. This study also demonstrated the potential and utility of allenic esters as 1,4-biselectrophiles and C-4 synthons for participating in cycloaddition reactions.

About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Li, L; Luo, PF; Deng, YH; Shao, ZH or concate me.. Formula: C11H12N2O

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Authors Wu, GX; Xu, HH; Liu, ZR; Liu, YH; Yang, X; Zhang, XL; Huang, Y in AMER CHEMICAL SOC published article about ALLYLIC DEAROMATIZATION REACTION; STEREOCONTROLLED CONSTRUCTION; MICHAEL ADDITION; ALKYLATION; ACID; PYRAZOLIN-5-ONES; PYRAZOL-5-ONES; ALCOHOLS; BEARING in [Wu, Gengxin; Xu, Haohan; Liu, Ziran; Liu, Yonghong; Yang, Xiang; Huang, Yan] Xinjiang Univ, Coll Chem & Chem Engn, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uyghur Autonomous Reg, Urumqi 830000, Xinjiang, Peoples R China; [Zhang, Xulong] Xinjiang Uygur Autonomous Reg Prod Qual Supervis, Urumqi 830000, Xinjiang, Peoples R China in 2019, Cited 46. Formula: C11H12N2O. The Name is 3-Methyl-1-p-tolyl-5-pyrazolone. Through research, I have a further understanding and discovery of 86-92-0

In this letter, an efficient one-pot asymmetric sequential reaction is achieved by organo/transition metal relay catalysis in constructing two consecutive C-C bonds, which involves enantioselective amino squaramide catalytic Mannich-type addition of pyrazolones to isatin-derived ketimines and a subsequent palladium catalyzed diastereoselective allylic alkylation of pyrazolones with allylic acetates. An array of novel pyrazolone-aminooxindole-propylene structural motifs are obtained in a high level of yield and with excellent enantio- and diastereoselectivity (up to 95% yield, >20:1 dr, >99% ee). This methodology features the formation of vicinal quarternary carbon-stereocenters, and the second all-carbon tetrasubstituted stereogenic center is induced by joint action of the achiral palladium catalysis and the chiral environment generated from the Mannich step. Moreover, the usefulness of this methodology is highlighted by converting the allylic product into the carbonyl compound.

Formula: C11H12N2O. About 3-Methyl-1-p-tolyl-5-pyrazolone, If you have any questions, you can contact Wu, GX; Xu, HH; Liu, ZR; Liu, YH; Yang, X; Zhang, XL; Huang, Y or concate me.

Reference:
Article; Zhang, Yong; Nie, Long-Jun; Luo, Liang; Mao, Jia-Xin; Liu, Jin-Xiang; Xu, Guo-Hai; Chen, Deliang; Luo, Hai-Qing; Tetrahedron; vol. 76; 7; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article Luminescent Rhenium(I)tricarbonyl Complexes Containing Different Pyrazoles and Their Successive Deprotonation Products: CO2 Reduction Electrocatalysts WOS:000558727500078 published article about DENSITY-FUNCTIONAL THEORY; RHENIUM(I) TRICARBONYL COMPLEXES; TRANSITION-METAL-COMPLEXES; EFFECTIVE CORE POTENTIALS; PROTON RESPONSIVE LIGAND; ACID-BASE PROPERTIES; EXCITED-STATE; RE(I) COMPLEXES; CHARGE-TRANSFER; CARBON-DIOXIDE in [Merillas, Beatriz; Cuellar, Elena; Martin-Alvarez, Jose M.; Miguel, Daniel; Villafane, Fernando] Univ Valladolid, Fac Ciencias, GIR MIOMeT IU Cinquima Quim Inorgan, Campus Miguel Delibes, Valladolid 47011, Spain; [Diez-Varga, Alberto; Torroba, Tomas; Garcia-Herbosa, Gabriel] Univ Burgos, Fac Ciencias, Dept Quim, Burgos 09001, Spain; [Fernandez, Sergio; Lloret-Fillol, Julio] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain; [Lloret-Fillol, Julio] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain in 2020.0, Cited 100.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Recommanded Product: 3,5-Dimethyl-1H-pyrazole

Cationic fac-[Re(CO)(3)(pz*H)(pypzH)]OTf (pz*H = pyrazole, pzH; 3,5-dimethylpyrazole, dmpzH; indazole, indzH; 3-(2-pyridyl)pyrazole, pypzH) were obtained from fac[ReBr(CO)(3)(pypzH)] by halide abstraction with AgOTf and subsequent addition of the corresponding pyrazole. Successive deprotonation with Na2CO3 and NaOH gave neutral fac[Re(CO)(3)(pz*H)(pypz)] and anionic Na{fac-[Re(CO)(3)(pz*)(pypz)]} complexes, respectively. Cationic fac-[Re(CO)(3)(pz*H)(pypzH)]OTf, neutral complexes fac-[Re(CO)(3)(pz*H)(pypz)], and fac-[Re(CO)(3)(pypz)(2)Na] were subjected to photophysical and electrochemical studies. They exhibit phosphorescent decays from a prevalently (MLCT)-M-3 excited state with quantum yields (F) in the range between 0.03 and 0.58 and long lifetimes (tau from 220 to 869 ns). The electrochemical behavior in Ar atmosphere of cationic and neutral complexes indicates that the oxidation processes assigned to Re-I -> Re-II occurs at lower potentials for the neutral complex compared to cationic complex. The reduction processes occur at the ligands and do not depend on the charge of the complexes. The electrochemical behavior in CO2 saturated media is consistent with CO2 electrocatalyzed reduction, where the values of the catalytic activity [i(cat)(CO2)/i(cat)(Ar)] ranged from 2.7 to 11.5 (compared to 8.1 for fac-[Re(CO)(3)Cl(bipy)] studied as a reference). Controlled potential electrolysis for the pyrazole cationic (3a) and neutral (4a) complexes after 1 h affords CO in faraday yields of 61 and 89%, respectively. These values are higher for indazole complexes and may be related to the acidity of the coordinated pyrazole.

Recommanded Product: 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Merillas, B; Cuellar, E; Diez-Varga, A; Torroba, T; Garcia-Herbosa, G; Fernandez, S; Lloret-Fillol, J; Martin-Alvarez, JM; Miguel, D; Villafane, F or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Authors He, SR; Cao, CC; Wang, JL; Yang, JZ; Cheng, ZJ; Yan, BB; Pan, Y; Chen, GY in ELSEVIER published article about DAIRY MANURE; PY-GC/MS; TG-FTIR; COMBUSTION; CONVERSION; BIOOIL; TEMPERATURE; MECHANISM; KINETICS; LIGNIN in [He, Sirong; Cao, Congcong; Wang, Jinglan; Cheng, Zhanjun; Yan, Beibei] Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China; [Yang, Jiuzhong; Pan, Yang] Univ Sci & Technol China, Natl Synchrotron Radiat Lab, Hefei 230029, Anhui, Peoples R China; [Cheng, Zhanjun; Yan, Beibei] Tianjin Univ, Tianjin Engn Res Ctr Organ Wastes Safe Disposal &, Tianjin Key Lab Biomass Waste Utilizat, Key Lab Efficient Utilizat Low & Medium Energy, Tianjin 300072, Peoples R China; [Chen, Guanyi] Tianjin Univ Commerce, Sch Mech Engn, Tianjin 300134, Peoples R China in 2020.0, Cited 38.0. COA of Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Cattle manure is a kind of abundant agriculture waste but potential renewable resource to be converted into fuel by pyrolysis. The pyrolysis behavior of cattle manure was analyzed by three methods in this work: thermogravimetric analyzer (TG), pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) and pyrolysis photoionization time-of-flight mass spectrometry (Py-PI-TOFMS). The pyrolysis process of cattle manure included four stages, dehydration stage, lignocellulose decomposition stage, lignin and protein decomposition stage, char and mineral matter decomposition stage. The products were mainly classified into six groups: ketones, aldehydes, phenolic compounds, acids, hydrocarbons and N-containing compounds. Based on the time-evolved profiles and temperature-programmed profiles, the characteristics of these major products were analyzed and discussed. Maillard reaction has great effects on the pyrolysis process of cattle manure because cellulose can easily react with protein to produce abundant Amadori products and then generate cyclopentanes and furanmethanol. In addition, some Amadori products and amino acids can also be cyclized to generate N-heterocycle compounds like pyrroles and pyrazines. The decomposition of lignin basic units with more methoxy groups require higher reaction temperature, and the removal of hydroxy and methoxy group on phenols mainly occurred at around 350 degrees C. Furthermore, primary decomposition pathways of cattle manure were also proposed and discussed.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact He, SR; Cao, CC; Wang, JL; Yang, JZ; Cheng, ZJ; Yan, BB; Pan, Y; Chen, GY or concate me.. COA of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Household disaster preparedness in the Islamic Republic of Iran: 2015 estimation WOS:000527367000004 published article about MANAGEMENT; EDUCATION; PROGRAM; RISK in [Ardalan, Ali; Yusefi, Homa] Univ Tehran Med Sci, Sch Publ Hlth, Dept Disaster & Emergency Hlth, Tehran, Iran; [Ardalan, Ali] Harvard Univ, Harvard Humanitarian Initiat, Cambridge, MA 02138 USA; [Yusefi, Homa; Rouhi, Narges; Banar, Ahad] Minist Hlth & Med Educ, Dept Publ Hlth, Disaster Risk Management Off, Tehran, Iran; [Sohrabizadeh, Sanaz] Shahid Beheshti Univ Med Sci, Sch Publ Hlth & Safety, Dept Hlth Disasters & Emergencies, Tehran, Iran in 2020, Cited 25. Computed Properties of C12H12N2O3. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

Background: The Islamic Republic of Iran is at high risk of natural disasters. Households are the basic unit of society and they need to be prepared for disasters. Aims: This study assessed disaster preparedness among Iranian households in 2015. Methods: Using multistage cluster sampling, 2968 households in the catchment area of 53 public health departments in all 30 provinces of the Islamic Republic of Iran were surveyed on the disaster preparedness measures they had taken in the past year. The data collection questionnaire included 15 disaster preparedness measures. The mean preparedness score was calculated and its association with residence (urban versus rural), house ownership (owner versus renter) and education level of the head of the household (illiterate, elementary school, middle school, high school, university) was evaluated. Results: The mean score for household disaster preparedness was 9.3 out of 100 (95% confidence interval: 8.3-10.3). Multivariate analysis showed higher preparedness among rural than urban households (P = 0.02). Higher education level was positively associated with a higher preparedness score (P < 0.001), as was house ownership (P < 0.001). Conclusion: The level of household disaster preparedness in the Islamic Republic of Iran in 2015 was low. In line with the first priority for action of the Sendai Framework for Disaster Risk Reduction, the current study provides an overall picture of household disaster preparedness in the Islamic Republic of Iran. This estimation can be used as a baseline value for policy-making, planning, and evaluation of public awareness of disasters in the country. Computed Properties of C12H12N2O3. About 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, If you have any questions, you can contact Ardalan, A; Yusefi, H; Rouhi, N; Banar, A; Sohrabizadeh, S or concate me.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An article Electrochemical Decarboxylative N-Alkylation of Heterocycles WOS:000577160700037 published article about REDOX-ACTIVE ESTERS; COUPLING REACTIONS; PHOTOREDOX in [Sheng, Tao; Zhang, Hai-Jun; Shang, Ming; He, Chi; Vantourout, Julien C.; Baran, Phil S.] Scripps Res, Dept Chem, La Jolla, CA 92037 USA in 2020.0, Cited 37.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. HPLC of Formula: C5H8N2

An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Sheng, T; Zhang, HJ; Shang, M; He, C; Vantourout, JC; Baran, PS or concate me.. HPLC of Formula: C5H8N2

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Product Details of 83-10-3. Authors Milne, IA; Graham, JMR in CAMBRIDGE UNIV PRESS published article about in [Milne, I. A.] Univ Western Australia, Oceans Grad Sch, Crawley 6009, Australia; [Graham, J. M. R.] Imperial Coll London, Dept Aeronaut, London SW7 2AZ, England in 2019, Cited 13. The Name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid. Through research, I have a further understanding and discovery of 83-10-3

The changes in spectra and intensities of the streamwise component of turbulent velocity are calculated in the inflow of a turbine rotor. The flow is initially calculated in the limit when the turbulence is of small scale compared with the rotor diameter. Rapid distortion theory (RDT), Batchelor & Proudman (Q. J. Mech. Appl. Maths, vol. 7 (1), 1954, pp. 83-103) (BP), for small-scale turbulence is combined with the effect of the fluctuating potential flow field on the turbulence caused by the direct interaction of the incident turbulence with the rotor as a sheet of resistance. A second computation is then carried out for turbulence of larger length scale. The results of the calculations are compared with velocity measurements in the inflow of both a commercial wind turbine and a tidal turbine rotor.

Product Details of 83-10-3. About 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, If you have any questions, you can contact Milne, IA; Graham, JMR or concate me.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Shirshin, KK; Esipovich, AL; Kazantsev, OA; Rumyantsev, M; Korotaev, MS; Rogozhin, AE in [Shirshin, Konstantin K.; Esipovich, Anton L.; Kazantsev, Oleg A.; Rumyantsev, Misha; Korotaev, Mikhail S.; Rogozhin, Anton E.] Nizhnii Novgorod State Tech Univ, 24 Ulitsa Minina Minin St, Nizhnii Novgorod, Russia published Specific Organocatalysis in Amidation Reaction of Fatty Acid Methyl Esters with 3-(Dimethylamino)-1-propylamine in 2021.0, Cited 54.0. Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.

Comparison of various organic compounds such as glycols, amines and alkanolamines as organocatalysts in amidation of fatty acid methyl esters with 3-(dimethylamino)-1-propylamine was made for the first time. It was experimentally detected that catalysts containing OH-groups (alcohols, glycols, glycerol and aminoalcohols) influence the reaction rate. Moreover, catalytic effect is depending on the catalysts geometry significantly. 1,5-diols (e. g. diethylene glycol and diethanolamine) were found to accelerate the reaction more than other OH-groups containing additives. It was supposed, that this catalytic effect is caused by specific associative interactions between reactants and 1,5-diols, what was confirmed by quantum mechanics calculations. Catalysts concentration effects on the reaction rate were also investigated.

Application In Synthesis of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Shirshin, KK; Esipovich, AL; Kazantsev, OA; Rumyantsev, M; Korotaev, MS; Rogozhin, AE or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Asymmetric Construction of Cyclobutanes via Direct Vinylogous Michael Addition/Cyclization of beta,gamma-Unsaturated Amides WOS:000574921100017 published article about 2+2 PHOTOCYCLOADDITION REACTIONS; ENANTIOSELECTIVE SYNTHESIS; CASCADE REACTION; CYCLOADDITION; CATALYSIS; ENALS in [Chen, Yuzhen; Wang, Yichen; Wang, Shuzhong; Zhan, Ruoting; Huang, Huicai] Guangzhou Univ Chinese Med, Res Ctr Chinese Herbal Resource Sci & Engn, Key Lab Chinese Med Resource Lingnan, Minist Educ, Guangzhou 510006, Peoples R China; [Ma, Yan-Yan; Zhao, Deng-Gao] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China in 2020.0, Cited 48.0. COA of Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

The construction of cyclobutanes has attracted much attention because of its unique four-membered ring skeleton. Herein, we report the highly enantioselective direct vinylogous Michael reaction of beta,gamma-unsaturated pyrazole amides and nitroolefin using a squaramide catalyst. Cyclobutane derivatives were obtained by subsequent cyclization in good yields (up to 85%) with excellent enantioselectivities (up to 99% ee). Importantly, the large-scale reaction experiment confirmed the reliability of the vinylogous reaction. Furthermore, the synthetic utility of the vinylogous adducts and cyclobutane derivatives has been realized.

COA of Formula: C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Chen, YZ; Wang, YC; Wang, SZ; Ma, YY; Zhao, DG; Zhan, RT; Huang, HC or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics