Day: May 11, 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 179057-10-4, name is Methyl 4-(1H-pyrazol-5-yl)benzoate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 179057-10-4

Example 168: 1-(4-Benzoyl-2-methyl-piperazin-1-V-)-2-r4-(2H-pyraz?l-3- yl)-phen yli-etha?e-1.2-dio?e; To a solution of 4-(2/-/-pyrazol-3-yl)-benzoic acid methyl ether (0.2 g, 1 mmol) and (4-benzoyl-2-methyl-piperazin-1-yl)-acetonitrile (0.24 g, 1 mmol) in anhydrous THF (2 mL) was added by drops 1.06 M solution LiHMDS in THF (4 mL, 4 mmol). The reaction mixture was stirred for 1 hour, and m-CPBA was added (0.67 g, 4 mmol). The mixture was stirred for 1 hour additionally, quenched with water, extracted with EtOAc, dried over sodium sulfate, filtered and evaporated. The residue was purified by SiO2 chromatography using 10% MeOH/ethyl acetate as eluent to obtain 1-(4-benzoyl-2-methyl-piperazin-1-yl)- 2-[4-(2H-pyrazol-3-yl)-phenyl]-ethane-1,2-dione (0.09 g, 22%). LCMS: CaICd for C23H22N4O3 ? H+: m/z = 403.5. Found: m/z = 403, 404. 1H NMR (DMSO- d6): 13.59 and 13.16 (two br s, 1H, NH-pyrazole); 8.06 (m, 2H); 7.95-7.86 (m, 3H); 7.45-7.40 (m, 5H); 6.89 (br s, 1 H); 4.68-4.30 (br signal, 2 H); 3.29-3.43 (br signal, 2H); 3.16 (m, 1H); 3.08-2.85 (br signal, 2H); 1.20 (br signal,.3H).

The synthetic route of 179057-10-4 has been constantly updated, and we look forward to future research findings.

Application of 214614-81-0,Some common heterocyclic compound, 214614-81-0, name is 4-Bromo-1-(2-hydroxyethyl)pyrazole, molecular formula is C5H7BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 22b (0.45g, 2.36mmol) and bis(pinacolato)diboron (0.718g, 2.83mmol) in DMF (2OmL), was added KOAc (0.694g, 7.08mmol). The mixture was 0 degassed with N2, stirred for 1 Omin and added Pd(dppf)Cl2 (58mg, 0.071 mmol). The mixture was degassed with N2 and stirred at 8O0C overnight. DMF was removed and the residue was purified by column chromatography (EA:PE=1 :10) to afford of 22c (149mg, 26.6% yield).

The synthetic route of 214614-81-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 214614-81-0, These common heterocyclic compound, 214614-81-0, name is 4-Bromo-1-(2-hydroxyethyl)pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of compound 17 (600 mg, 0.242 mmol) and compound 16 (600 mg, 0.926 mmol) was added 2-(4-bromo-1H-pyrazol-1-yl)ethan-1-ol 18 (CAS Reg. No. 214614-81-0, 336 mg, 1.757 mmol) and K2CO3 (607 mg, 4.39 mmol) in dioxane (8 mL) and water (2.000 mL). Nitrogen gas was bubbled through the reaction mixture for 2 min. Then PdCl2(dppf)-CH2Cl2 adduct (154 mg, 0.188 mmol) was added. Nitrogen was bubbled into it for another 1 min. The reaction vessel was sealed and its contents were stirred at 80 C. for 5 h. The reaction mixture was cooled, diluted with ethyl acetate, and filtered. The filtrate was dried over Na2SO4 and concentrated. The crude product was purified by ISCO silica column (40 g), eluted with 20% MeOH in DCM, DCM gradient 0-40%. The desired fractions were concentrated to yield compound 19 (247 mg, 0.565 mmol, 45.0% yield). LCMS ESI: calculated for C23H27N7O3=438.2 (M+H+), found 438.1 (M+H+). 1H NMR (400 MHz, METHANOL-d4) delta 8.00 (s, 1H), 7.84 (s, 1H), 7.53 (d, J=8.1 Hz, 2H), 7.32 (d, J=8.1 Hz, 2H), 5.13 (s, 2H), 4.34 (t, J=6.6 Hz, 2H), 4.26 (s, 2H), 4.14 (s, 3H), 3.92 (t, J=5.4 Hz, 2H), 1.84-1.65 (m, 2H), 1.59-1.37 (m, 2H), 1.00 (t, J=7.5 Hz, 3H).

Statistics shows that 4-Bromo-1-(2-hydroxyethyl)pyrazole is playing an increasingly important role. we look forward to future research findings about 214614-81-0.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide

(Step 1) Preparation of 4-[2-Propoxy-5-(Chlorosulfonyl)Benzamido]-1-Methyl-3-Propyl-5-Carbamoyl Pyrazole To 32.8 ml of chlorosulfonic acid cooled to 0 C., 8.48 ml of thionyl chloride and 20 g of 4-[2-propoxy benzamido]-1-methyl-3-propyl-5-carbamoyl pyrazole were successively added dropwise and portionwise, and then stirred for 2 hours at room temperature. Reaction mixture was added to ice water of 0 C. After 1 hour, the reaction mixture was extracted with ethyl acetate. The organic solution was successively washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain a crude product and triturated with a mixture of hexane:ethyl acetate (10:1) to give 23 g of the title compound. 1H NMR(CDCl3): 0.92(t,3H), 1.08(t,3H), 1.62(m,2H), 1.97(m,2H), 2.50(t, 2H), 4.04(s,3H), 4.32(t,2H), 5.63(br s,1H), 7.24(d,1H), 7.54(br s, 1H), 8.15(dd,1H), 8.93(d,1H), 9.17(br s,1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 920006-32-2, name is 1-Isopropylpyrazole-5-carboxylic Acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 920006-32-2, SDS of cas: 920006-32-2

The 2-Isopropyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide was prepared from 3-nitrobenzoyl chloride using the following multiple step procedure: Step 1: 2-Isopropyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide. A dry flask was charged with 2-Isopropyl-2H-pyrazole-3-carboxylic acid (0.159 g, 1.03 mmol) and thionyl chloride (5 mL) and allowed to stir at 79 C. for 3 h. The thionyl chloride was then removed by concentration in vacuo. The crude acid chloride was cooled to room temperature, and then dissolved in THF (101 mL). 6-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (as prepared in Example 40, 0.260 g, 1.03 mmol) was added to the THF solution of the acid chloride, and the mixture was allowed to reflux overnight. The reaction mixture was then allowed to cool to room temperature and filtered. The solid residue was washed with 0 C. THF and collected to afford the 2-Isopropyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide as a solid (0.328 g, 0.84 mmol, 82%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Isopropylpyrazole-5-carboxylic Acid, and friends who are interested can also refer to it.

Reference of 51516-68-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51516-68-8, name is 5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 5-Amino-1-aryl-1H-pyrazole-4-carbonitriles 1a-j (10 mmol) and SnCl4 (2.3 mL, 20 mmol) were added to a stirred solution of acetylacetone (10 mmol) in dry toluene (20 mL). The reaction mixture was stirred under nitrogen at room temperature for 30 min and then heated under reflux for 5-6 h. The reaction mixture was cooled and poured into water and titrated to pH 12-13 with a saturated aqueous solution of Na2CO3. After filtration, the filtrate was extracted three times with ethyl acetate and the organic layer was dried and evaporated at reduced pressure to give the solid product. The product was purified by silica gel column chromatography and eluted with ethyl acetate/petroleum (1:3, v:v) to give 3a-h and 4a-j.

The chemical industry reduces the impact on the environment during synthesis 5-Amino-1-(3-chlorophenyl)-1H-pyrazole-4-carbonitrile. I believe this compound will play a more active role in future production and life.

Synthetic Route of 51395-52-9,Some common heterocyclic compound, 51395-52-9, name is 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one, molecular formula is C4H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 2-amino-3-quinoxalinethiol (0.177 g, 1 mmol) and the appropriate alpha-haloketones (1 mmol) in glacial acetic acid (10 mL) was heated under reflux for the appropriate time. The solvent was evaporated under reduced pressure and the precipitate was collected and recrystallised from ethanol.

The synthetic route of 51395-52-9 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59843-77-5, name is 3-(3-Nitrophenyl)-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: pyrazoles-derivatives

3-(lH-pyrazol-3-yl)benzenamine (12.B). To a solution of 3-(3-nitrophenyl)- lH-pyrazole 12.A (490 mg, 2.59 mmol, available from Oakwood) in methanol (5 mL) was added 10% Pd on carbon by weight (100 mg). The air was evacuated from the reaction flask and was replaced with hydrogen. The resulting slurry was stirred overnight at room temperature. The reaction mixture was filtered, and the mother liquor condensed to afford 3- (lH-pyrazol-3-yl)benzenamine 12.B (397mg, 96% yield).

The synthetic route of 59843-77-5 has been constantly updated, and we look forward to future research findings.

Reference of 73387-52-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73387-52-7, name is 5-(4-Bromophenyl)-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

In a 40 ml vial, bromo derivative (236 mg, 1.06 mmol, 1.0 eq.), bispinacolotodiboron (253.6 mg, 1.06 mmol, 1.0 eq.), Pd(dppf)CI2 (86.4 mg, 0.106 mmol, 0.1 eq.) and potassium acetate (321.8 mg, 3.17mmol, 3.0 eq.) were mixed in dioxane (10 ml) and heated to 80 C for 48 hours. LCMS indicated that the product was formed in major amount. . The crude reaction was purified in the presence of silica (10-15 gm) and purified using hexanes: ethyl acetate (0-100%) to yield desired boron ester. Theproduct was characterized by reverse phase HPLC using method 4. (ES, m/z) [M +H+] 284.9. Retention time = 1.42 mins

The chemical industry reduces the impact on the environment during synthesis 5-(4-Bromophenyl)-1-methyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Some common heterocyclic compound, 153687-35-5, name is 1-(4-Methoxybenzyl)-1H-pyrazole-4-carbaldehyde, molecular formula is C12H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-(4-Methoxybenzyl)-1H-pyrazole-4-carbaldehyde

General procedure: The aldehyde (4.62 mmol, 1 equivalent) and 2-methylpropane-2-sulfonamide (0.76 g, 5.55 mmol, 1.2 equivalents) were dissolved in anhydrous THF (10 mL) under an atmosphere of nitrogen with stirring. The concentration of the reaction with respect to the aldehyde was 0.46 M. Tris(2,2,2-trifluoroethyl) borate (1.095 mL, 5.09 mmol) was added dropwise to the stirred reaction mixture at room temperature and the reaction was stirred for approximatively 4 days or until UPLC analysis indicated the reaction was complete. The reaction mixture was diluted with EtOAc (50 mL), washed sequentially with a saturated aqueous solution of NaHCO3 (35 mL) and water (35 mL). The organic layer was then dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the product tert-butyl sulfonyl imines. Some of the products were prone to hydrolysis and unstable to flash chromatography, so were used directly in the subsequent cyclisation step unless specified.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 153687-35-5, its application will become more common.