Month: March 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H7N3O2

1000941 To a stirred solution of 3,5-dimethyl-4-nitro-1H-pyrazole 27 (2.0 g, 1.41 mmol) in THF (20 mL), sodium hydride (0.4 g, 60% in mineral oil, 2.82 mmol) was charged at 0C. After stirring for 10 minutes, iodomethane (0.87 mE, 1.41 mmol) was charged and stirred at room temperature for 2 h. The reaction mixture was diluted with water (50 mL) and ethyl acetate (50 mL). The organic layer was dried (Na2SO4), filtered and evaporated to obtain l,3,5-trimethyl-4-nitro-1H-pyrazole 29 (2.1 g, 95% yield). ?HNMR (400 MHz, DMSO-d6): oe 3.77 (s, 3H), 2.59 (s, 311), 2.56 (s, 311).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 14531-55-6.

These common heterocyclic compound, 1572-10-7, name is 3-Amino-5-phenylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Amino-5-phenylpyrazole

To a solution of compound compound 5 (300 mg, 1.83 mmol) in THF (20 mL) was added a .solution of 3-amino-5-phen.ylpyrazole {291 mg, 1.83 mmol) and DlPEA (0.32 mL, 1.83 mmol) in TlIF (8 m_) dropwise at 0 C. After addition, the mixture was stirred at 0 C for additional 60 minutes. TLC was checked and the starting materials were consumed, l-mcthylpipcrazine (0.41 mg. 3.66 mmol) and DlPEA (0.32 mL. 1.83 mmol) was added to the above reaction flak at room temperature. The mixture was stirred at room temperature for overnight. After concentrated to Ethyl acetate (50 ml) and saturated KaHCCh in water were added to the flask. The aq was removed by pipette and silica gel was added. After removal of the organic solvents, the crude product was purified by flash column chromatography on silica gel using DCM/MeOH: 90/10 v/v as eluent to provide compound 15 as white solids (570 mg, 89%). 1H NMR (400 MlIz. DMSOd6) delta 12.72 (br. 111). 9.90 (br, I H), 7.69 ( m. 211) . 7.44 (m, 3H), 6.90 (br. 111). 3.75 (br, 4H), 2.33 (br. 411). 2.19 (overlapped 2 Me. 611); ESl-MS: calcd for(C18II22N8) 350, found 351 (Ml T).

The synthetic route of 3-Amino-5-phenylpyrazole has been constantly updated, and we look forward to future research findings.

Related Products of 27006-76-4,Some common heterocyclic compound, 27006-76-4, name is 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde, molecular formula is C6H7ClN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: All reactions were carried out in vials under nitrogen atmosphere. Step 1: A solution of compound 8 (100 mumol, 1.0 equiv) and compound 9 (150 mumol, 1.5 equiv) in DMF (0.1 M) was treated with K2CO3 (300 mumol, 3.0 equiv) and stirred at 110 C for 16 h (LCMS check). The reaction was filtered and the filtrate concentrated to afford 10. The crude aldehyde 10 (100 mumol, 1.0 equiv) was dissolved in acetone:water (2:1, 0.1 M) and treated with KMnO4 (600 mumol, 6 equiv) and stirred at 30 C for 16 h (LCMS check). The reaction was filtered and the filtrate concentrated to afford 11. The crude acid 11 (100 mumol, 1.0 equiv) was treated with HATU (120 mumol, 1.20 equiv) followed by the crude amine (100 mumol, 1.0 equiv) and NEt3 (300 mumol, 3.0 equiv). The reaction was stirred at 30 C for 16 h (LCMS check). The reactions were concentrated and purified directly by reversed phase preparative HPLC using a C18 column and eluting with acetonitrile-water (0.225% formic acid or pH = 10 NH4OH) gradient. All compounds were deemed greater than 95% purity by LCMS and HPLC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59843-58-2, name is 3-(4-Chlorophenyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., Quality Control of 3-(4-Chlorophenyl)-1H-pyrazole

General procedure: To a 20 ml or 40 ml viale quipped with a stir bar was added photocatalyst, nitrogen nucleophile, iodomesitylene dicarboxylate, copper salt, and ligand. Dioxane was added followed by addition of the base. The solution was sonicated for 1-3 min until it became homogeneous. Next, the solution was degassed by sparging with nitrogen for 5-10 min before sealing with Parafilm. The reaction was stirred and irradiated using two 34-W blue LED lamps (3 cm away, with cooling fan to keep the reaction at room temperature) for 1 h. The reaction mixture was removed from the light, cooled to ambient temperature, diluted with water (15 ml) and ethyl acetate (25 ml), and the aqueous layer was extracted with ethyl acetate (3 ¡Á 25 ml). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on silica gel to afford the desired decarboxylative C-N coupling product. For aniline substrates, a solution of these nitrogen nucleophiles in dioxane was used; additionally, if the iodomesitylene dicarboxylate is a liquid, its solution in dioxane was used.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1082745-50-3, name is 5-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H14N4O2

To a suspension of 0.132 g (0.63 mmol) of 5-amino-1-(tetrahydro-pyran-4-yl)-1-H-pyrazole-4-carboxylic acid amide (see PCT patent application WO2010/026214) in dry EtOH (1.5 mL), 0.066 g (1.66 mmol) of sodium hydride (60% suspension in mineral oil) were added at room temperature under nitrogen. After 10 min, 0.181 mg (0.945 mmol) of Example 13A were added and the reaction mixture was heated to 140 C. for 40 min in a microwave oven (Power 100W). The reaction mixture was then diluted with DCM, water was added, organics separated and dried over sodiumsulphate. Organics were evaporated under reduced pressure and the crude purified by flash chromatography (DCM/IPA 98:2) to obtain the title compound as a white solid. (54 mg, 32%).HPLC-MS (Method 1Eh): Rt=8.01 minMS (APCI pos): m/z=352 (M+H)+ The enantiomers of the title compound were separated by HPLC using a chiral stationary phase.Method for Enantioseparation:Semipreprative Conditions: HPLC semipreparative system: Waters 600 pump; column: Daicel chiralcel OJ-H, 250 mmx20 mm, 5.0 mum; eluent: hexane/EtOH85:15; flow rate: 15 mL/min, Temperature: 25 C.; UV Detection: 254 nm Analytical ConditionsHPLC apparatus type: Agilent 1100; Method 6.1; column: Daicel chiralcel OJ-H, 250 mmx4.6 mm, 5.0 mum; eluent: hexane/EtOH85:15; flow rate: 1 mL/min, Temperature: 25 C.; UVDetection: 254 nm

The synthetic route of 1082745-50-3 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H3N3O4

4-(morpholinomethyl)-phenyl-1,2-diamine (2.3 g, 11.1 mmol), 4-nitro-1H-pyrazole-3-carboxylic acid (1.57 g, 10 mmol), EDC¡¤HCl (2.13 g, 11.1 mmol) and HOBt (1.5 g, 11.1 mmol) were dissolved in anhydrous DMF (25 mL). The solvent was removed under reduced pressure, was added glacial acetic acid (40 mL), heated to reflux for 3 hours, the solvent was removed under reduced pressure, and purified by column (CH2Cl2 / CH3OH (V / V) = 20/1), and then washed with methanol (30mL) to give a solid (0.9g, 27percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5334-40-7, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Safety of 4-Nitro-1H-pyrazole-3-carboxylic acid

A solution of 4-nitro-lH-pyrazole-3-carboxylic acid (1.0 g, 6.4 mmol) in dichloromethane (20 ml) was treated with thionyl chloride (1.4 ml, 19 mmol) and a drop of DMF at ambient temperature. The reaction mixture is stirred at 40¡ãC overnight whereupon another equivalent of thionyl chloride (0.46 ml, 6.4 mmol) was added and stirring was continued at 40¡ãC for another 24h. All volatiles were removed and the acid chloride was suspended in dichloromethane (6 ml) and cooled to 0¡ãC. Triethylamine (4.44 ml, 31.8 mmol) and dimethylamin (4.14 ml, 2M solution in THF) were added. The reaction mixture was allowed to warm-up to ambient temperature and stirring was continued for 3h. The reaction mixture was partitioned between potassium hydrogen sulfate (20 ml, 10percent aqueous solution) and ethyl acetate (40 ml) and extracted. The organic phase was washed with water and brine, dried and the solvent was evaporated. The crude product was triturated with diethylether, sucked off and dried to yield a light brown solid (0.35 g, 30 percent).MS: M = 185.1 (M+H)+

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

Reference of 1260243-04-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of ethyl-5-amino-1H-pyrazole-4-carboxylate 1 (1.0 mmol), an appropriate aldehyde 2 (1.0 mmol) and aterminal alkyne 3 (1.0 mmol) in acetic acid (5 mL) was stirred at 25 C for 10 min. The mixture was then stirred at 60 C under ultrasound using a laboratory ultrasonic bath SONOREX SUPER RK 510H model producing irradiationof 35 kHz for 30 min in the presence of air. The increase of bath temperature beyond 60 C due to the prolonged ultrasound irradiation was controlled by adding cold water time to time. After completion of the reaction the mixture was cooled to room temperature, poured into ethyl acetate (25 mL) and washed with brine solution (2 x 15 mL) followed by 10% NaHCO3 solution (2 x 15 mL). The organiclayer was collected, dried over anhydrous Na2SO4, filteredand concentrated under low vacuum. The residue isolatedwas purified by column chromatography over silica gel using3-8% petroleum ether-EtOAc to give the desired product.

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-amino-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 288-13-1, name is 1H-Pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-13-1, Recommanded Product: 288-13-1

General procedure: Complex 2 (0.05 mmol) was added to a 5 mL of a sealed tube containing the aryl iodide or bromide (0.5 mmol), 1H-pyrazole (0.75 mmol), NaOH (1 mmol), and DMSO (1 mL). The mixture was stirred at 100 C for 12 h. After being cooled to room temperature, the mixture was quenched with 10 mL H2O and extracted with EtOAc(3 ¡Á 20 mL). The combined EtOAc extracts were dried with anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure.The residue was purified by flash column chromatography on silicagel with PE/EtOAc (from 10:1 to 5:1) as the eluent to afford the pure products. All N-aryl pyrazoles reported here are known products and were characterised by 1H NMR, and GC-MS.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 4522-35-4, name is 3-Iodo-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4522-35-4, Formula: C3H3IN2

A mixture of 5-iodo-1H-pyrazole (10 g, 51.55 mmol), 3,4-dihydro-2H-pyran (13 g, 154.55 mmol), TsOH (443 mg, 2.57 mmol) in ethyl acetate (200 mL) was stirred for 3 h at 80 C. The resulting mixture was washed with water. The organic phase was dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under vacuum. The residue was purified by flash chromatography on silica gel eluting with dichloromethane/petroleum ether (3/7) to afford 3-iodo-1-(oxan-2-yl)-1H-pyrazole (7.0 g, 25.18 mmol) as a white solid. LCMS (ESI) [M+H]+=279

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.