Category: 1260672-10-3

Bai, Zhong-Gang et al. published their research in Heterocycles in 2017 | CAS: 1260672-10-3

(5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)methanamine (cas: 1260672-10-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 1260672-10-3

Synthesis of (5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)methanamine was written by Bai, Zhong-Gang;Qi, Hui;Zhang, Qun-Zheng;Ma, Yu;Pan, Qing;Zhang, Xun-Li. And the article was included in Heterocycles in 2017.Recommanded Product: 1260672-10-3 The following contents are mentioned in the article:

This short paper reports the development of a new method for the synthesis of (5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)methanamine. Pyrazole was initially N-protected with the 2-(trimethylsilyl)ethoxymethyl (SEM) group, followed by alkylation at C-5 position with 1-bromo-3-chloropropane. Following SEM deprotection, the intramol. ring was closed and then a bromine atom (Br) was introduced with N-bromosuccinimide (NBS) by electrophilic aromatic substitution (SEAr), forming 3-bromo-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole. The Br group was subsequently converted into aldehyde group, then into oxime. The final step of hydrogenation resulted in the desired product. The overall yield through the 8-step reaction process was found to be 29.4%. This development provides a novel synthetic route to the formation of 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole skeleton. This study involved multiple reactions and reactants, such as (5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)methanamine (cas: 1260672-10-3Recommanded Product: 1260672-10-3).

(5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)methanamine (cas: 1260672-10-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 1260672-10-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics