Category: 1300746-79-5

Computed Properties of C13H8CuF3N2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Iridium-catalyzed silylation of five-membered heteroarenes: high sterically derived selectivity from a pyridyl-imidazoline ligand. Author is Karmel, Caleb; Rubel, Camille Z.; Kharitonova, Elena V.; Hartwig, John F..

The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions that occur with selectivities dictated by steric effects, such as the borylation of C-H bonds, have been poor in many cases. We report that the silylation of five-membered ring heteroarenes occurs with high sterically derived regioselectivity when catalyzed by the combination of [Ir(cod)(OMe)]2 and a phenanthroline ligand or a new pyridylimidazoline ligand that further increases the regioselectivity. The silylation reactions with these catalysts produce high yields of heteroarylsilanes from functionalization at the most sterically accessible C-H bonds of these rings under conditions that the borylation of C-H bonds with previously reported catalysts formed mixtures of products or products that are unstable. The heteroarylsilane products undergo cross-coupling reactions and substitution reactions with ipso selectivity to generate heteroarenes that bear halogen, aryl and perfluoroalkyl substituents.

There is still a lot of research devoted to this compound(SMILES：F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F)Computed Properties of C13H8CuF3N2, and with the development of science, more effects of this compound(1300746-79-5) can be discovered.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand, Author is Karmel, Caleb; Rubel, Camille Z.; Kharitonova, Elena V.; Hartwig, John F., which mentions a compound: 1300746-79-5, SMILESS is F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F, Molecular C13H8CuF3N2, Quality Control of (1,10-Phenanthroline)(trifluoromethyl)copper(I).

The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities dictated by steric effects, such as the borylation of C-H bonds, were poor in many cases. The authors report that the silylation of five-membered-ring heteroarenes occurs with high sterically derived regioselectivity when catalyzed by the combination of [Ir(cod)(OMe)]2 (cod = 1,5-cyclooctadiene) and a phenanthroline ligand or a new pyridyl-imidazoline ligand that further increases the regioselectivity. The silylation reactions with these catalysts produce high yields of heteroarylsilanes from functionalization at the most sterically accessible C-H bonds of these rings under conditions that the borylation of C-H bonds with previously reported catalysts formed mixtures of products or products that are unstable. The heteroarylsilane products undergo cross-coupling reactions and substitution reactions with ipso selectivity to generate heteroarenes that bear halogen, aryl, and perfluoroalkyl substituents.

If you want to learn more about this compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))Quality Control of (1,10-Phenanthroline)(trifluoromethyl)copper(I), you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1300746-79-5).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1300746-79-5, is researched, SMILESS is F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F, Molecular C13H8CuF3N2Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides, Author is Morimoto, Hiroyuki; Tsubogo, Tetsu; Litvinas, Nichole D.; Hartwig, John F., the main research direction is copper trifluoromethylation perfluoroalkylation reagent preparation aryl iodide bromide.Computed Properties of C13H8CuF3N2.

Authors have isolated a trifluoromethylcopper(I) reagent ligated by 1,10-phenanthroline, [(Phen)CuRF] (RF = CF3 (1), CF2CF2CF3 (2)) that reacts with unprecedented range of aryl halides at room temperature to 50°. In comparison to current alternative methods for trifluoromethylation of aryl halides, this system reacts under much milder conditions, tolerates a wider range of functional groups, tolerates basic heterocycles, reacts with more hindered substrates, can be extended to perfluoroalkylation, and occurs with a low total cost of goods. On a more fundamental level, the high reactivity of complexes 1 and 2 with a broad range of iodoarenes demonstrates that a general catalytic perfluoroalkylation of aryl iodides is not limited by the reactivity of the trifluoromethylcopper intermediate.

If you want to learn more about this compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))Computed Properties of C13H8CuF3N2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1300746-79-5).

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Copper-Mediated Trifluoromethylation-Allylation of Arynes, the main research direction is aryl triflate trimethylsilyl allylic bromide copper trifluoromethyl trifluoromethylation allylation; allylarene trifluoromethylated preparation.Related Products of 1300746-79-5.

An unprecedented three-component copper-mediated vicinal trifluoromethylation-allylation of arynes is described. A wide range of structurally diverse trifluoromethylated allylarenes I (R = H, 3-Me, 3-t-Bu, etc.; R1 = H, Me, dimethyl; R2 = Me, Ph, Br, etc.; R3 = H, Me; R4 = H, Me) can be quickly assembled in one step. The application of the method has been demonstrated in the expedient synthesis of the CF3-containing analog of the antispasmodic drug papaverine. The new reactivity of the [CuCF3] reagent, which is generated from the inexpensive industrial byproduct fluoroform, is revealed with unique advantages.

Here is a brief introduction to this compound(1300746-79-5)Related Products of 1300746-79-5, if you want to know about other compounds related to this compound(1300746-79-5), you can read my other articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics