Category: 1300746-79-5

Application In Synthesis of (1,10-Phenanthroline)(trifluoromethyl)copper(I). The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about New Vistas in Transmetalation with Discrete “”AgCF3″” Species: Implications in Pd-Mediated Trifluoromethylation Reactions. Author is Martinez de Salinas, Sara; Mudarra, Angel L.; Benet-Buchholz, Jordi; Parella, Teodor; Maseras, Feliu; Perez-Temprano, Monica H..

This work describes the employment of discrete “”AgCF3″” complexes as efficient transmetalating agents to PdII to surmount overlooked challenges related to the transmetalation step in Pd-catalyzed trifluoromethylation processes. Authors report the participation of a unique silver ate (Cs)[Ag(CF3)2] complex, under stoichiometric and catalytic conditions, in the unprecedented one-pot formation of PhCF3 using PhI as starting material. Moreover, they showed that the transmetalation step, which is often ignored in these transformations, can also determine the success or failure of the coupling process.

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Computed Properties of C13H8CuF3N2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Trifluoromethylation of Arylsilanes with [(phen)CuCF3]. Author is Morstein, Johannes; Hou, Haiyun; Cheng, Chen; Hartwig, John F..

A method for the trifluoromethylation of arylsilanes is reported. The reaction proceeds with [(phen)CuCF3] as the CF3 source under mild, oxidative conditions with high functional-group compatibility. This transformation complements prior trifluoromethylation of arenes in several ways. Most important, this method converts arylsilanes formed by the silylation of aryl C-H bonds to trifluoromethylarenes, thereby allowing the conversion of arenes to trifluoromethylarenes. The unique capabilities of the reported method are demonstrated by the conversion of a C-H bond into a C-CF3 bond in active pharmaceutical ingredients which do not undergo this overall transformation by alternative functionalization processes, including a combination of borylation and trifluoromethylation.

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Application of 1300746-79-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Interrupting the Barton-McCombie Reaction: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates. Author is Liu, Zhi-Yun; Cook, Silas P..

The site-selective trifluoromethylation of aliphatic systems remains an important challenge. A light-driven, copper-mediated trifluoromethylation of O-alkyl thiocarbonates was described for the synthesis of trifluoromethyl-alkanes. The reaction provided broad functional group tolerance (e.g., alkyne, alkene, phenol, free alcs., electron-rich and -deficient arenes), thereby offering orthogonality and practicality for trifluoromethylation. A radical organometallic mechanism was proposed.

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Name: (1,10-Phenanthroline)(trifluoromethyl)copper(I). So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about CuO-catalyzed conversion of arylacetic acids into aromatic nitriles with K4Fe(CN)6 as the nitrogen source.

CuO was demonstrated to be effective as the catalyst for the conversion of arylacetic acids to aromatic nitriles ArCN [Ar = Ph, 2-MeC6H4, 1-naphthyl, etc.] with non-toxic and inexpensive K4Fe(CN)6 as the nitrogen source via the complete cleavage of the C≡N triple bond. The present method allowed a series of arylacetic acids including phenylacetic acids, naphthaleneacetic acids, 2-thiopheneacetic acid and 2-furanacetic acid to be converted into the targeted products in low to high yields.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)(SMILESS: F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F,cas:1300746-79-5) is researched.HPLC of Formula: 17190-29-3. The article 《Radical Anions of Trifluoromethylated Perylene and Naphthalene Imide and Diimide Electron Acceptors》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:1300746-79-5).

A series of electron-deficient perylene and naphthalene imides and diimides with varying degrees of trifluoromethylation were synthesized. Single crystal X-ray anal. afforded detailed structural information, while spectroelectrochem. and EPR spectroscopy provided characterization of the radical anions . This study reveals that trifluoromethylation of the imides and diimides makes their one-electron reduction potentials substantially more pos. relative to the unsubstituted counterparts, while their other properties remain largely unchanged.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1300746-79-5, is researched, SMILESS is F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F, Molecular C13H8CuF3N2Journal, Article, Beilstein Journal of Organic Chemistry called Comparative profiling of well-defined copper reagents and precursors for the trifluoromethylation of aryl iodides, Author is Kaplan, Peter T.; Lloyd, Jessica A.; Chin, Mason T.; Vicic, David A., the main research direction is aryltrifluoromethyl preparation; aryl iodide copper reagent trifluoromethylation; benchmarking; copper; fluorine; fluoroalkylation; trifluoromethylation.Name: (1,10-Phenanthroline)(trifluoromethyl)copper(I).

A number of copper reagents e.g., I were compared for their effectiveness in trifluoromethylating 4-iodobiphenyl, 4-iodotoluene, and 2-iodotoluene. Yields over time were plotted in order to refine our understanding of each reagent performance, identify any bottlenecks, and provide more insight into the rates of the reactions. Interestingly, differences in reactivity were observed when a well defined [LCuCF3] complex I was employed directly or generated in situ from precursors by published reports. Relative reactivities were also found to highly dependent on the nature of the iodoarenes.

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Synthetic Route of C13H8CuF3N2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Computational characterization of a mechanism for the copper-catalyzed aerobic oxidative trifluoromethylation of terminal alkynes. Author is Jover, Jesus; Maseras, Feliu.

A reaction mechanism for the copper(i)-catalyzed oxidative aerobic trifluoromethylation of terminal alkynes has been determined by DFT calculations The transmetalation of CF-3 to copper appears to be a ligand replacement process independent of the metal. The dioxygen activation follows the sequence η1-superoxocopper(ii), μ-η2:η2-peroxodicopper(ii) and bis(μ-oxo)-dicopper(iii).

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Kitson, Russell R. A.; Moody, Christopher J. published an article about the compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)( cas:1300746-79-5,SMILESS:F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F ).Electric Literature of C13H8CuF3N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1300746-79-5) through the article.

The toxicity associated with the geldanamycin (I) family of benzoquinone ansamycins when used as heat shock protein-90 inhibitor mol. therapeutics is ameliorated by substitution at the 19-position. The resulting 19-substituted derivatives have greater potential for success in oncol. clin. trials and for other medicinal purposes such as the treatment of neurodegenerative conditions. Having overcome hurdles associated with the sensitivity and complexity of these mols., through a variety of synthetic approaches, the synthesis of a series of 19-substituted geldanamycin derivatives is reported herein using optimized Stille and Suzuki coupling reactions. Further compounds were accessible via copper-mediated coupling and nucleophilic addition reactions. He new compounds are of significant medicinal interest, in view of their significantly reduced toxicity previously observed for this class of substrate compared to their 19-unsubstituted counterparts that have been evaluated in the clinic.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)( cas:1300746-79-5 ) is researched.Product Details of 1300746-79-5.Dibrell, Sara E.; Maser, Michael R.; Reisman, Sarah E. published the article 《SeO2-Mediated Oxidative Transposition of Pauson-Khand Products》 about this compound( cas:1300746-79-5 ) in Journal of the American Chemical Society. Keywords: bicyclic cyclopentenone oxidative transposition selenium dioxide mediated. Let’s learn more about this compound (cas:1300746-79-5).

Oxidative transpositions of bicyclic cyclopentenones I [R1 = Me, Ph, n-hexyl, 3-pyridyl, etc.; R2 = H, Me; R3 = H, Me, Ph; R32 = (CH2)5, CH2CH2NBocCH2CH2; X = O, NBoc, C(CO2Et)2, C(CO2i-Pr)2] mediated by selenium dioxide (SeO2) has been disclosed. Treatment of Pauson-Khand (PKR) reaction products I with SeO2 in the presence or absence of water furnished the corresponding di- and trioxidized cyclopentenones II and III [from I (R2 = H)], resp. Mechanistic investigations revealed multiple competing oxidation pathways that depend on substrate identity and water concentration Functionalization of the oxidized products via cross-coupling methods demonstrated their synthetic utility. These transformations allows rapid access to oxidatively transposed cyclopentenones from simple PKR products.

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Computed Properties of C13H8CuF3N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen)CuRF]. Author is Litvinas, Nichole D.; Fier, Patrick S.; Hartwig, John F..

A versatile method for the synthesis of aryl perfluoroalkanes from arenes and aryl bromides is described. Substituted arenes or aryl bromides are converted in situ to aryl boronate esters that readily undergo perfluoroalkylation in air with [(phen)CuRF]. A broad range of aryl bromide substrates was perfluoroalkylated in good yield for the first time. [(Phen)CuCF3] is now com. available and has been prepared on 20 g scale.

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