These common heterocyclic compound, 537039-17-1, name is 5-(4-Methylpiperazin-1-yl)-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H15N5
Step 5: A mixture of N-[3-(3-dimethylamino-acryloyl)-phenyl]-3-trifluoromethyl-benzamide (40 mg, 0.22 mmol) and 5-(4-Methyl-piperazin-1-yl)-2H-pyrazol-3-ylamine (37 mg, 0.20 mmol) in 2 mL of acetic acid is heated at 80 C. over night. Then the reaction mixture is concentrated and diluted with ethyl acetate. N-{3-[2-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}-3-(trifluoromethyl)benzamide (67.3 mg, 70% yield) is obtained by reverse phase chromatography purification. HPLC: Rt=2.0 min; MS 481 [M+H]MS (electrospray): m/z 481.2 [M+H]
The synthetic route of 5-(4-Methylpiperazin-1-yl)-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wyeth; US2007/219186; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics