Synthetic Route of 2820-38-4, A common heterocyclic compound, 2820-38-4, name is 3,5-Dimethyl-1H-pyrazol-4-ol, molecular formula is C5H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3,5-dimethyl- lH-pyrazol-4-ol (386 mg, 3.44 mmol), N-( – bromopropyl)phthalimide (1.16 g, 3.78 mmol), Cs2C03 (2.24 g, 6.88 mmol) and acetone (20 mL) was heated at reflux for 16 h. The mixture was filtered and concentrated under reduced pressure to give a thick oil, which was purified by flash chromatography (90% EtOAc/petroleum spirits) gave the title compound (290 mg, 25%). 1H NMR (400 MHz, CDC13) delta 2.07 (2 H, dd, 7 13.6, 6.4 Hz, CH2CH2N), 2.19 (6 H, s, 2 x CH3), 3.86 (4 H, td, 7 6.6, 4.7 Hz, CH2N,CH20), 7.67 (2 H, dd, 7 5.4, 3.1, AR), 7.81 (2 H, dd, 7 5.5, 3.1 HZ, Ar);13C NMR (100 MHz, CDC13) delta 9.85, 29.24, 35.43, 72.04, 123.25, 132.13, 133.99, 134.61, 138.93, 168.39; HRMS (ESI+): m/z 300.1341 [M+H]+ (calcd. [Ci6Hi7N303+H]+ 300.1343).
The synthetic route of 2820-38-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH; THE UNIVERSITY OF MELBOURNE; WILLIAMS, Spencer John; JARROTT, Bevyn; (94 pag.)WO2016/149765; (2016); A1;,
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