Category: 10250-59-6

10250-59-6, name is Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate

c. Synthesis of 1 ,3-dimethyl-pyrazole-5-carboxylic acid; 3,delta-dimethyl-pyrazole-delta-carboxylic acid methylester (5.14 Kg) is added to an aqueous solution of 20% sodium hydroxide (10 L) at O0C. The reaction mixture is stirred at room temperature for 18 hours and cooled to O0C. Concentrated hydrochloric acid (4.2 L) is then added to the reaction mixture in over 7 hours. The resulting thick slurry is stirred at room temperature for 18 hours. The mixture is filtered, and the solids are washed with water (500 mL), and dried in a vacuum oven for 18 hours (700C and 26 mm Hg) to provide 3.8 Kg of 1 ,3- dimethyl-pyrazole-delta-carboxylic acid (81 % yield with a purity of >97 % by HPLC).

The synthetic route of 10250-59-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; WO2006/48761; (2006); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 10250-59-6, name is Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H10N2O2

Example 1 : Preparation of N-(2,5-dimethyl-2H-pyrazol-3-ylmethyl)-4-(5-trifluormethyl- pyridin-2-yloxy)-benzenesulfonamide (Table I: example 1-21 )Example 1.1 : Preparation of (2,5-dimethyl-2H-pyrazol-3-yl)-methanol At 25 to 300C 25 ml of a 1 molar solution of lithium aluminium hydride in diethylether was added dropwise to 4.5 g 2,5-dimethyl-2H-pyrazole-3-caboxylic acid methyl ester in 50 ml diethylether. A solid precipitated and the reaction mixture was stirred for about 2 to 3 days at about 20 to 25C. After dilution of the reaction mixture with 50 ml of MTBE a little volume of water was added. After filtration the precipitated wet solid was thoroughly washed with ethyl acetate. The solvent was removed in vacuo from the combined filtrate and washing fluids to yield 3.7 g of the title compound. 1H-NMR (CDCI3, delta in ppm): 5.9 (s, 1 H); 4.6 (s, 2H); 4.0 (s, broad, 1 H); 3.75 (s, 3H); 2.2 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10250-59-6, its application will become more common.

Reference:
Patent; BASF SE; WO2009/101082; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics