Application of 6833-82-5,Some common heterocyclic compound, 6833-82-5, name is Methyl 5-(trifluoromethyl)pyrazole-3-carboxylate, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under a nitrogen atmosphere, 0.59 g of N-bromosuccinimide was added to a mixture of 0.58 g of 3-trifluoromethyl-1H-pyrazole-5-carboxylic acid methyl ester and 10 mL of DMF, and the mixture was stirred at 60 C. for 1 day. To the obtained mixture, 1M aqueous sodium thiosulfate solution and saturated aqueous sodium hydrogen carbonate solution were added, and the mixture was extracted with tert-butyl methyl ether. The obtained organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography (hexane: ethyl acetate = 2: 1) to obtain 0.53 g of intermediate A-7 represented by the following formula. I
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-(trifluoromethyl)pyrazole-3-carboxylate, its application will become more common.