Some common heterocyclic compound, 1207961-59-8, name is 2-(4-Fluoro-1H-pyrazol-1-yl)ethanol, molecular formula is C5H7FN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H7FN2O
Methanesulfonyl chloride (16.8 g, 11.4 mL, 147 mmol) was added to a solution of compound 6a (13.4 g, 98 mmol), diisopropylamine (34.3 mL, 196 mmol), and 4-(dimethylamino)-pyridine (1.2 g, 9.78 mmol) in dichloromethane (245 mL) in an ice bath. The reaction was warm to room temperature and stirred at room temperature for 2 h. Water (50 mL) was added to quench the reaction. The organic layer was dried, filtered, and concentrated to get a brown oil. This oil residue was purified by silica gel chromatography (0?60% EtOAc in hexane) to give compound 6b (19.5 g, 96% yield) as a yellowish oil. 1H NMR (400 MHz, CDCl3-d) delta ppm 2.89 (s, 3H), 4.33-4.38 (m, 2H), 4.53-4.59 (m, 2H), 7.38 (d, J=1.52 Hz, 1H), 7.40 (d, J=1.01 Hz, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1207961-59-8, its application will become more common.