Reference of 112779-14-3, These common heterocyclic compound, 112779-14-3, name is Ethyl 5-amino-1-(tert-butyl)-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Production Example 28-1; Ethyl 5- (lH-pyrrol-1-yl)-l-t-butyl-lH-pyrazole-4- carboxylate; 8.45 g of ethyl 5-amino-l-t-butyl-lH-pyrazole-4- carboxylate was dissolved in 60 ml of acetic acid, and 7.93 g of 2,5-dimethoxytetrahydrofuran was then added. The mixture was heated to reflux for 2 hours. The reaction mixture was concentrated under reduced. pressure. After water was added, the residue was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 8.95 g of ethyl 5-(lH-pyrrol-l-yl)-l-t-butyl-lH-pyrazole-4- carboxylate. 1H-NMR (CDCl3, TMS, 8 (ppm)) : 1.11 (3H, t), 1.46 (9H, s), 4.08 (2H, q), 6.33 (2H, t), 6.70 (2H, t), 7.93 (1H, s)
The synthetic route of 112779-14-3 has been constantly updated, and we look forward to future research findings.