Electric Literature of 118054-57-2, The chemical industry reduces the impact on the environment during synthesis 118054-57-2, name is 2-(1H-Pyrazol-3-yl)acetic acid hydrochloride, I believe this compound will play a more active role in future production and life.
Example 94. Synthesis of 3-fluoro-2-(4-(3-(2-hydroxyethyl)-lH-pyrazol-l-yl)-5- oxo-6,7- ihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)benzonitrile, 1-94 Synthesis of compound 94.2. To a solution of 94. 1 (lg, 6.1mmol, l .Oeq) in THF (lOmL) was added LAH (lm ) (24.6g, 24.6mmol, 4eq) at 0C. Reaction mixture was stirred at room temperature for 4h. Upon completion of reaction, mixture was transferred into sodium sulphate decahydrate and filtered on celite bed the washed with ethyl acetate and filtrate was concentrated under reduced pressure to obtain crude, which was purified by column chromatography to furnish 94.2 . (0.5g, 72.49%). MS(ES): m/z 113.35 [M+H]+
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