Category: 181585-93-3

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181585-93-3 as follows. name: Methyl 5-nitro-1H-pyrazole-3-carboxylate

[0567] To a solution of 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (200 mg, 1.17 mmol) in dry THF (10 mL) was added LiBH4 (2.34 mL, 2 M in THF) at 0 C, and the resulting mixture was allowed to warm to room temperature and stirred overnight. The reaction was monitored by TLC. Then the reaction was quenched with H20 (10 mL), and the mixture was extracted with EtOAc (20 mL x3). The combined organic layers were concentrated in vacuum to afford (5-nitro-lH-pyrazol-3-yl)-methanol (154 mg, yield: 92%) as a white solid. [0568] 1H MR (400 MHz, DMSO-6): delta = 13.89 (brs, 1H), 6.86 (d, J = 1.6 Hz, 1H), 5.57 (brs, 1H), 4.53 (s, 2H).

According to the analysis of related databases, 181585-93-3, the application of this compound in the production field has become more and more popular.

Synthetic Route of 181585-93-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 181585-93-3 name is Methyl 5-nitro-1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of methyl 3-nitro-lH-pyrazole-5-carboxylate(A59, 25.0 g, 146.19 mmol) in methanol(500 mL) was added Pd/C(3.80 g, 36.54 mmol) under N2 atmosphere and the reaction mixture was stirred under H2 balloon pressure at room temperature for 4 h. After completion of reaction mixture filtered through celite bed and washed with EtOAc. The filtrate was concentrated to dryness. The residue was washed with n-pentane dried to get methyl 3-amino-lH-pyrazole-5-carboxylate A60 as a pale yellow solid. Yield: 18.0 g(87%) LC-MS(ES) m/z : 142.16[M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-nitro-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181585-93-3, name is Methyl 5-nitro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 181585-93-3

Step 12: Preparati -Methyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester A 100-mL single-neck round-bottomed flask was charged with methyl 5-nitro-lH-pyrazole-3- carboxylate (3.89 g, 22.7 mmol), anhydrous DMF (30 ml) , potassium carbonate (6.28 g, 45.5 mmol). Mel (4.19 g, 1.85 ml, 29.6 mmol) was added and the reaction mixture was stirred at room temperature for 18h. The mixture was then diluted with water (150 mL) and extracted with DCM (3 x 75mL). The combined organic layers were dried over MgS04 and concentrated under vacuum. The crude material was purified by flash chromatography (silica gel, AnaLogix system, SF40-240g column, 10% to 50% EtOAc in hexanes) to give the desired product as mixture of isomers (3.75 g). M+ = 185.0 m/e

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.