Category: 1572-10-7

Electric Literature of 1572-10-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-10-7, name is 3-Amino-5-phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

3-Amino-5-phenyl pyrazole (477 mg) and ethyl 2-N,N-dimethylaminomethylene acetoacetate (556 mg) were dissolved in ethanol (10 ml) and stirred at 70C for 1.5 hours. The reaction mixture was added conc. hydrochloric acid (1 mg), and was stirred for additional 1 hour. The mixture was cooled to room temperature and concentrated under reduced pressure. Ethanol (10 ml) and 5 N aqueous sodium hydroxide solution (3 ml) were added to the residues and then stirred at 70C for 1 hour. After cooling to room temperature, water and ethyl acetate were added to the mixture. 2 N hydrochloric acid was added to the aqueous phase until it became acidic, and precipitated crystals were collected and washed with water and n-hexane to give 3f (463 mg, Y.: 61%) as yellow crystals.1H NMR: d 3.2 (3H, s), 7.4 (1H, s), 7.5 (3H, m), 8.1 (2H, d), 8.9 (1H, s), 13.6 (1H, brs); MS (m/z): 252 (M-H)-.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-5-phenylpyrazole. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1572-10-7, name is 3-Amino-5-phenylpyrazole, A new synthetic method of this compound is introduced below., Product Details of 1572-10-7

General procedure: The general method was described for the synthesis of D1. Compound C1 (150 mg, 0.393 mmol) was dissolved in ethanol (2 mL),followed by addition of 5-phenyl-1H-pyrazol-3-amine (62.63 mg, 0.393 mmol) and triethylamine (119.43 mg, 1.18 mmol). The mixture was stirred at room temperature for 5 h. The resultant mixture was purified by column chromatography to give D1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 1572-10-7,Some common heterocyclic compound, 1572-10-7, name is 3-Amino-5-phenylpyrazole, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The general method was described for the synthesis of D1. Compound C1 (150 mg, 0.393 mmol) was dissolved in ethanol (2 mL),followed by addition of 5-phenyl-1H-pyrazol-3-amine (62.63 mg, 0.393 mmol) and triethylamine (119.43 mg, 1.18 mmol). The mixture was stirred at room temperature for 5 h. The resultant mixture was purified by column chromatography to give D1.

The synthetic route of 1572-10-7 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-10-7, name is 3-Amino-5-phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., name: 3-Amino-5-phenylpyrazole

General procedure: N,N-Diisopropylethylamine (3.0-4.0 eq) was added to 8-methoxyquinoline-3-carboxylic acid (1.0 eq) in solvent (dichloromethane, tetrahydrofuran,or N,N-dimethylformamide, 0.05 to 0.2 M) at room temperature. Then, 1-((dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V)(1.0-1.5 eq) was added and the reaction mixture was stirred for five minutes. Then, amine (1.0 – 2.0 eq) was added and the reaction mixture was stirred for one to sixteen hours. 10% Aqueous citric acid was added and the reaction mixture was extracted with dichloromethane, washed with saturated sodium bicarbonate, dried over magnesium sulfate, filtered,and concentrated. The resulting residue was purified by RP HPLC or silica gel chromatography to give the quinoline-3-carboxamide (1%-95% yield).

According to the analysis of related databases, 1572-10-7, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 1572-10-7, name is 3-Amino-5-phenylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Amino-5-phenylpyrazole

To a solution of compound compound 5 (300 mg, 1.83 mmol) in THF (20 mL) was added a .solution of 3-amino-5-phen.ylpyrazole {291 mg, 1.83 mmol) and DlPEA (0.32 mL, 1.83 mmol) in TlIF (8 m_) dropwise at 0 C. After addition, the mixture was stirred at 0 C for additional 60 minutes. TLC was checked and the starting materials were consumed, l-mcthylpipcrazine (0.41 mg. 3.66 mmol) and DlPEA (0.32 mL. 1.83 mmol) was added to the above reaction flak at room temperature. The mixture was stirred at room temperature for overnight. After concentrated to Ethyl acetate (50 ml) and saturated KaHCCh in water were added to the flask. The aq was removed by pipette and silica gel was added. After removal of the organic solvents, the crude product was purified by flash column chromatography on silica gel using DCM/MeOH: 90/10 v/v as eluent to provide compound 15 as white solids (570 mg, 89%). 1H NMR (400 MlIz. DMSOd6) delta 12.72 (br. 111). 9.90 (br, I H), 7.69 ( m. 211) . 7.44 (m, 3H), 6.90 (br. 111). 3.75 (br, 4H), 2.33 (br. 411). 2.19 (overlapped 2 Me. 611); ESl-MS: calcd for(C18II22N8) 350, found 351 (Ml T).

The synthetic route of 3-Amino-5-phenylpyrazole has been constantly updated, and we look forward to future research findings.