Category: 86477-09-0

These common heterocyclic compound, 86477-09-0, name is Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 86477-09-0

Add 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid ethyl ester (3.10 g, 17.2 mmol) and 30 mL of water to a 100 mL vial and cool to 0 C.Add sodium hydroxide solid (4.8 g, 86.0 mmol), stir to dissolve,Transfer to room temperature for 3 h, TLC detection reaction is completed,Wash once with 30 mL of DCM, adjust the pH of the aqueous phase to about 5 with concentrated hydrochloric acid.A white solid is precipitated and suction filtered to obtain a part of the product.The filtrate was extracted 3 times with 50 mL of EA, and the organic phases were combined and dried over anhydrous sodium sulfate.Filtered, concentrated,A total of 1.7g of light yellow solid, a yield of 65%,

The synthetic route of Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Lin Xinglong; Xie Hongming; Hu Yangxiao; Li Shiguang; Zhang Yingjun; Tan Yumei; Yuan Mingyun; (124 pag.)CN108948019; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 86477-09-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 86477-09-0 as follows.

Example 162a 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic Acid 162a A 25-mL round-bottomed flask equipped with a reflux condenser was charged with ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate (540 mg, 3.0 mmol), 2N Aqueous sodium hydroxide solution (3.5 mL), and 1,4-dioxane (3.0 mL). The system was heated at 65 C. for 2.5 h. It was then cooled to room temperature and adjusted the pH to 2-3 with concentrated HCl. The solid was collected by filtration to afford 162a (260 mg, 57%) as a yellow solid. MS-ESI: [M+H]+ 153.3

According to the analysis of related databases, 86477-09-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Wei, BinQing; Young, Wendy B.; US2013/116246; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 86477-09-0, name is Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 86477-09-0

Add 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid ethyl ester (3.10 g, 17.2 mmol) and 30 mL of water to a 100 mL vial and cool to 0 C.Add sodium hydroxide solid (4.8 g, 86.0 mmol), stir to dissolve,Transfer to room temperature for 3 h, TLC detection reaction is completed,Wash once with 30 mL of DCM, adjust the pH of the aqueous phase to about 5 with concentrated hydrochloric acid.A white solid is precipitated and suction filtered to obtain a part of the product.The filtrate was extracted 3 times with 50 mL of EA, and the organic phases were combined and dried over anhydrous sodium sulfate.Filtered, concentrated,A total of 1.7g of light yellow solid, a yield of 65%,

The synthetic route of Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate has been constantly updated, and we look forward to future research findings.