Category: 51516-70-2

Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H7FN4

5-Amino-i -(4-fluorophenyl)-i H-pyrazole-4-car- boxamide (Step 1, 900 mg, 4.45 mmol) was added dropwise to sulfuric acid (10 mE) at 0 C. The resulting solution was stirred for 2 hat 25 C. The pH of the solution was adjusted to 8 by the addition of sodium carbonate (10% aqueous). The resulting mixture was extracted with dichloromethane (4×50 mE) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to provide 5-amino-i -(4-fluorophenyl)- 1H-pyrazole-4-car- boxamide which was used in Step 3 without further purification. ECMS: (ESI) mlz 221 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51516-70-2, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 51516-70-2

General procedure: (General method). Amixture of the appropriate aminonitrile 1 (3.0 mmol) and1,3-dicarbonyl compound (3.0 mmol) in anhydrous toluene(12 ml) was refluxed for 1 h in a flask equipped with aDean-Stark trap. Tin(IV) chloride (3.0 g, 11.5 mmol) wasadded to the reaction mixture, and refluxing was continuedfor additional 5-6 h. A resinous precipitate was formed,andthe colorless toluene layer was decanted. The residualsolvent was removed on a rotary evaporator, the obtainedglassy solids were dissolved in boiling dioxane, cooled, thenpoured into a solution of Na23 (4.0 g) in water (70 ml).The precipitate that formed was filtered off, washed withwater, dried, and recrystallized from a 5:1 mixture of2-PrOH-DMF.

The synthetic route of 51516-70-2 has been constantly updated, and we look forward to future research findings.

Related Products of 51516-70-2,Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The experimental procedure was similar to synthesis of analogs1(aei). 5-amino-1-aryl-1H-pyrazole-4-carbonitriles 4(aei)(0.001 mol) were reacted with 2.0 mL of 1,3-diaminopropane andcarbon disulfide (0.004 mol). The temperaturewas 85-95oC and thereaction time was 14-16 hours. The reaction mixture was pouredinto cold water, the precipitate was filtered out and washed withcold water. The reactions were accompanied by means of TLC anddichloromethane as eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

Application of 51516-70-2,Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Intermediate 4 (1mmol) and the intermediate 7 (1mmol) were dissolved in ethanol to the glass flask, then HCl solution was added as a catalyst refluxed at 80C for 15-18h. After the TLC monitoring reaction was completed, the mixture was vacuum filtered and concentrated. Finally, the above crude product can be isolated and purified by column chromatography (Hexane/EtOAc=8:1) to obtain target compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

Reference of 51516-70-2,Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 5-amino-1-phenyl-1H-pyrazole-4-carbonitriles (7-12)(0.01 mol) and 20 mL of formic acid was stirred and allowed to reflux for 12 h. The reaction mixture was poured into 50 mL of ice-cold water. The precipitate was collected by filtration and washed with water to produce 13-18 in 68-89% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.