Category: 116008-52-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 116008-52-7, name is 4-Amino-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C4H5N3O2

EXAMPLE 125 Trans-3-(naphth-2-yl)-but-2-enoic acid-N-(3-carboxy-1H-pyrazol-4-yl)-amide Prepared analogously to Example 31 from trans-3-(naphth-2-yl)-but-2-enoic acid chloride and 4-amino-1H-pyrazol-3-carboxylic acid in dimethylformamide with the addition of pyridine.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Boehringer Ingelheim Pharma KG; US6362210; (2002); B1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 116008-52-7,Some common heterocyclic compound, 116008-52-7, name is 4-Amino-1H-pyrazole-3-carboxylic acid, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Amino acid 4 (2 g, 0.0157 mol) wassuspended in absolute EtOH (20 ml). SOCl2 (1.17 ml,1.92 g, 0.0161 mol) was added dropwise to the suspension.The mixture was heated under reflux for 12 h untilhomogenization. A cherry-colored solution formed. Thesolvent was evaporated to dryness under reduced pressureon the rotary evaporator. The solid residue was dried in avacuum desiccator to constant weight. Yield 3.0 g (99%),pink solid, mp 114-115C. 1H NMR spectrum (400 MHz, DMSO-d6), delta, ppm (J, Hz): 10.22 (4, br. s, NH, +NH3);8.03 (1H, s, -3 pyrazole); 4.28 (2, q, J = 7.0,OCH2H3); 1.30 (3, t, J = 7.1, OCH2H3). 13C NMRspectrum (101 MHz, DMSO-d6), delta, ppm: 160.5; 133.7;127.3; 116.6; 60.8; 14.1. Found, m/z: 178.05868 [M+Na]+.C6H9N3NaO2. Calculated, m/z: 178.05870.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Amino-1H-pyrazole-3-carboxylic acid, its application will become more common.