Category: 127107-23-7

Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Product Details of 127107-23-7

1. 5.0 kg of l-methyl-pyrazol-4-amine hydrochloride and 9.2 kg of water were added to a flask (“Flask 1”). 2. The contents of Flask 1 were stirred at 15-25 C until dissolved. 3. 9.6 kg of tert-butyl 4-(2-chloropyrimidin-4-yl)-2-methylbenzylcarbamate, 15.6 kg of 2-butanol, and 14.6 kg of water were added to a separate flask (“Flask 2”). 4. The contents of Flask 2 were stirred at 55-65 C until a clear solution was observed. 5. The contents of Flask 1 were added to Flask 2, rinsing Flask 1 with 5 kg of water and transferring the rinse to Flask 2. 6. The contents of Flask 2 were heated to 80-90 C and were stirred at 80-90 C for at least 16 hours. 7. The contents of Flask 2 were cooled to 30-40 C. 8. 46.1 g of water was added to Flask 2 while maintaining the temperature at 30-40 C. 9. 24.2 kg of ammonium hydroxide (28-30%) was diluted with 25.7 kg of water and added to Flask 2 over at least 1 hour. 10. 5 kg of water was added to Flask 2. 11. The contents of Flask 2 were cooled to 10-20 C over at least 1 hour. 12. The contents of Flask 2 were stirred at 10-20 C for at least 1 hour. 13. The contents of Flask 2 were vacuum filtered to isolate a solid product. 14. The product was dried under vacuum at < 75 C. 15. 7.65 kg of product was obtained (90.0% yield), and MR conformed to prior assignments. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Synthetic Route of 127107-23-7,Some common heterocyclic compound, 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, molecular formula is C4H8ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00664] Synthesis of compound 1-94. To a 20-mL sealed microwave tube containing compound 112.5 (120 mg, 0.27 mmol, 1.00 equiv), 1 -methyl- lH-pyrazol-4-amine hydrochloride (77.7 mg, 0.58 mmol, 2.10 equiv) in 5 mL of isopropanol was added 0.02 mL of hydrochloric acid (4 M in dioxane) at room temperature. The reaction mixture was heated on microwave for 2.5 h at 140 C and resulting solids were collected by filtration. Crude collected was purified via flash column chromatography to give 72.2 mg (53%) of compound 1-94 as a off- white solid. LCMS (ES, m/z): 498 [M+H]+. 1H NMR(400MHz, <-DMSO): delta 8.94 (s, IH), 7.80 (s, IH), 7.46 (s, IH), 5.75-5.60 (s, IH), 4.65 (s, 2H), 34.08-3.95 (m, IH), 3.80 (s, 3H), 3.59 (t, 4H), 2.85 (s, 2H), 2.52 (s, 4H), 2.30-2.22 (m, IH), 2.10 (d, 2H), 1.92 (d, 2H), 1.55-1.32 (m, 4H), 1.28 (s, 6H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-4-amine hydrochloride, its application will become more common.

Reference of 127107-23-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2-(6-((2,5-dichloropyrimidin-4-yl)amino)hexahydrofuro[3,2-b]furan-3-yl)isoindoline-1,3-dione (370.0 mg, 0.88 mmol) and 1-methyl-1H-pyrazol-4-amine hydrochloride (354.2 mg, 2.65 mmol) were dissolved in n- BuOH (10 mL) and DIPEA (683.1 mg, 5.29 mmol). The reaction mixture was stirred at 150 C overnight and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (MeOH / CH2Cl2 (v / v) = 1/30) to give the title compound as a red solid (140.0 mg, 33.1%).

The synthetic route of 1-Methyl-1H-pyrazol-4-amine hydrochloride has been constantly updated, and we look forward to future research findings.

Electric Literature of 127107-23-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

Step 4) fert-butyl 5-((5-chloro-2-((l-methyl-lH-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)-5- (cvanomethyl)hexahydrocvclopentarc1pyrrole-2(lH)-carboxylate [0464] To a suspension of tert-butyl 5-(cyanomethyl)-5-((2,5-dichloropyrimidin-4-yl)amino) hexahydrocyclopenta[c]pyrrole-2(lH)-carboxylate (631.5 mg, 1.53 mmol) and 1-methyl-lH- pyrazol-4-amine hydrochloride (213.2 mg, 1.60 mmol) in -BuOH (10 mL) was added Et3N (322.1 mg, 3.18 mmol). The reaction mixture was stirred at 150 C in a sealed tube overnight and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/50) to give the title compound as a yellow solid (283.0 mg, yield 39.1%). LC-MS (ESI, pos. ion) m/z: 473.3 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Methyl-1H-pyrazol-4-amine hydrochloride

To a solution of tert-butyl ((1S,5R,6R)-3-(2-chloro-5-fluoropyrimidin-4-yl)-6-methyl-3-azabicyclo[3.1.0]hexan-1-yl)carbamate (42, 1.0 g, 2.91 mmol) in isopropanol (10 mL) was added 1-methyl-1H-pyrazol-4ylamine hydrochloride (506 mg, 3.79 mmol) and the reaction was heated to 140 C under microwave irradiation for 1 h. The resulting solid was filtered and dried to afford (1S,5R,6R)-3-(5-fluoro-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-6-methyl-3-azabicyclo[3.1.0]hexan-1-amine hydrochloride (43, 991 mg, 86%). MS m/z 304 [M+H]+

According to the analysis of related databases, 127107-23-7, the application of this compound in the production field has become more and more popular.