Category: 37687-24-4

Related Products of 37687-24-4, These common heterocyclic compound, 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 10A Diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate 5 g (23.6 mmol) of diethyl 1H-pyrazole-3,5-dicarboxylate were dissolved in 100 ml of acetone, and 6.3 g (23.6 mmol) of 2-bromo-2,4-dichloroacetophenone and 3.6 g (26 mmol) of potassium carbonate were added. The mixture was stirred at RT for 12 h. The reaction mixture was concentrated and the residue was taken up in water and dichloromethane. The organic phase was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated on a rotary evaporator. The residue was triturated with diethyl ether, and the solid was filtered off with suction. This gave 9.48 g (94% of theory) of the product as a solid. LCMS (method 6): Rt=2.34 min. (m/z=399 (M+H)+) 1H-NMR (400 MHz, DMSO-d6): delta=8.02 (d, 1H), 7.84 (s, 1H), 7.68 (dd, 1H), 7.35 (s, 1H), 6.13 (s, 2H), 4.32 (q, 2H), 4.26 (q, 2H), 1.31 (t, 3H), 1.25 (t, 3H).

The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Diethyl 3,5-pyrazoledicarboxylate

NaOH (3.53 g, 88 mmol) was added to a solution of diethyl 1H-pyrazole-3,5- dicarboxylate (5.35 g, 25.2 mmol) in acetonitrile (40 mL). After 30 mi 2- chloroethanamine hydrochloride (3.22 g, 27.7 mmol) and tetrabutylammonium hydrogen sulfate (0.43 g, 1.26 mmol) were added. The mixture was refluxed for 20 h. Aftercooled, conc. HC1 (5 mL) was added. The mixture was extracted with CH2C12, washed with brine. The combined organic layers were dried over Na2SO4, filtered and concentrated. Normal phase chromatography afforded Intermediate 138 (2.72 g, 52%) as a white solid. ?H NMR (500MHz, DMSO-d6) oe 8.39 (br s, 1H), 7.07 (s, 1H), 4.40 (dd, J6.7, 5.5 Hz, 2H), 4.27 (q, J7.2 Hz, 2H), 3.68 – 3.61 (m, 2H), 1.28 (t, J=7.0 Hz, 3H).LC-MS(ESI) m/z: 210.1 [M+H].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.