Category: 67-51-6

In 2021.0 ORG LETT published article about ASYMMETRIC ALPHA-AMINATION; VINYLOGOUS ALDOL REACTION; ELECTROPHILIC AMINATION; HIGHLY REGIO; KETONES; ACCESS; ENALS; BONDS in [Fu, Xin; Duan, Abing] Hunan Univ, Coll Environm Sci & Technol, Changsha 410082, Peoples R China; [Fu, Xin; Hao, Yu; Bai, He-Yuan; Zhang, Shu-Yu] Shanghai Jiao Tong Univ, Key Lab Thin Film & Microfabricat Technol, Minist Educ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; [Fu, Xin; Hao, Yu; Bai, He-Yuan; Zhang, Shu-Yu] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China in 2021.0, Cited 62.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. COA of Formula: C5H8N2

A cobalt-catalyzed regio- and enantioselective gamma-amination of beta,gamma-unsaturated N-acylpyrazoles that delivers the corresponding gamma-amination products in good regio- and enantioselectivity has been established. Moreover, the nitrogen-containing compounds could be easily synthesized. DFT calculations have been provided to explain regio- and enantioselectivity for this gamma-amination. The chiral gamma-amination products were readily converted into the chiral gamma-amino acid derivatives.

COA of Formula: C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Fu, X; Hao, Y; Bai, HY; Duan, AB; Zhang, SY or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Recently I am researching about SOL-GEL COATINGS; MILD-STEEL; DERIVATIVES; ACID; PROTECTION, Saw an article supported by the Azarbaijan Shahid Madani University. SDS of cas: 67-51-6. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Masoumi, A; Sadr, MH; Soltani, B. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole

A series of pyrazole ligands named as 1,4-bis(3,5-dimethylpyrazol-1-yl)butane (bbd), 1,3-bis(3,5-dimethylpyrazol-1-yl)propane (bdpp), and 1,3-bis(3,5-dimethylpyrazol-1-yl)propane-2-ol (bdpo) along with their transition metal complexes including [Cu-2(mu(3)-SCN)(2)(mu-bbd)](n), [Cu-2(mu(3)-SCN)(2)(mu-bdpp)](n), and [Cu2Hg(mu(2)-SCN)(2)(bdpo)(2)(CH3COO)(2)](n)were synthesized and characterized using FT-IR and Uv-vis spectroscopies, as well as thermal gravimetric analysis. The prepared compounds were investigated as corrosion inhibitors to protect mild steel in 0.5 M H(2)SO(4)solution. Corrosion tests were performed by electrochemical impedance spectroscopy and potentiodynamic polarization measurements. The pyrazole ligands exhibited inhibition efficiencies in a range of 38-78%, which introduced them as moderate inhibitors. On the other hand, the pyrazole complexes showed inhibition efficiencies higher than 85%, demonstrating their high potentials to mitigate the steel corrosion. In addition, the bimetallic complex resulted in higher corrosion resistance than the two monometallic complexes. This was evidence of a critical role of the coordinated metal of the complex in forming an adhesive protection film on the steel surface.

SDS of cas: 67-51-6. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Masoumi, A; Sadr, MH; Soltani, B or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Nonmetallic Pentazole Salts Based on Furazan or 4-Nitropyrazole for Enhancing Density and Stability WOS:000648580100014 published article about EINES KLASSISCHEN PROBLEMS; PI-STACKING; CHEMISTRY; ANION; CYCLO-N-5(-) in [Hu, Wei; Yang, Hongwei; Chen, Jieyi; Zhang, Chong; Sun, Chengguo; Hu, Bingcheng; Cheng, Guangbin] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China in 2021.0, Cited 36.0. Recommanded Product: 67-51-6. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

In this work, three novel nonmetallic pentazole salts (6-8) based on furazan or 4-nitropyrazole were synthesized. Some coplanar groups were introduced into the compounds to improve the planarity of the crystal packing. 4-Amino-1,2,5-oxadiazole-3-carbohydrazonamide pentazolate (6), 5-(4-amino-1,2,5-oxadiazol-3-yl)-4H-1,2,4-triazole-3,4-diamine pentazolate (7), and 5,5′-(4-nitro-1H-pyrazole-3,5- diyl)-bis(4H-1,2,4-triazole-3,4-diamine) pentazolate (8) all show more stable pi-pi stacking and exhibit superior thermal stability (110.5-116.4 degrees C) than most other reported nonmetallic pentazole salts (T-onset: 80-110 degrees C), and compound 8 has the highest crystal density (1.722 g.cm(-3)/173 K) of nonmetallic pentazole salts to date. All salts have been thoroughly characterized by NMR (H-1 and C-13) spectroscopy, infrared (IR), Roman (RA), and elemental analysis. The decomposition temperature of all salts displays more than 110 degrees C, which is measured by differential scanning calorimetry (DSC). These compounds all shows low sensitivity (IS > 35 J, FS > 360 N) measured by standard BAM methods. Glycidyl azide polymer (GAP) based propellant formula with the addition of salt 6 or 7 shows a higher specific impulse (6, I-sp = 262.1 s; 7, I-sp = 263.9 s) than that of RDX (I-sp = 259.0 s). This study can provide a new crystal engineering way for the synthesis of pentazole salt to solve the problem of low density and poor stability.

About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Hu, W; Yang, HW; Chen, JY; Zhang, C; Sun, CG; Hu, BC; Cheng, GB or concate me.. Recommanded Product: 67-51-6

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Oxidation of sulfides in aqueous media catalyzed by pyrazole-oxidoperoxido-molybdenum(VI) complexes WOS:000552643400003 published article about MOLYBDENUM(VI) COMPLEXES; MOLECULAR-STRUCTURE; METAL DERIVATIVES; OXYGEN-TRANSFER; SULFOXIDES; CHEMISTRY; PYRAZOLE; CRYSTAL; POLY(PYRAZOLYL)ALKANES; COORDINATION in [Bruno, Sofia M.; Amarante, Tatiana R.; Paz, Filipe A. Almeida; Pillinger, Martyn; Valente, Anabela A.; Goncalves, Isabel S.] Univ Aveiro, Dept Chem, CICECO Aveiro Inst Mat, Campus Univ Santiago, P-3810193 Aveiro, Portugal in 2020.0, Cited 39.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Recommanded Product: 3,5-Dimethyl-1H-pyrazole

The complex [MoO(O-2)(2)(pyrazole)(2)] (1) is an effective catalyst for the oxidation of organic sulfides (methyl-phenylsulfide and diphenylsulfide). Reactions can be run in water as the only medium, at low temperature (25 degrees C), with low catalyst loadings (0.2 mol%) and excellent H2O2 efficiency with no significant non-productive decomposition of the oxidant. Under conditions that favor sulfone formation, the overall process, including isolation of the precipitated product (by filtration or centrifugation) and recycling of the aqueous phase con-taining the catalyst, can be performed in the absence of organic or ionic liquid solvents. Catalytic results with the recycled aqueous phase were the same as those obtained in the first cycle. With water as the sole solvent, 1 is a superior catalyst to the 3,5-dimethylpyrazole complexes [MoO(O-2)(2)(dmpz)(2)] (2) and [Hdmpz](4)[Mo8O25.8(O-2)(0.2)(dmpz)(2)]center dot 4H(2)O (3). Crystal structures for 1 and 3 are presented.

Recommanded Product: 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Bruno, SM; Amarante, TR; Paz, FAA; Pillinger, M; Valente, AA; Goncalves, IS or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

An article Triazole based azo molecules as potential antibacterial agents: Synthesis, characterization, DFT, ADME and molecular docking studies WOS:000529345400014 published article about DISAZO DYES; SPECTROSCOPIC PROPERTIES; ABSORPTION; DESIGN; DRUG; 1,2,3-TRIAZOLE; APPROXIMATION; ANTIFUNGAL; MOIETIES; PYRAZOLE in [Gokalp, Merve; Dede, Bulent; Tilki, Tahir] Suleyman Demirel Univ, Fac Sci & Arts, Dept Chem, TR-32260 Isparta, Turkey; [Atay, Cigdem Karabacak] Mehmet Akif Ersoy Univ, Fac Educ, Dept Basic Educ, TR-15030 Burdur, Turkey in 2020.0, Cited 40.0. Computed Properties of C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

In this study, three triazole based azo molecules [3-amino-4-[1H-1,2,4-triazole-3-yldiazenyl]-1H-pyrazole-5-ol (1), 3-[(3,5-dimethyl-1H-pyrazole-4-yl)diazenyl]-1H-1,2,4-triazole (2) and 4-[1H-1,2,4triazole-3yldiazenyl]benzene-1,3-diol (3)] were, synthesized and characterized by using 1H NMR, FTIR, UV-vis and mass spectra. The molecular structure, vibrational spectroscopic data, electronic transition absorption wavelengths, HOMOs and LUMOs analyses, molecular electrostatic potential (MEP) and potential energy surface (PES) diagrams were calculated by using DFT/B3LYP method with 6-311G(d,p) basis set. NMR chemical shift calculations were performed by using the gauge-invariant atomic orbital (GIAO) method. The spectroscopic results obtained from quantum chemical calculations of the 1, 2 and 3 molecules were in good agreement with the experimental data. Antibacterial activities of the 1, 2 and 3 were investigated against four different bacterial cultures. Although 1 molecule did not show very good antibacterial activity, 2 and 3 showed good activity against Staphylococcus aureus at a MIC of 250 and 62.5 mg/mL, respectively. Druglikeness and some of the pharmacokinetic properties of the 1, 2 and 3 were also examined. In addition, molecular docking studies were performed to investigate the antibacterial properties of synthesized compounds by in silico method. For this purpose, beta-ketoacyl-acyl carrier protein (ACP) synthase III (KAS III) and lipoteichoic acid synthase (LtaS) inhibitory properties of 1, 2 and 3 molecules were investigated. Although all of the synthesized compounds showed antibacterial properties according to the results of the molecular docking studies, the best results were obtained by the compound 3 which interacts with both KAS III and LtaS with binding energy of -7.17 and -7.53 kcal/mol, respectively. (C) 2020 Elsevier B.V. All rights reserved.

Computed Properties of C5H8N2. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Gokalp, M; Dede, B; Tilki, T; Atay, CK or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Related Products of 67-51-6, These common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To an 8 mL dram vial was added iodobenzene diacetate (0.6 mmol, 1.5 equiv), and heteroarene(0.4 mmol, 1 eq.), anhydrous dichloroethane (1 mL), then chloride source (5 equiv). The solutionwas allowed to stir (1000 rpm) at 50 C for the indicated amount of time. After which the solutionwas washed with saturated sodium bicarbonate, followed by saturated sodium thiosulfate andconcentrated. The crude mixture was then purified by column chromatography.

Statistics shows that 3,5-Dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 67-51-6.

Reference:
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 67-51-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: SOCl2 (5 mL) was added to a round-bottom flask, and then 1a-i(1.0 mmol) and a catalytic amount of DMF (0.1 mmol) were added. Themixture was heated to reflux for 4 h (reaction monitored by HPLC),then excess SOCl2 was evaporated under reduced pressure. The residuewas dispersed in H2O (200 mL) and extracted with AcOEt. The organicphase was separated, dried, and concentrated. It was then purified byflash column chromatography (eluent: ethyl acetate/petroleum ether,1 : 10 v/v) to afford 2a-i.

The chemical industry reduces the impact on the environment during synthesis 3,5-Dimethyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Li, Yi; Liu, Yuanyuan; Xu, Guanghui; Chen, Kai; He, Guangke; Huang, Bin; Journal of Chemical Research; vol. 38; 11; (2014); p. 658 – 661;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H8N2

(1000mg, 10.40mmol) and KOH (1675mg, 10.40mmol) was dissolved in DMSO, and the resulting heterogeneous solution was stirred at 80 1.5h, then cooled to room temperature. Then, added over 15 minutes a solution of 6M DMSO (876mg, 15.61mmol), and the reaction mixture was stirred for 2.5 hours. TLC observation to monitor whether the reaction is complete. The reaction was dissolved in water, the aqueous phase with CHCl3 extraction. The combined organic layers were washed with 100ml of water, dried over anhydrous Na2SO4, dried and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel, eluting with 20% ethyl acetate in petroleum ether. To give a yellow oil.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 67-51-6.

Reference:
Patent; Southern Medical University; Cheng Kui; Xu Yao; (20 pag.)CN109867662; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 67-51-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

3,5-Dimethyl-1H-pyrazole, 78.5 g (0.818 mol), was dissolved in 700 mL of water heated to 70°C, and 517 g (3.271 mol) of potassium permanganate was added to the hot solution, maintaining the temperature no higher than 90°C. The mixture was cooled to room temperature, the precipitate of MnO2 was filtered off and washed with water, and the filtrate was acidified with aqueous HCl to pH 2 and left overnight. The precipitate was filtered off and washed with water. Yield 41.75 g (33percent), white crystals, mp 257?258°C. 1H NMR spectrum: delta 7.07 ppm, s (1H, 4-H). 5-Methyl-1H-pyrazole-3-carboxylic acid (2). The aqueous filtrate obtained after separation of diacid 1, was neutralized to pH 5?6, and the precipitate of 2 was filtered off and washed with water. Yield 18.1 g (18percent), white crystals, mp 210?211°C. 1H NMR spectrum, delta, ppm: 2.25 s (3H, CH3), 6.42 s (1H, 4-H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kharaneko; Russian Journal of Organic Chemistry; vol. 52; 9; (2016); p. 1322 – 1325; Zh. Org. Khim.; vol. 52; 9; (2016); p. 1334 – 1337,4;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 67-51-6, These common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250 ml reaction vessel, 3,5-dimethyl-1 H-pyrazole x51 (0.5 g, 5 mmol), I2 (0.79 g, 30 mmol) and CAN (1.71 g, 3 mmol) are dissolved in 70 ml of CH3CN and stirred at room temperature for 16 h. The solvent is evaporated, the residue dissolved in AcOEt and washed with a 10 % aqueous solution of Na2S2U3 and brine. The aqueous phase is re- extracted with AcOEt and the combined organic phases are dried over Na2SO4, filtered and concentrated to dryness to afford 1.15 g (100 %) of crude 4-iodo-3,5-dimethyl-1 H- pyrazole x52, which is used in the next step without further purification.LC-MS (MH+): 223.

Statistics shows that 3,5-Dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 67-51-6.

Reference:
Patent; UCB S.A.; WO2006/128692; (2006); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics