Category: 930-36-9

Quality Control of 1-MethylpyrazoleOn May 1, 2022 ,《Phosphine-free ruthenium complexes supported by a pincer ligand bearing 1,2-dihydropyrimidine for Oppenauer-type oxidation of secondary alcohols》 appeared in Journal of Organometallic Chemistry. The author of the article were Zhou, Jun; Luo, Shubiao; Liu, Hongming; Xue, Peng. The article conveys some information:

Treatment of the (diethylaminomethyl-picolyl)pyrazolium (A3) with NaOH in dichloromethane affords the pincer ligand (L) bearing a 1,2-dihydropyrimidine unit. Reaction of [RuCl2(DMSO)4] and the ligand (L) affords the complex [RuCl2(L)(DMSO)] (Ru1). Removal of the chlorides from Ru1 with either NaBF4 or KPF6 in CH3CN produces the complexes [Ru(L)(CH3CN)3](BF4)2 (Ru2) and [Ru(L)(CH3CN)3](PF6)2 (Ru3), resp. Ru2 has been characterized with X-ray crystallog. All of the new ruthenium complexes (Ru1-Ru3) are catalytically active in the Oppenauer-type oxidation of secondary alcs. Among them, the complex Ru1 is the most active. Steric effects were observed from the outcome of substituted acetophenones. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Quality Control of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Quality Control of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zhang, Lingtian; Moccia, Marialuisa; Briggs, David C.; Bharate, Jaideep B.; Lakkaniga, Naga Rajiv; Knowles, Phillip; Yan, Wei; Tran, Phuc; Kharbanda, Anupreet; Wang, Xiuqi; Leung, Yuet-Kin; Frett, Brendan; Santoro, Massimo; McDonald, Neil Q.; Carlomagno, Francesca; Li, Hong-yu published an article on January 27 ,2022. The article was titled 《Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose》, and you may find the article in Journal of Medicinal Chemistry.Application of 930-36-9 The information in the text is summarized as follows:

Mutations of the rearranged during transfection (RET) kinase are frequently reported in cancer, which make it as an attractive therapeutic target. Herein, we discovered a series of N-trisubstituted pyrimidine derivatives as potent inhibitors for both wild-type (weight) RET and RETV804M, which is a resistant mutant for several FDA-approved inhibitors. The X-ray structure of a representative inhibitor with RET revealed that the compound binds in a unique pose that bifurcates beneath the P-loop and confirmed the compound as a type I inhibitor. Through the structure-activity relationship (SAR) study, compound 20 (I) was identified as a lead compound, showing potent inhibition of both RET and RETV804M. Addnl., compound 20 displayed potent antiproliferative activity of CCDC6-RET-driven LC-2/ad cells. Anal. of RET phosphorylation indicated that biol. activity was mediated by RET inhibition. Collectively, N-trisubstituted pyrimidine derivatives could serve as scaffolds for the discovery and development of potent inhibitors of type I RET and its gatekeeper mutant for the treatment of RET-driven cancers. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Application of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ul′yanovskii, Nikolay V.; Kosyakov, Dmitry S.; Popov, Mark S.; Shavrina, Irina S.; Ivakhnov, Artem D.; Kenessov, Bulat; Lebedev, Albert T. published their research in Microchemical Journal on December 31 ,2021. The article was titled 《Rapid quantification and screening of nitrogen-containing rocket fuel transformation products by vortex assisted liquid-liquid microextraction and gas chromatography – high-resolution Orbitrap mass spectrometry》.Safety of 1-Methylpyrazole The article contains the following contents:

Existing and newly developed technologies for clean-up of wastewaters and soils contaminated with rocket fuel unsym. dimethylhydrazine (UDMH) are based on the oxidative treatment, as well as gasification in supercritical water. Being easily transformed by a radical mechanism, UDMH is capable of producing an extremely wide range of potentially hazardous nitrogen-containing products. Their identification and simultaneous quantification at low concentrations in water samples by gas chromatog. is a challenging task requiring a matrix change. We proposed a combination of dispersive vortex-assisted liquid-liquid microextraction (VALLME) of analytes followed by gas chromatog. – Orbitrap mass spectrometry allowing simultaneous target anal. and non-targeted screening. Dichloromethane and chloroform provided rapid (10 min) and effective extraction of most of UDMH transformation products. The maximum recoveries were achieved by alkalizing and saturating the aqueous samples with ammonium sulfate. The use of pyridine-d5 as an internal standard allowed developing an approach to the simultaneous determination of 24 compounds of various classes with detection limits for the most analytes in the range 0.02-1.1 μg L-1 and accuracy of 81-117% with low-cost, simple, and rapid sample preparation procedure. Extraction with a 100 μL of chloroform allowed further increasing sensitivity up to one order of magnitude and attaining LOD values for 20 compounds in the range of 0.002-0.1 μg L-1 comparable with that obtained by vacuum-assisted headspace solid-phase microextraction The developed method was validated and tested for the analyses of real samples – degraded aqueous solution of rocket fuel, products of UDMH treatment in supercritical water and aqueous extract of soil from the place of carrier rocket accidental crash. Twenty-nine compounds that were not previously described as UDMH transformation products were tentatively identified.1-Methylpyrazole(cas: 930-36-9Safety of 1-Methylpyrazole) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Safety of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kudashev, Anton; Baudoin, Olivier published their research in Chemistry – A European Journal on December 15 ,2021. The article was titled 《Site-Selective Pd-Catalyzed C(sp3)-H Arylation of Heteroaromatic Ketones》.Related Products of 930-36-9 The article contains the following contents:

A ligand-controlled site-selective C(sp3)-H arylation of heteroaromatic ketones had been developed using Pd catalysis to gave ArC(O)CHR1CH2R2 [Ar = thiazol-2-yl, 2-pyridyl, 2-quinolyl, etc.; R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = H, Me, ph, etc.]. The reaction occurred selectively at the α- or β-position of the ketone side-chain. The switch from α- or β-arylation was realized by addition of a pyridone ligand. The α-arylation process showed broad scope and high site- and chemoselectivity, whereas the β-arylation was more limited. Mechanistic investigations suggested that α-arylation occurs through C-H activation/oxidative addition/reductive elimination whereas β-arylation involves desaturation and aryl insertion. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Related Products of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Hayashi, Hiroki; Takano, Hideaki; Katsuyama, Hitomi; Harabuchi, Yu; Maeda, Satoshi; Mita, Tsuyoshi published an article in Chemistry – A European Journal. The title of the article was 《Synthesis of difluoroglycine derivatives from amines, difluorocarbene, and CO2: computational design, scope, and applications》.Application In Synthesis of 1-Methylpyrazole The author mentioned the following in the article:

A three-component reaction (3CR) for the synthesis of difluoroglycine derivatives has been achieved by using amines, difluorocarbene (generated in situ), and the abundant, inexpensive, and nontoxic C1 source CO2. Various tert-amines and pyridine, (iso)quinoline, imidazole, thiazole, and pyrazole derivatives were incorporated, and the corresponding products were isolated in solid form without purification by column chromatog. on silica gel. Detailed reaction profiles of the 3CR were obtained from computational anal. using DFT calculations, and the results critically suggest that simple ammonia is not applicable to this reaction. In addition, as strongly supported by computational predictions, a new reagent that can generate difluorocarbene at 0°C without any additives was discovered. Finally, radical substitution reactions of the obtained difluoroglycine derivatives under photoredox conditions, as well as a synthetic application as an N-heterocyclic carbene ligand are shown. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Application In Synthesis of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application In Synthesis of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

O’Sullivan, Leonie; Patel, Ketul V.; Rowley, Ben C.; Brownsey, Duncan K.; Gorobets, Evgueni; Gelfand, Benjamin S.; Van Humbeck, Jeffrey F.; Derksen, Darren J. published an article on January 7 ,2022. The article was titled 《Regioselective Synthesis of C3-Hydroxyarylated Pyrazoles》, and you may find the article in Journal of Organic Chemistry.Product Details of 930-36-9 The information in the text is summarized as follows:

The first regioselective route to C3-hydroxyarylated pyrazoles obtained through reaction of pyrazole N-oxides with arynes using mild conditions is reported. Importantly, this method does not require the C4 and C5 positions of the pyrazole to be functionalized to observe regioselectivity. Using this method, authors completed the synthesis of a recently reported JAK 1/2 inhibitor. Authors’ synthesis produces the desired product in 4 steps from com. available starting materials. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Product Details of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 1-MethylpyrazoleOn November 30, 2019 ,《Catalyst-free addition of secondary phosphine chalcogenides to pyrazolecarbaldehydes》 appeared in Mendeleev Communications. The author of the article were Malysheva, Svetlana F.; Kuimov, Vladimir A.; Belogorlova, Natalia A.; Gusarova, Nina K.; Taydakov, Ilya V.; Albanov, Alexander I.; Eremenko, Igor L.; Trofimov, Boris A.. The article conveys some information:

(Chalcogenophosphoryl)hydroxymethyl-substituted pyrazoles were obtained by catalyst-free reaction between 4- and 5-pyrazolecarbaldehydes and secondary phosphine chalcogenides R2P(X)H [R = Ph, (CH2)2Ph, X = O, S, Se] at 23-50° in toluene. In the experiment, the researchers used many compounds, for example, 1-Methylpyrazole(cas: 930-36-9Reference of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Palladium-Phenylpyrazolylphosphine-Catalyzed Cross-Coupling of Alkenyl Pivalates》 was written by Chen, Zicong; So, Chau Ming. Name: 1-Methylpyrazole And the article was included in Asian Journal of Organic Chemistry on April 30 ,2021. The article conveys some information:

A new type of easily accessible phenylpyrazole phosphine ligand was developed. The catalyst generated from Pd(OAc)2 and PP-Phos was highly effective in the palladium-catalyzed cross-coupling of alkenyl pivalates with organomagnesium reagents. The reaction accommodated a broad scope of alkenyl carboxylates under mild conditions, providing an alternative but practical way to the synthesis of multi-substituted alkenes, e.g., I in value. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Name: 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Name: 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Bukenov, Bauyrzhan; Baimatova, Nassiba; Kenessov, Bulat published an article on January 31 ,2022. The article was titled 《Quantification of transformation products of rocket fuel unsymmetrical dimethylhydrazine in air using solid-phase microextraction》, and you may find the article in Journal of Separation Science.COA of Formula: C4H6N2 The information in the text is summarized as follows:

Quantification of unsym. dimethylhydrazine transformation products in ambient air is important for assessing the environmental impact of heavy rocket launches. There are little data of such analyses, which is mainly caused by the low number of analytes covered by the available anal. methods and their complexity. A simple and cost-efficient method for accurate simultaneous determination of seven unsym. dimethylhydrazine transformation products in air using solid-phase microextraction followed by gas chromatog.-mass spectrometry was developed. The method was optimized for air sampling and solid-phase microextraction from 20-mL vials, which allows full automation of anal. The extraction for 5 min by Carboxen/polydimethylsiloxane fiber from amber vials and desorption for 3 min provided the greatest analytes’ responses, lowest relative standard deviations, linear calibration (R2 ≥ 0.99), and limits of detection from 0.12 to 0.5μg/m3. Samples with concentrations 500μg/m3 can be stored at 21 ± 1° without substantial losses (1-11%) for up to 24 h, while air samples with concentrations 10 and 50μg/m3 stored for up to 24 h can be used for accurate quantification of only two and four out of seven analytes, resp. The developed method was successfully tested for the anal. of air above real soil samples contaminated with unsym. dimethylhydrazine rocket fuel. In the experimental materials used by the author, we found 1-Methylpyrazole(cas: 930-36-9COA of Formula: C4H6N2)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. COA of Formula: C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Fuse, Shinichiro; Suzuki, Kensuke; Kuchimaru, Takahiro; Kadonosono, Tetsuya; Ueda, Hiroki; Sato, Shinichi; Kizaka-Kondoh, Shinae; Nakamura, Hiroyuki published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity》.Name: 1-Methylpyrazole The author mentioned the following in the article:

In this study, indeno[2,1-c]pyrazolones, compounds I [Y = C, N; R1 = H, Me; R2 = H, Me, Ph, etc] were designed as readily available synthetic inhibitors of HIF-1 transcriptional activity. Nine compounds were synthesized in 4-5 steps from com. available starting materials. In evaluations of the ability to inhibit the hypoxia-induced transcriptional activity of HIF-1, compound I [Y = C, R1 = H, R2 = 4-MeC6H4] showed a higher level compared with that of known inhibitor, YC-1. The compound I [Y = C, R1 = H, R2 = 4-MeC6H4] suppressed HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Name: 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Name: 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics