Category: 930-36-9

Kublicki, Marcin; Ogonowski, Blazej; Wieczorkowski, Dariusz; Durka, Krzysztof; Klis, Tomasz published an article in Tetrahedron Letters. The title of the article was 《1,4-Phenylenebis((1-methyl-1H-pyrazol-5-yl)borinic 8-oxyquinolinate) as a photoredox catalyst in the atom transfer radical addition of iodoperfluoroalkanes to alkenyl groups bearing organoboron compounds》.Reference of 1-Methylpyrazole The author mentioned the following in the article:

The key photocatalytic properties of a transition-metal-free heteroleptic complex I (1) derived from 1,4-phenyldiboronic acid were evaluated. This compound was utilized in the atom transfer radical addition of iodoperfluoroalkanes CnF2n+1I (n = 1-4) to a series of allylic arylboronate compounds CH2:CHCH2XAr[B] [X = bond, O, CH2; Ar = phenylene, thiophenediyl; [B] = B(OH)2, BF3K] to give C-I activation products, [B]ArXCH2CHICH2CnF2n+1 (2-14). The products of these reactions retained the B-C bond, and Suzuki-Miyaura coupling of one product gave biphenyl derivatives The X-ray anal. of one of the obtained perfluoroalkylated boronic acids revealed the presence of open star-shaped channels. In the experiment, the researchers used many compounds, for example, 1-Methylpyrazole(cas: 930-36-9Reference of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Reference of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《One-step preparation of ammonium-specified pyrazolium ionic liquids unveil the more popular pathway for the CO2 fixation: Integrated experimental and theoretical studies》 was written by Zhu, Xinrui; Zhang, Jingshun; Zhang, Zhengkun; Liu, Fang; Hu, Yuhang; Liu, Yi; Ren, Tiegang; Wang, Li; Zhang, Jinglai. Computed Properties of C4H6N2 And the article was included in Journal of Molecular Liquids on April 15 ,2021. The article conveys some information:

Amino-specified pyrazolium ionic liquid (APEPzBr) is synthesized by two steps. It is interesting that the product of the first step ([EPzPNH3]Br2) could also catalyze the coupling reaction of carbon dioxide and epoxides under 70°C along with 0.5 MPa CO2 pressure, which is even more benign than APEPzBr. It is attributed to the strong ability of [EPzPNH3]Br2 to absorb CO2 along with robust electrophilic activation, which is testified by d. functional theory and 13C NMR measurement. The difference between [EPzPNH3]Br2 and APEPzBr is further elucidated by electron localization function (ELF) and atoms in mols. (AIM). After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Computed Properties of C4H6N2)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Computed Properties of C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

HPLC of Formula: 930-36-9On June 7, 2019, Iida, Keisuke; Ishida, Shunsuke; Watanabe, Takamichi; Arai, Takayoshi published an article in Journal of Organic Chemistry. The article was 《Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds》. The article mentions the following:

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives In addition to this study using 1-Methylpyrazole, there are many other studies that have used 1-Methylpyrazole(cas: 930-36-9HPLC of Formula: 930-36-9) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. HPLC of Formula: 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Quality Control of 1-MethylpyrazoleOn March 25, 2021, Shi, Xinzhe; Sosa Carrizo, E. Daiann; Cordier, Marie; Roger, Julien; Pirio, Nadine; Hierso, Jean-Cyrille; Fleurat-Lessard, Paul; Soule, Jean-Francois; Doucet, Henri published an article in Chemistry – A European Journal. The article was 《C-H Bond Arylation of Pyrazoles at the β-Position: General Conditions and Computational Elucidation for a High Regioselectivity》. The article mentions the following:

Direct arylation of most five-membered ring heterocycles are generally easily accessible and strongly favored at the α-position using classical palladium-catalysis. Conversely, regioselective functionalization of such heterocycles at the concurrent β-position remains currently very challenging. Herein, authors report general conditions for regioselective direct arylation at the β-position of pyrazoles, while C-H α-position is free. By using aryl bromides as the aryl source and a judicious choice of solvent, the arylation reaction of variously N-substituted pyrazoles simply proceeds via β-C-H bond functionalization. The β-regioselectivity is promoted by a ligand-free palladium catalyst and a simple base without oxidant or further additive, and tolerates a variety of substituents on the bromoarene. DFT calculations revealed that a protic solvent such as 2-ethoxyethan-1-ol significantly enhances the acidity of the proton at β-position of the pyrazoles and thus favors this direct β-C-H bond arylation. This selective pyrazoles β-C-H bond arylation was successfully applied for the straightforward building of π-extended poly(hetero)aromatic structures via further Pd-catalyzed combined α-C-H intermol. and intramol. C-H bond arylation in an overall highly atom-economical process. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Quality Control of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Quality Control of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1-MethylpyrazoleOn June 9, 2022, Rong, Deqin; Zhou, Kaixin; Fang, Wei; Yang, Hong; Zhang, Yi; Shi, Qiongyu; Huang, Yuting; Li, Jiayi; Dong, Hui; Li, Lanlan; Ding, Jian; Huang, Xun; Wang, Yuanxiang published an article in Journal of Medicinal Chemistry. The article was 《Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5》. The article mentions the following:

PRMT5 is a major type II protein arginine methyltransferase and plays important roles in diverse cellular processes. Overexpression of PRMT5 is implicated in various types of cancer. Many efforts have been made to develop potent and selective PRMT5 inhibitors, the most potent of which is usually derived from nucleoside structures. Here, we designed a novel series of non-nucleoside PRMT5 inhibitors through the structure-aided drug design approach. SAR exploration and metabolic stability optimization led to the discovery of compound 41 as a potent PRMT5 inhibitor with good selectivity. Addnl., compound 41 exerted antiproliferative effects against A375 cells by inducing apoptosis and potently inhibited the methyltransferase activity of PRMT5 in cells. Moreover, it showed attractive pharmacokinetic properties and markedly suppressed the tumor growth in an A375 tumor xenograft model. These results clearly indicate that 41 is a highly potent and selective non-nucleoside PRMT5 inhibitor. The experimental process involved the reaction of 1-Methylpyrazole(cas: 930-36-9Application In Synthesis of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application In Synthesis of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 930-36-9On November 1, 2019 ,《Hydroxyl-functionalized pyrazolium ionic liquids to catalyze chemical fixation of CO2: Further benign reaction condition for the single-component catalyst》 appeared in Journal of Molecular Liquids. The author of the article were Wang, Tengfei; Ma, Yuan; Jiang, Jiamin; Zhu, Xinrui; Fan, Baowan; Yu, Guanyao; Li, Ningning; Wang, Shasha; Ren, Tiegang; Wang, Li; Zhang, Jinglai. The article conveys some information:

Lots of ionic liquids have been utilized as catalyst for the coupling reaction of carbon dioxide with epoxides; however, catalyzed conditions could not be regarded as benign, especially when no co-catalyst and/or organic solvent is involved. A series of hydroxyl-functionalized pyrazolium ionic liquids are firstly synthesized. They would efficiently catalyze the cycloaddition of carbon dioxide and propylene oxide under 110°C and 1.0 MPa carbon dioxide initial pressure with 1 mol% catalyst during 4 h resulting in the product yield of 91.2%. The catalytic condition is greatly refined as compared with other single-component ionic liquids with simple anion. Simultaneously, the effect of reaction temperature, amount of catalyst, carbon dioxide initial pressure, and reaction time is explored along with the reusability of catalyst. For most of epoxides with terminal substituted group, HEEPzBr presents acceptable catalytic activity. The difference of HEMPzBr, HEEPzBr, and HPEPzBr is also explored by the d. functional theory calculations The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Recommanded Product: 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Recommanded Product: 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2020,Catalysis Science & Technology included an article by Zhang, Shaoke; Weniger, Florian; Kreyenschulte, Carsten Robert; Lund, Henrik; Bartling, Stephan; Neumann, Helfried; Ellinger, Stefan; Taeschler, Christoph; Beller, Matthias. COA of Formula: C4H6N2. The article was titled 《Towards a practical perfluoroalkylation of (hetero)arenes with perfluoroalkyl bromides using cobalt nanocatalysts》. The information in the text is summarized as follows:

A convenient methodol. for perfluoroalkylation including trifluoromethylation of (hetero)arenes with perfluoroalkyl bromides was developed. Key for the success is the use of a specific cobalt-based nanocatalyst, which can be recycled at least up to 4 times. The scope of this first cobalt-catalyzed perfluoroalkylation is presented. In addition to this study using 1-Methylpyrazole, there are many other studies that have used 1-Methylpyrazole(cas: 930-36-9COA of Formula: C4H6N2) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. COA of Formula: C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Quality Control of 1-MethylpyrazoleOn October 10, 2020 ,《Measurement and correlation of solubility of 1-methyl-3,4,5-trinitropyrazole in twelve pure solvents at temperatures from 283.15 K to 323.15 K》 was published in Journal of Molecular Liquids. The article was written by Zhang, Tong-wei; Guo, Hao-qi; Li, Yong-xiang; Liu, Yong-zheng. The article contains the following contents:

In the present study, the solubility of 1-methyl-3,4,5-trinitropyrazole (MTNP) was determined by a dynamic laser monitoring at T = (283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, 318.15 and 323.15) K in twelve pure solvents, including water, benzene (Ph), di-Me sulfate (DMS), methylbenzene (PhMe), THF (THF), methanol (MeOH), ethanol (EtOH), 1,2-dichloroethane (DCE), nitromethane (NM), acetonitrile (ACN), Et acetate (EA) and formic acid (FA), at atm. pressure (P = 0.1 MPa). In the temperature range from 283.15 K to 323.15 K, the mole fraction solubility values of MTNP in water, Ph, DMS, PhMe, THF, MeOH, EtOH, DCE, NM, ACN, EA and FA were 0.000008-0.000072, 0.003495-0.025271, 0.002153-0.037197, 0.001602-0.012304, 0.002103-0.074525, 0.000318-0.001625, 0.003752-0.048205, 0.017836-0.047105, 0.008408-0.016783, 0.003579-0.012367, 0.004460-0.022006 and 0.220917-0.443206. As revealed from the exptl. results, the solubility of MTNP in twelve pure solvents increased with the increase in the temperature The solubility behaviors of MTNP in investigated solvents were analyzed with the Hansen solubility parameter. The Kamlet-Taft parameters were calculated to delve into the solvent effect. Subsequently, the measured solubility data was correlated with five thermodn. models, i.e., the modified Apelblat equation, λh equation, NRTL model, Wilson model and Two-Suffix Margules model. Overall, the NRTL model provided the most satisfactory fitting results. As revealed from the results, the min. average values of relative mean deviation (104ARD) and root-mean square deviation (104RMSD) were determined with the NRTL model that achieved the values of 2.06 and 1.49. Furthermore, the dissolution thermodn. parameters, including mixing enthalpy (ΔmixH), mixing entropy (ΔmixS) and mixing Gibbs energy (ΔmixG) were calculated according to the Wilson model, and the relative contributions of enthalpy %ζH and entropy %ζS were also calculated It can be seen that the dissolution of MTNP in a given solvent is spontaneous and entropy driven. In the experiment, the researchers used 1-Methylpyrazole(cas: 930-36-9Quality Control of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Quality Control of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Jagtap, Ajit Dhananjay; Kondekar, Nagendra B.; Hung, Pei-Yun; Hsieh, Chen-En; Yang, Chia-Ron; Chen, Grace Shiahuy; Chern, Ji-Wang published an article on January 31 ,2020. The article was titled 《4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1》, and you may find the article in Bioorganic Chemistry.Product Details of 930-36-9 The information in the text is summarized as follows:

Herein, the authors report the identification, design, and synthesis of a series of 4-substituted 2-amino-3,4-dihydroquinazolines I [R1 = Me, CH:CH2, Bn, etc., R2 = Me, cyclopropyl, (1-methyl-1H-pyrazol-4-yl)methyl] with hairpin turn side chains as novel inhibitors of BACE-1. The dihydroquinazoline derivatives were rationally designed by modifying the amide group and relocating the α-hydrophobic substituent on the hairpin turn side chain of lead compound II to the C4-position on the 3,4-dihydroquinazoline scaffold to facilitate interactions with the S1, S2 and S1′ subsites of BACE-1. Among these derivatives, two compounds exhibited potent BACE-1 inhibitory activity: 4-methyl-substituted derivative I [R1 = Me, R2 = (1-methyl-1H-pyrazol-4-yl)methyl] (BACE-1 CFA IC50 = 0.38μM; BACE-1 WCA IC50 = 0.14μM) and 4-cyclohexylmethyl-substituted derivative I [R1 = cyclohexylmethyl, R2 = (1-methyl-1H-pyrazol-4-yl)methyl] (BACE-1 CFA IC50 = 0.49μM; BACE-1 WCA IC50 = 0.14μM). The results suggest that the structural modifications maintain the hairpin turn topol. similar to that of compound II and provide an addnl. interaction with the S2 subsite. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Product Details of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Sun, Xiaohua; Feng, Lijun; Sun, Chuance; Kang, Congmin published their research in Pharmaceutical Chemistry Journal on December 31 ,2021. The article was titled 《Synthesis of Quinoxaline Derivatives as Intermediates to Obtain Erdafitinib》.Related Products of 930-36-9 The article contains the following contents:

In this work, quinoxaline derivative 7-bromo-2-(1-methyl-1H-pyrazol-4-yl)quinoxaline, which is an essential intermediate to obtain drug erdafitinib, has been synthesized in reasonably good yield using 4-bromobenzene-1,2-diamine and 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)ethan-1-one as raw materials, triethylene diamine (DABCO) as catalyst, and THF as solvent. To the best of authors’ knowledge, this is the first time 7-bromo-2-(1-methyl-1H-pyrazol-4-yl)quinoxaline has been acquired by the proposed method. In the experiment, the researchers used 1-Methylpyrazole(cas: 930-36-9Related Products of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics