Category: 930-36-9

《Direct electrochemical hydrodefluorination of trifluoromethyl ketones enabled by non-protic conditions》 was published in Chemical Science in 2021. These research results belong to Box, John R.; Atkins, Alexander P.; Lennox, Alastair J. J.. Name: 1-Methylpyrazole The article mentions the following:

CF2H groups are unique due to the combination of their lipophilic and hydrogen bonding properties. The strength of H-bonding is determined by the group to which it is appended. Several functional groups have been explored in this context including O, S, SO and SO2 to tune the intermol. interaction. Difluoromethyl ketones are under-studied in this context, without a broadly accessible method for their preparation Herein, authors describe the development of an electrochem. hydrodefluorination of readily accessible trifluoromethyl ketones. The single-step reaction at deeply reductive potentials is uniquely amenable to challenging electron-rich substrates and reductively sensitive functionality. Key to this success is the use of non-protic conditions enabled by an ammonium salt that serves as a reductively stable, masked proton source. Anal. of their H-bonding has revealed difluoromethyl ketones to be potentially highly useful dual H-bond donor/acceptor moieties. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Name: 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Name: 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Britton, Luke; Skrodzki, Maciej; Nichol, Gary S.; Dominey, Andrew P.; Pawluc, Piotr; Docherty, Jamie H.; Thomas, Stephen P. published an article in ACS Catalysis. The title of the article was 《Manganese-Catalyzed C(sp2)-H Borylation of Furan and Thiophene Derivatives》.Quality Control of 1-Methylpyrazole The author mentioned the following in the article:

Aryl boronic esters are bench-stable, platform building-blocks that can be accessed through metal-catalyzed aryl C(sp2)-H borylation reactions. C(sp2)-H bond functionalization reactions using rare- and precious-metal catalysts are well established, and while examples using Earth-abundant alternatives have emerged, Mn catalysis remains lacking. The Mn-catalyzed C-H borylation of furan and thiophene derivatives is reported alongside an in situ activation method providing facile access to the active Mn hydride species. Mechanistic studies showed that blue light irradiation directly affected catalysis by action at the metal center, that C(sp2)-H bond borylation occurs through a C-H metalation pathway, and that the reversible coordination of pinacolborane to the catalyst gave a Mn borohydride complex, which was as an off-cycle resting state. The results came from multiple reactions, including the reaction of 1-Methylpyrazole(cas: 930-36-9Quality Control of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Quality Control of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Category: pyrazoles-derivativesOn October 16, 2020 ,《Stereodivergent Synthesis of Alkenylpyridines via Pd/Cu Catalyzed C-H Alkenylation of Pyridinium Salts with Alkynes》 was published in Organic Letters. The article was written by Li, Wenjing; Tang, Juan; Li, Shun; Zheng, Xueli; Yuan, Maolin; Xu, Bin; Jiang, Weidong; Haiyan Fu; Li, Ruixiang; Chen, Hua. The article contains the following contents:

The first Pd/Cu catalyzed selective C2-alkenylation of pyridines with internal alkynes has been developed via the pyridinium salt activation strategy. Importantly, the configuration of the product alkenylpyridines could be tuned by the choice of the proper N-alkyl group of the pyridinium salts, thus allowing for both the Z- and E-alkenylpyridines synthesized with good regio- and stereoselectivity. A plausible mechanism was proposed based on the Hammett study and KIE experiment In addition to this study using 1-Methylpyrazole, there are many other studies that have used 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Highly active hybrid mesoporous silica-supported base organocatalysts for C-C bond formation》 was written by Erigoni, A.; Hernandez-Soto, M. C.; Rey, F.; Segarra, C.; Diaz, U.. Recommanded Product: 930-36-9 And the article was included in Catalysis Today on April 1 ,2020. The article conveys some information:

New base hybrid catalysts, based on silyl-derivatives of mols. carrying amino, diamino, pyrrolidine, pyrazolium and imidazolium functionalities were successfully achieved through post synthetic grafting onto M41S-type support. Different characterization techniques were implemented to study the characteristics of the materials, such as elemental anal., solid state MAS NMR and FTIR spectroscopies, X-ray diffraction (XRD), thermogravimetric and differential thermal analyses (TGA-DTA) and textural properties through N2 physisorption anal. The catalytic activity and recyclability of these compounds as base catalysts was demonstrated for C-C bond forming reactions such as Knoevenagel condensations and Michael additions rationalizing the differences observed as function of the reaction mechanisms. An enamine mechanism was proposed for Knoevenagel condensations and an enolate mechanism for Michael additions The experimental process involved the reaction of 1-Methylpyrazole(cas: 930-36-9Recommanded Product: 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Li, Guangbin; Field, James A.; Zeng, Chao; Madeira, Camila Leite; Nguyen, Chi Huynh; Jog, Kalyani Vikas; Speed, David; Sierra-Alvarez, Reyes published their research in Chemosphere on February 29 ,2020. The article was titled 《Diazole and triazole inhibition of nitrification process in return activated sludge》.Category: pyrazoles-derivatives The article contains the following contents:

Azoles are emerging contaminants that are resistant to biodegradation during wastewater treatment. Their presence has been widely reported in wastewater effluents and receiving waters. In this work, the potential inhibition of nitrification process by six different azole compounds in wastewater treatment plants was investigated in batch bioassays. The azoles studied included three diazoles: pyrazole (Pz); 1-methylpyrazole (MePz); 3,5-dimethylpyrazole (DMePz); and three triazoles: 1,2,4-triazole (Tz); benzotriazole (BTz); and 5-Me benzotriazole (MeBTz). The concentration of azoles causing 50% inhibition (IC50) increased (azoles became less inhibitory) in the following order (mg L-1): BTz (1.99) < MeBTz (2.18) < Pz (2.69) < Tz (3.53) < DMePz (17.3) < MePz (49.6). No clear structure-inhibitory relationships were found using Log P and pKa as structural properties. The toxicity of any given azole may be related to the role of substituent groups on disabling/enabling binding to the active sites of metallo-enzymes in nitrifying microorganisms. This is exemplified by the low toxicity of MePz, which has a cyclic N blocked by a Me group. The observed inhibition caused to nitrifying bacteria is more severe than their cytotoxicity to other target organisms (e.g., methanogens and heterotrophic bacteria), suggesting a specific inhibition to the copper-containing enzyme, ammonium monooxygenase, in ammonia oxidizing nitrifying microorganisms. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Structure-antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety》 was published in RSC Advances in 2022. These research results belong to Ohta, Kaito; Fushimi, Tetsuya; Okamura, Mutsumi; Akatsuka, Akinobu; Dan, Shingo; Iwasaki, Hiroki; Yamashita, Masayuki; Kojima, Naoto. Electric Literature of C4H6N2 The article mentions the following:

We studied hybrid mols. of annonaceous acetogenins and mitochondrial complex I-inhibiting insecticides to develop a novel anticancer agent. A structure-antitumor activity relationship study focusing on the connecting groups between the heterocycles and the linker moiety bearing the THF moiety was conducted. Eleven hybrid acetogenins with 1-methylpyrazole instead of γ-lactone were synthesized and their growth inhibitory activities against 39 human cancer cell lines were evaluated. The nitrogen atom at the 2′-position of the linker moiety was essential for inhibiting cancer growth. The 1-methylpyrazole-5-sulfonamide analog showed potent growth inhibition of NCI-H23, a human lung cancer cell line, in a xenograft mouse assay without critical toxicity. Hence, the results of this study may pave the way for the development of novel anticancer agents, with both selective and broad anticancer activities. In the experiment, the researchers used 1-Methylpyrazole(cas: 930-36-9Electric Literature of C4H6N2)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Electric Literature of C4H6N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Gas Chromatography-Mass Spectrometry Quantification of 1,1-Dimethylhydrazine Transformation Products in Aqueous Solutions: Accelerated Water Sample Preparation》 was published in Molecules in 2021. These research results belong to Popov, Mark S.; Ul’yanovskii, Nikolay V.; Kosyakov, Dmitry S.. Safety of 1-Methylpyrazole The article mentions the following:

The use of highly toxic rocket fuel based on 1,1-dimethylhydrazine (UDMH) in many types of carrier rockets poses a threat to environment and human health associated with an ingress of UDMH into wastewater and natural reservoirs and its transformation with the formation of numerous toxic nitrogen-containing products. Their GC-MS quantification in aqueous samples requires matrix change and is challenging due to high polarity of analytes. To overcome this problem, accelerated water sample preparation (AWASP) based on the complete removal of water with anhydrous sodium sulfate and transferring analytes into dichloromethane was used. Twenty-nine UDMH transformation products including both the acyclic and heterocyclic compounds of various classes were chosen as target analytes. AWASP ensured attaining near quant. extraction of 23 compounds with sample preparation procedure duration of no more than 5 min. Combination of AWASP with gas chromatog.-mass spectrometry and using pyridine-d5 as an internal standard allowed for developing the rapid, simple, and low-cost method for simultaneous quantification of UDMH transformation products with detection limits of 1-5 μg L-1 and linear concentration range covering 4 orders of magnitude. The method has been validated and successfully tested in the anal. of aqueous solutions of rocket fuel subjected to oxidation with atm. oxygen, as well as pyrolytic gasification in supercritical water modeling wastewater from carrier rockets launch sites. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Safety of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Safety of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 930-36-9On May 31, 2019, Doba, Takahiro; Matsubara, Tatsuaki; Ilies, Laurean; Shang, Rui; Nakamura, Eiichi published an article in Nature Catalysis. The article was 《Homocoupling-free iron-catalyzed twofold C-H activation/cross-couplings of aromatics via transient connection of reactants》. The article mentions the following:

Herein, an efficient strategy was developed for the synthesis of biaryls and (aryl)alkenamides Ar(R)C=C(R1)C(O)NHAr1 [R = Me; R1 = Me; RR1 = (CH2)4; Ar = 3,4-Cl2C6H3, 5-Ph-2-thienyl, benzothiophen-2-yl, etc.; Ar1 = 8-quinolyl] via iron-catalyzed twofold C-H activation/cross-coupling of arenes with alkenyl/aryl carboxamides. A transient connection of two reactants by an anionic group appended to one reactant helped to achieve this goal under mildly oxidative iron-catalyzed conditions, through the formation of a productive heteroleptic R1-M-R2 intermediate. An N-(quinolin-8-yl)amide anion was utilized for the temporary connection and cross-coupled a stoichiometric mixture of aromatics in high yield without any trace of homocoupling products. A short-step synthesis of several donor/acceptor thiophene compounds and carbon/sulfur-bridged flat conjugated systems illustrated the utility of this method to streamline organic synthesis. After reading the article, we found that the author used 1-Methylpyrazole(cas: 930-36-9Application of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Palladium-catalyzed polyannulation of pyrazoles and diynes toward multifunctional poly(indazole)s under monomer non-stoichiometric conditions》 was published in Polymer Chemistry in 2019. These research results belong to Gao, Qingqing; Han, Ting; Qiu, Zijie; Zhang, Ruoyao; Zhang, Jun; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Tang, Ben Zhong. Category: pyrazoles-derivatives The article mentions the following:

A new synthetic route toward multifunctional poly(indazole)s (PIs) with an effect of monomer stoichiometry imbalance-promoted polymerization is described in this work. The palladium-catalyzed oxidative polyannulations of internal diynes and 1-methylpyrazole proceed smoothly in 1,4-dioxane at 120°C with copper acetate monohydrate functioning as the oxidant. A series of PIs with high mol. weights (Mw up to 35 800) are generated in good yields (up to 84.0%) under monomer non-stoichiometric conditions. These polymers exhibit high thermal stability, losing merely 5% of their weights at high temperatures of 321-353°C. The solid thin films of these PIs show high and UV-tunable refractive indexes (n = 1.8870-1.6051) in a wide wavelength range of 400-900 nm. The tetraphenylethene-containing PI shows obvious solid-state emission properties and good photosensitivity. Its thin film was successfully fabricated into a well-defined two-dimensional fluorescent photopattern with sharp edges. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 930-36-9On May 3, 2021 ,《Electrophotocatalytic C-H Azolation of Arenes》 appeared in ChemElectroChem. The author of the article were Hou, Zhong-Wei; Xu, Hai-Chao. The article conveys some information:

An electrophotocatalytic method was developed for the dehydrogenative cross coupling of arenes with azoles employing a bicatalytic system consisting of acridinium dye and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). The reactions were conducted in a simple undivided cell with visible-light irradiation and requires no external chem. oxidant. In addition to this study using 1-Methylpyrazole, there are many other studies that have used 1-Methylpyrazole(cas: 930-36-9Product Details of 930-36-9) was used in this study.

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics