Category: 52867-42-2

Analyzing the synthesis route of 52867-42-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, its application will become more common.

Reference of 52867-42-2,Some common heterocyclic compound, 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 25-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (tetrahydro-pyran-4-yl)-amide a) Methyl 5-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylate; To a solution of [5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-methanol (290 mg, 1.4 mmol) in THF (30 mL) was added 5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (218 mg, 1.4 mmol) and triphenylphosphine (477 mg, 1.82 mmol) at ambient temperature under an argon atmosphere. Then diethyl azodicarboxylate (641 muL, 3.5 mmol) was added and the reaction mixture was stirred for 16 h at room temperature. Concentration and purification by chromatography (silica, 20 to 50% ethyl acetate in heptane) afforded the title compound (483 mg, 100%) as a white solid. MS: m/e=346.2 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, its application will become more common.

Continuously updated synthesis method about 52867-42-2

The synthetic route of 52867-42-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H8N2O3

To a stirred solution of methyl 5-hydroxy-2-methyl-pyrazole-3-carboxylate (0.3 g, 1.92mmol) in DCM (30 mL) at 0 C, Pyridine (0.18 g, 2.30 mmol) followed by Tf20 (0.59 g, 2.11mmol) was added dropwise. The reaction mixture was slowly warmed toRT and stirred for 2h (TLC indicated complete consumption of starting material). The reaction mixture wasslowly diluted with water (15 mL) and extracted with DCM (2 x 30 mL). The combinedorganic extracts were washed with brine (25 mL), dried over Na2S04 and concentrated underreduced pressure to afford methyl 2-methyl-5-(trifluoromethylsulfonyloxy)pyrazole-3-carboxylate (580 mg, 93% ), which was carried to the next step without further purification.LCMS: m/z: 289.4 [M+Ht.

The synthetic route of 52867-42-2 has been constantly updated, and we look forward to future research findings.

Extended knowledge of Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

52867-42-2, A common compound: 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

In a three-necked round bottom flask were successively added acetone 20mL, methyl 3-hydroxy-1-methylpyrazole-5-carboxylate 5mmol, 1,1,3_ trichloropropene 5.5mmol alkaline conditions at room temperature for 12h, filtered , Acetone, and concentrated to give methyl 3- (3,3-dichloroallyloxy) -1-methylpyrazole-5-carboxylate as a white solid in 95% yield, purity 95%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Extended knowledge of Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

52867-42-2, A common compound: 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

In a three-necked round bottom flask were successively added acetone 20mL, methyl 3-hydroxy-1-methylpyrazole-5-carboxylate 5mmol, 1,1,3_ trichloropropene 5.5mmol alkaline conditions at room temperature for 12h, filtered , Acetone, and concentrated to give methyl 3- (3,3-dichloroallyloxy) -1-methylpyrazole-5-carboxylate as a white solid in 95% yield, purity 95%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.