20154-03-4 | Page 4 of 14 | pyrazoles-derivatives

Lv, Shuaipeng’s team published research in Communications Chemistry in 2019 | CAS: 20154-03-4

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Category: pyrazoles-derivatives

《Lewis base-catalyzed intermolecular triazene alkyne cycloaddition for late-stage functionalization and scaffold diversification》 was written by Lv, Shuaipeng; Zhou, Hui; Yu, Xin; Xu, Yue; Zhu, Huijuan; Wang, Min; Liu, Haitao; Dai, Ziru; Sun, Guibo; Gong, Xiaojie; Sun, Xiaobo; Wang, Lei. Category: pyrazoles-derivativesThis research focused ontriazene 3 Trifluoromethylpyrazole cycloaddition Lewis base platelet aggregation inhibitor. The article conveys some information:

3-Trifluoromethylpyrazole and its derivatives are of major interest to both the agrochem. and pharmaceutical industry for their diverse biol. activities. Reported routes for the synthesis of 3-trifluoromethylpyrazoles are hindered by poor regioselectivity and limited scope of application. Here we report a directed Lewis base catalyzed intermol. triazene-alkyne cycloaddition It is featured that the combination of 1,8-diazabicyclo[5.4.0]undec-7-ene and 2,2,2-trifluorodiazoethane produces reactive triazene intermediates, which readily participate in cycloaddition reactions with terminal/internal alkynes, thus assembling densely substituted 3-trifluoromethylpyrazole scaffolds with environmental friendliness and operational simplicity. Synthetic utility of the protocol is highlighted by late-stage functionalization and scaffolds diversification. The practical value is also emphasized in potential platelet aggregation inhibitor synthesis. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Category: pyrazoles-derivatives) was used in this study.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Greenacre, Victoria K.’s team published research in Organometallics in 2015 | CAS: 20154-03-4

Formula: C4H3F3N2In 2015 ,《Ruthenaphosphaalkenyls: synthesis, structures, and their conversion to η2-phosphaalkene complexes》 was published in Organometallics. The article was written by Greenacre, Victoria K.; Trathen, Nicola; Crossley, Ian R.. The article contains the following contents:

The ruthenaphosphaalkenyls [Ru{P:CH(SiMe2R)}Cl(CO)(PPh3)2] (R = Me, Ph, Tol) have been prepared in good yield by the facile hydroruthenation of the resp. phosphaalkynes, RMe2SiCP, with [RuHCl(CO)(PPh3)3]; all three compounds have been structurally characterized in the solid state. Complemented by DFT studies of these, and the precedent [Ru{P:CH(tBu)}Cl(CO)(PPh3)2], the phosphaalkenyl moieties have been established unequivocally to behave as one-electron donors to the coordinately unsaturated, 15-electron “”RuCl(CO)(PPh3)2″” fragment, corroborating an earlier demonstration of nucleophilic character at phosphorus within the tert-Bu system. Notwithstanding, the ruthenaphosphaalkenyls are shown to react with the nucleophiles Lipz’ (pz’ = pz, pz*, pzH,CF3, pzMe,CF3) to afford the η1,η2-chelated pyrazolylphosphaalkene complexes [Ru{η1-N:η2-P,C-P(pz’):CH(R)}(CO)(PPh3)2], which feature a three-membered metallacyclic (Ru-C-P) core. The nature of these novel compounds is discussed, alongside preliminary insight into the process by which they are formed. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Formula: C4H3F3N2)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Gaulier, Steven M.’s team published research in Tetrahedron Letters in 2012 | CAS: 20154-03-4

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Category: pyrazoles-derivatives

In 2012,Gaulier, Steven M.; McKay, Reuben; Swain, Nigel A. published 《A novel three-step synthesis of celecoxib via palladium-catalyzed direct arylation [Erratum to document cited in CA155:562830]》.Tetrahedron Letters published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:

On page 6001, Compound 4 in Scheme 1 contained a structure error; the corrected scheme is given. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Category: pyrazoles-derivatives)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kabir, M. Shahjahan’s team published research in Organic Letters in 2010 | CAS: 20154-03-4

Safety of 3-(Trifluoromethyl)-1H-pyrazoleIn 2010 ,《First Application of an Efficient and Versatile Ligand for Copper-Catalyzed Cross-Coupling Reactions of Vinyl Halides with N-Heterocycles and Phenols》 appeared in Organic Letters. The author of the article were Kabir, M. Shahjahan; Lorenz, Michael; Namjoshi, Ojas A.; Cook, James M.. The article conveys some information:

2-Pyridin-2-yl-1H-benzoimidazole (I) is presented as a new, efficient, and versatile bidentate N-donor ligand suitable for the copper-catalyzed formation of vinyl C-N and C-O bonds. This inexpensive and easily prepared ligand facilitates copper-catalyzed cross-coupling reactions of alkenyl bromides and iodides with N-heterocycles and phenols to afford the desired cross-coupled products in good to excellent yields with full retention of stereochem. This method is particularly noteworthy given its efficiency, i.e., mild reaction conditions, low catalyst loading, simplicity, versatility, and exceptional level of functional group tolerance. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Safety of 3-(Trifluoromethyl)-1H-pyrazole)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ma, Hong-Ju’s team published research in Pest Management Science in 2015 | CAS: 20154-03-4

Recommanded Product: 20154-03-4In 2015 ,《Design, synthesis and herbicidal evaluation of novel 4-(1H-pyrazol-1-yl)pyrimidine derivatives》 appeared in Pest Management Science. The author of the article were Ma, Hong-Ju; Zhang, Jian-Hua; Xia, Xiang-Dong; Kang, Jing; Li, Jian-Hong. The article conveys some information:

A series of novel pyrazolylpyrimidine derivatives I (R1 = H, CH3; R2 = OCH2CH3, SCH3, SO2CH3, N(CH3)2, etc.; R3 = H, CH3; R4 = CF3; X = H, Cl) were designed and synthesized. The herbicidal activities of 30 pyrazolylpyrimidine derivatives were assessed. Nine compounds caused good herbicidal activity for Pennisetum alopecuroides L. Among them, I (R1 = H; R2 = NHCH2CH3; R3 = CH3; R4 = CF3; X = H) exhibited the strongest inhibitory activity against the root growth of P. alopecuroides, with an IC50 of 1.90 mg L-1. Compound I (R1 = CH3; R2 = prop-2-yn-1-yloxy; R3 = CH3; R4 = CF3; X = H) produced the highest inhibition of chlorophyll level in seedlings of P. alopecuroides (IC50 = 3.14 mg L-1). The structure-activity relationship indicated that the alkynyloxy group at the 6-position on the pyrimidine ring played a very important role for bleaching activities. When the alkynyloxy group was replaced by alkoxy, amino, alkylthio and alkylsulfonyl groups, the bleaching activities of the compounds were diminished. However, the compounds substituted by an amino at the 6-position of the pyrimidine ring exhibited excellent inhibition activities against weed root growth. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 20154-03-4) was used in this study.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ahmed, Basil M.’s team published research in Dalton Transactions in 2016 | CAS: 20154-03-4

In 2016,Ahmed, Basil M.; Calco, Brice; Mezei, Gellert published 《Tuning the structure and solubility of nanojars by peripheral ligand substitution, leading to unprecedented liquid-liquid extraction of the carbonate ion from water into aliphatic solvents》.Dalton Transactions published the findings.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

Nanojars, a novel class of neutral anion-incarcerating agents [CuII(OH)(pz)]n (Cun; n = 27-31, pz = pyrazolate anion), efficiently sequester various oxoanions with large hydration energies from H2O. The authors explore whether substituents on the pyrazole ligand interfere with nanojar formation, and whether appropriate substituents could be employed to tune the solubility of nanojars in solvents of interest, such as long-chain aliphatic hydrocarbons (solvent of choice for large-scale liquid-liquid extraction processes) and H2O. To this end, the authors conducted a comprehensive study using 40 different pyrazole ligands, with one, two or three substituents in their 3-, 4- and 5-positions. The corresponding nanojars were characterized by single-crystal x-ray diffraction and/or electrospray-ionization mass spectrometry (ESI-MS). Cun-nanojars with various substituents in the pyrazole 4-position, including long chains, Ph and CF3 groups, can be obtained. Straight chains are also tolerated at the pyrazole 3-position, and favor the Cu30-nanojar. Homoleptic nanojars, however, could not be obtained with Ph or CF3 groups. Nevertheless, if used in mixture with the parent nonsubstituted pyrazole, sterically hindered pyrazoles do form heteroleptic nanojars. With 3,5-disubstituted pyrazoles, only heteroleptic nanojars are accessible. The crystal structure of novel nanojars (Bu4N)2[CO3⊂{Cu30(OH)30(3,5-Me2pz)y(pz)30-y}] (y = 14 and 15) is presented. In contrast to the parent nanojar, which is insoluble in aliphatic solvents and H2O, nanojars with alkyl substituents are soluble in saturated hydrocarbon solvents, whereas nanojars based on novel pyrazoles, functionalized with oligoether chains, are readily soluble in H2O. Liquid-liquid extraction of carbonate from H2O under basic pH is presented for the first time. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Quality Control of 3-(Trifluoromethyl)-1H-pyrazole)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ma, Hong-Ju’s team published research in Pest Management Science in 2014 | CAS: 20154-03-4

In 2014,Ma, Hong-Ju; Zhang, Jian-Hua; Xia, Xiang-Dong; Xu, Meng-Han; Ning, Jun; Li, Jian-Hong published 《Design, synthesis and herbicidal activities of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives as potential pigment biosynthesis inhibitors》.Pest Management Science published the findings.Synthetic Route of C4H3F3N2 The information in the text is summarized as follows:

BACKGROUND With the objective of finding novel valuable herbicidal candidates, a series of novel 4-(1H-pyrazol-1-yl)-6-(alkynyloxy)-pyrimidine derivatives were synthesized and their herbicide activities were evaluated in vivo. RESULTS The results showed that many target compounds expressed bleaching activities. Among these, compound 5 h showed the best bleaching activity to gramineous weeds, being able to produce the highest inhibition of chlorophyll level in seedlings of Pennisetum alopecuroides L. (IC50 = 3.48 mg L-1). Moreover, compound 5 h expressed good selective toxicity between gramineous P. alopecuroides L. and broadleaf plant Brassica campestris L. CONCLUSIONS The present work demonstrates that pyrimidine derivatives containing pyrazole can be used as potential lead compounds for developing novel pigment biosynthesis inhibitors. © 2013 Society of Chem. Industry. In the experimental materials used by the author, we found 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Synthetic Route of C4H3F3N2)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Chen, Xu-Lin’s team published research in Chemistry of Materials in 2013 | CAS: 20154-03-4

In 2013,Chen, Xu-Lin; Yu, Rongmin; Zhang, Qi-Kai; Zhou, Liu-Jiang; Wu, Xiao-Yuan; Zhang, Qing; Lu, Can-Zhong published 《Rational Design of Strongly Blue-Emitting Cuprous Complexes with Thermally Activated Delayed Fluorescence and Application in Solution-Processed OLEDs》.Chemistry of Materials published the findings.Recommanded Product: 20154-03-4 The information in the text is summarized as follows:

Strongly greenish-blue to blue emitting Cu-(NN)(POP)+ (POP = bis[2-(diphenylphosphino)phenyl] ether) complexes containing N-linked 2-pyridylpyrazolate diimine ligands [Cu(pypz)(POP)]BF4 (1), [Cu(pympz)(POP)]BF4 (2), and [Cu(pytfmpz)(POP)]BF4 (3) (pypz = 1-(2-pyridyl)pyrazole, pympz = 3-Me-1-(2-pyridyl)pyrazole, and pytfmpz = 3-trifluoromethyl-1-(2-pyridyl)pyrazole) were designed and synthesized. Their structural, electrochem., and photophys. properties were characterized. The complexes 1-3 exhibit high luminescence quantum yields (PLQYs) at room temperature both in N-saturated CH2Cl2 (≤45%) and in neat solid (≤87%), which are comparable to the reported highest values for the cuprous complexes. The temperature dependence of spectroscopic properties and emission decay behaviors reveal 2 thermally equilibrated emitting states. At temperatures <150 K, the lowest triplet state (T1) is the predominant emitting state resulting in the typical phosphorescence with the emission decay times in the order of hundreds of μs. At ambient temperature, the lowest singlet state (S1), which lies only ∼0.17-0.18 eV above the T1 state, is populated thermally and in turn generates efficient thermally activated delayed fluorescence (TADF), and the emission decay times are reduced dramatically to, e.g., 12.2 μs for 2. Solution-processed OLEDs containing 1-3 in the emissive layer demonstrated excellent device performances by taking advantage of the singlet harvesting mechanism, among which the electroluminescent device using 3 shows a peak external quantum efficiency (EQE) of 8.47%, a peak current efficiency (CE) of 23.68 cd/A, and a maximum brightness of 2033 cd/m2. Crystallog. data are given. The experimental process involved the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 20154-03-4)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Al Mousawi, Assi’s team published research in Polymer Chemistry in 2017 | CAS: 20154-03-4

In 2017,Al Mousawi, Assi; Kermagoret, Anthony; Versace, Davy-Louis; Toufaily, Joumana; Hamieh, Tayssir; Graff, Bernadette; Dumur, Frederic; Gigmes, Didier; Fouassier, Jean Pierre; Lalevee, Jacques published 《Copper photoredox catalysts for polymerization upon near UV or visible light: structure/reactivity/efficiency relationships and use in LED projector 3D printing resins》.Polymer Chemistry published the findings.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

Copper complexes (CuCs) bearing pyridine-pyrazole ligands are synthesized and evaluated as new photocatalysts/photoinitiators in combination with an iodonium salt (Iod) for the free radical polymerization of (meth)acrylates and the cationic polymerization of epoxides upon visible light exposure using Light Emitting Diode (LED)@405nm. The structure/reactivity/efficiency relationships for the copper complexes are studied as well as the chem. mechanisms involved. The different substituents on the pyrazole moiety of the ligand allow to tune the oxidation potential and the visible light absorbance of the complexes and to optimize the performance of the polymerization photocatalysts. The use of a novel additive (CARET) in a three-component system (CuC/Iod/CARET) highly improves the performance. Finally, the high performances of the Cu(I) complexes for the development of new 3D printing resins using LED projector are demonstrated. Currently, LED projector printing is really advantageous in 3D printing i.e. this technol. projects the profile of an entire layer at one time.3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole) was used in this study.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Aitha, Anjaiah’s team published research in Tetrahedron Letters in 2016 | CAS: 20154-03-4

In 2016,Aitha, Anjaiah; Yennam, Satyanarayana; Behera, Manoranjan; Anireddy, Jaya Shree published 《Design and synthesis of diaziridinyl quinone thiadiazole hybrids via nitrile sulfide cycloaddition reaction as a key step》.Tetrahedron Letters published the findings.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole The information in the text is summarized as follows:

A series of novel diaziridinyl quinone thiadiazole hybrids (I; R = N-heterocycle) were synthesized starting from 2-hydroxy-5-methoxybenzoic acid in a 7 step synthetic sequence. The key step in the scheme involves the nitrile sulfide cycloaddition reaction of oxathiazolone II with p-tosyl cyanide to obtain 1,2,4-thiadiazole derivative III. We have demonstrated that p-tosyl group of thiadiazole 5 can be displaced with various nitrogen heterocycles to generate unknown 3,5-disubstituted thiadiazole derivatives In the experiment, the researchers used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Quality Control of 3-(Trifluoromethyl)-1H-pyrazole)

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics