Category: 113100-53-1

Related Products of 113100-53-1,Some common heterocyclic compound, 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, molecular formula is C6H5F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 3 (7.5 mmol)And thionyl chloride (30 mmol) were mixed and heated under reflux for 4 hours,And then cooled, soot the excess to remove the amount of thionyl chloride to get yellowColor liquid compound 41-methyl-3- (trifluoromethyl) -1H-pyrazole-4-carboxylic acid chloride.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, its application will become more common.

Synthetic Route of 113100-53-1, These common heterocyclic compound, 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Intermediate 5 (1.0 mmol) and 4-dimethylaminopyridine (0.1 mmol) were added to a mixture of the corresponding carboxylic acid 6 (1.3 mmol) and (EDCI, 2 mmol) in CH2Cl2 (20 mL). The reaction system was stirred at room temperature overnight and then diluted with CH2Cl2 (50 mL). The resulting mixture was consecutively washed with 10% citric acid solution and brine. Then the organic phase was dried with sodium sulphate and filtered, and concentrated under reduced pressure. The residue was purified on a silica gel column to afford the title compounds 7-17.

Statistics shows that 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 113100-53-1.

Reference of 113100-53-1, A common heterocyclic compound, 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, molecular formula is C6H5F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1-methyl- 3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (400 mg, 2.06 mmol) in THF (6 mL) was added BH3.DMS (0.412 mL, 4.12 mmol) dropwise over 1 mm at 0 C under nitrogen. Thereaction was stirred at 0 C for 0.5 h, at 20 C for 0.5 h, and at 80 C for 3 h. Then the reaction was quenched with MeOH (20 mL) at 0 C, and the mixture was concentrated under reduced pressure to give the title compound, which was used directly in the next step without further purification. MS (ESI) m/z: 181.0 [M+Hj 1H NMR (400MHz, DMSO-d6) 3 = 7.81 (s, 1H), 5.12 (t, J=S.3 Hz, 1H), 4.40 (d, J5.1 Hz, 2H), 3.88 (s, 3H).

The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 113100-53-1, HPLC of Formula: C6H5F3N2O2

(1500 mg, 7.5 mmol) and SOCl2 (3500 mg, 30 mmol) was refluxedfor 4 h. After the reaction is completed, the excess of SOCl2 wasevaporated to give 4 as a yellow liquid that was used withoutfurther purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 113100-53-1

Reference Example 1 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (4′-chlorobiphenyl-2-yl) amide A solution of 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (0.68 g) and oxalyl chloride (0.49 g) in methylene chloride (30 ml) is stirred for 2 hours at room temperature in the presence of a catalytic amount of DMF. The resulting acid chloride solution is then added to a solution of 4′-chlorobiphenyl-2-ylamine (0.71 g) and triethylamine (0.36 g) in 15 ml of methylene chloride at 0C. The reaction mixture is then stirred for 4 hours at room temperature. After distilling off the solvent in a water-jet-vacuum, the residue is taken up in ethylacetate/water. The ethylacetate phase is extracted twice with water. After drying of the organic phase with Na2SO4, the solvent is distilled off in a water-jet-vacuum and the residue purified by column chromatography (silica gel; eluant: ethylacetate/hexane=1:1). 0.8 g of 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (4′-chlorobiphenyl-2-yl) amide are obtained in the form of slightly brownish crystals having a melting point of 144-146C.

According to the analysis of related databases, 113100-53-1, the application of this compound in the production field has become more and more popular.

113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Example P5: Preparation of 1 -Methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid (3-tert- butyl-2-vinylphenyl)amide; 197 mg (1 ,01 mmol) 1 -methyl-3-trifIuoromethyl-1 H-pyrazole-4-carboxyIic acid and 135 mg(1 ,07 mmol) oxalylic acid chloride are dissolved in 8 ml methylenechloride. The solution is stirred for 3 hours at room temperature in the presence of a catalytic amount of dimethylformamide (DMF). After this the solution is slowly added to a solution consisting of180 mg (1 ,01 mmol) 3-tert-butyl-2-vinyl-phenylamine, 155 mg (1 ,52 mmol) triethylamine and7 ml methylenechloride. The resulting reaction mixture is then stirred at room temperature for 16 hours. After removal of the solvent in a water jet vacuum, the residue is purified by flash chromatography over silicagel (eluent: hexane/ethylacetate 2:1). This gives 0,27 g 1- methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid (3-tert-butyl-2-vinylphenyl)amide in the form of a colourless solid (m.p. 118-119C; 76% of theory).

The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.

Application of 113100-53-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: carboxylic acid material (1.41 mmol) was dissolved in anhydrous dichloromethane (20 mL). Anhydrous DMF (2 drops)was added to the solution, followed by the dropwise addition of oxalyl chloride (536 mg, 4.22 mmol). The mixture was stirred overnight , and the solvent was removed in vacuo. The crude product acyl chloride (R1Cl) was used in the next step without further purification. R1Cl (1.33 g, 11.00 mmol) in dichloromethane was added dropwise to a stirred solution of intermediate 2 (10.00 mmol) and Et3N (0.87 g, 11.00 mmol) in dichloromethane (20 mL) at 0 oC. Stirring at room temperature was continued until TLC monitoring indicated total consumption of the intermediate 2. The reaction mixture was then evaporated to dryness, and the residue was purified by flash column chromatography on silica gel with ethyl acetate-petroleum ether (1:1) as eluent to yield the final products 3c-i.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Product Details of 113100-53-1

General procedure: Intermediate 5 (1.0 mmol) and 4-dimethylaminopyridine (0.1 mmol) were added to a mixture of the corresponding carboxylic acid 6 (1.3 mmol) and (EDCI, 2 mmol) in CH2Cl2 (20 mL). The reaction system was stirred at room temperature overnight and then diluted with CH2Cl2 (50 mL). The resulting mixture was consecutively washed with 10% citric acid solution and brine. Then the organic phase was dried with sodium sulphate and filtered, and concentrated under reduced pressure. The residue was purified on a silica gel column to afford the title compounds 7-17.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

113100-53-1, A common heterocyclic compound, 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, molecular formula is C6H5F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Pyrazole acid chlorides 6a-b were prepared by refluxing 4a-b in thionyl chloride for 8 h. Pyrazole acid chlorides 6a-b (12 mmol) in anhydrous tetrahydrofuran (THF; 30 mL) were slowly added to a solution of amine derivatives or 5-methylisoxazol-3-ol (10 mmol) and K2CO3 (1.38 g, 10 mmol) in anhydrous THF (30 mL) at a controlled temperature of 5 C. The reaction proceeded at room temperature until 6a-b was no longer tested by TLC. The reaction solution was then filtered and the solvent distilled. The residue was dissolved in ethyl acetate, washed with water and brine, dried over anhydrous sodium sulfate and recrystallized to generate the target pyrazole carboxamides and isoxazolol pyrazole carboxylates (7aa-bk). The product yields ranged from 40% to 80%. All 20 compounds were novel, and the physical and spectral data for these compounds are listed below.

The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.

113100-53-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 113100-53-1 name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid N’-[trans-4-(6-methoxy-3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexanecarbonyl]-hydrazide Trans-N’-4-(6-Methoxy-3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexanecarboxylic acid hydrazide (180 mg, 0.49 mmol), HATU (223 mg, 0.59 mmol), TEA (0.15 mL, 1.08 mmol) and 3-(trifluoromethyl)-1H-pyrazol-4-carboxylic acid (114 mg, 0.59 mmol) were dissolved in DMF (2 mL) and the mixture was left stirring overnight at r.t. The solvent was removed in vacuo and the crude was washed with MeOH to give the titled compound (75 mg, yield 33%). 1HNMR (DMSO) delta: 1.00-1.10 (2H, m), 1.27-1.37 (2H, m), 1.63-1.66 (2H, m), 1.73-1.76 (3H, m), 2.13-2.20 (1H, m), 3.27 (3H, s), 3.64 (2H, d, J=8.0 Hz), 3.74 (3H, s), 3.95 (3H, s), 6.62 (1H, dd, J=8.0 and 1.6 Hz), 6.85 (1H, d, J=1.6 Hz), 7.01 (1H, d, J=8.0 Hz) 8.32 (1H, s), 9.77 (1H, bs), 10.06 (1H, bs). C22H25F3N6O4 Mass (calculated) [508.50]. found [M+H+]=509, RT=1.17 (method f)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, and friends who are interested can also refer to it.