Category: 1120-82-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1120-82-7

1,4-bis(pyrazol-1-ylmethyl)-7-ethyl-1,4,7-triazacyclononane (L3) The ligand can be synthesised by heating 20 mmol Et-tacn (3.10 g), 40 mmol pyrazolylmethanol (3.92) (ref W. Driessen, Recl. Trav., Chim. Pays-Bas, 101, 441, 1982) and 0.4 g LiOH in 50 ml acetonitril for 20 hours under back-flow and argon atmosphere. The solution is filtered and the solvent is rotated off. The product has the form of a bright yellow oil. Yield: 6.3 g (80%). 1H-NMR (CDCl3- 400 MHz; 300K): 7.43 (d; 4H); 6.21 (s; 2H); 4.93 (s, 4H); 2.83(m; 8H); 2.62 (m; 4H); 2.53 (q; 2H); 0.95 (t, 3H); 13C-NMR: 139.0; 129.3; 125.9; 72.6; 54.3; 53.5; 52.7; 51.7; 12.3 ppm. MS (EI): m/z: 317.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1120-82-7.

1120-82-7, Adding a certain compound to certain chemical reactions, such as: 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1120-82-7.

General procedure: The target pyrazoly compounds (Scheme 2), were preparedin one step by condensation of one equivalent of (3,5-dimethyl-1H-pyrazol-1-yl) methanol ((1H-pyrazol-1-yl)methanol) with one equivalent of an appropriate amine in20 mL of acetonitrile (CH3CN) as solvent. All reactionswere carried out at reflux for 4 h. The liquid residue is driedover MgSO4, filtered and concentrated in vacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-1-yl)methanol, other downstream synthetic routes, hurry up and to see.

1120-82-7, name is (1H-Pyrazol-1-yl)methanol, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1120-82-7

To a solution of lH-pyrazol-1-ylmethanol (4.33 mg, 44.1 mmol) in anhydrous dichloromethane (130 mL) was added dropwise a solution of phosphorus tribromide (4.2 mL, 44.1 mmol) in anhydrous dichloromethane (20 mL) at 00C. The mixture was stirred for 2.5 hours at room temperature. The mixture was evaporated, and the crude l-(bromomethyl)-lH-pyrazole was used in the next step without purification.

Statistics shows that 1120-82-7 is playing an increasingly important role. we look forward to future research findings about (1H-Pyrazol-1-yl)methanol.

A common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1120-82-7.

General procedure: To a solution of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-hydroxybenzamide (12) (0.250g, 0.838mmol) in anhydrous THF (5mL), the corresponding alcohol (0.838mmol) and PPh3 (0.330g, 1.25mmol) were added. The reaction mixture was cooled on ice bath and DIAD (0.25mL, 1.25mmol) was added. The reaction was stirred overnight at room temperature. The solvent was evaporated under reduced pressure and the crude product was purified by flash chromatography.

The synthetic route of (1H-Pyrazol-1-yl)methanol has been constantly updated, and we look forward to future research findings.

1120-82-7, Adding some certain compound to certain chemical reactions, such as: 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1120-82-7.

Analogous method is applied for synthesis of LB as described for LA. The CH2Cl2 solution (10.0mL) of 2,6-diethylbenzenamine (3.29mL, 0.0200mol) was added a CH2Cl2 solution (30.0mL) of 1H-1-pyrazolyl-1-methanol (3.92g, 0.0400mol). The reaction solution was dried over the MgSO4 after stirring the reaction mixture at room temperature for 3days. The filtrate solvent was removed under reduced pressure to give bright yellow oil (5.54g, 89.5%). Anal. Calc. for C18H23N5: C, 69.8; H, 7.49; N, 22.6. Found: C, 68.1; H, 7.41; N, 21.6%. 1H NMR (CDCl3, 400MHz): delta 7.57 (d, 2H, J=2.0Hz, -N=CH-CH=CH-N-), 7.28 (d, 2H, J=2.0Hz, -N=CH-CH=CH-N-), 7.19 (t, 1H, J=7.2Hz, p-NC6H3(CH2CH3)2-), 7.09 (d, 2H, J=7.6Hz, m-NC6H3(CH2CH3)2-), 6.24 (t, 2H, J=2.0Hz, -N=CH-CH=CH-N-), 5.40 (s, 4H, -N-CH2-N-), 2.10 (q, 4H, J=7.6Hz, -NC6H3(CH2CH3)2-), 1.05 (t, 6H, J=7.6Hz, -NC6H3(CH2CH3)2-). 13C NMR (CDCl3, 100MHz): delta 142.94 (s, 1C, ipso-NC6H3(CH2CH3)2), 142.41 (s, 2C, o-NC6H3(CH2CH3)2-), 139.90 (d, 2C, J=183Hz, -N=CH-CH=CH-N-), 129.27 (d, 2C, J=184Hz, -N=CH-CH=CH-N-), 127.25 (d, 2C, J=158Hz, m-NC6H3(CH2CH3)2-), 126.42 (d, 1C, J=156Hz, p-NC6H3(CH2CH3)2-), 105.95 (d, 2C, J=176Hz, -N=CH-CH=CH-N-), 68.85 (t, 2C, J=149Hz, -N-CH2-N-), 23.00 (t, 2C, J=125Hz, -NC6H3(CH2CH3)2-), 14.75 (q, 2C, J=125Hz, -NC6H3(CH2CH3)2-). IR (liquid neat; cm-1): 3845 (w), 3743 (w), 3617 (w), 3110 (w), 2967 (m), 1702 (w), 1151 (m), 1457 (m), 1392 (m), 1264 (s), 1159 (s), 1083 (s), 1042 (s), 962 (m), 873 (w), 812 (w), 744 (s), 653 (w), 616 (m), 581 (w).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1120-82-7.