Category: 15366-34-4

Formula: C5H6N2O2In 1976 ,《Modified nucleosides. V. Synthesis of pyrazole nucleosides》 appeared in Zhurnal Obshchei Khimii. The author of the article were Akhrem, A. A.; Garbuz, N. I.; Kvasyuk, E. I.; Mikhailopulo, I. A.. The article conveys some information:

Pyrazole nucleosides I, II (R = Ac, R1 = OEt) were obtained in 52 and 26% yields by treatment of Et acetoxymethylpyrazolecarboxylate with α-D-glucopyranose pentaacetate. Subsequent aminolysis yielded 90% I, II (R = H, R1 = NH2). Analogously obtained were 71 and 11% III, IV (R = Bz, R1 = Ac, R2 = OEt) which were treated with NH3 to give 90% III, IV (R = R1 = H, R2 = NH2). Similar results were obtained by glucosylation of Me pyrazolecarboxylate and by ribosylation of Et 4-acetoxymethyl-3-pyrazolecarboxylate. The experimental part of the paper was very detailed, including the reaction process of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Computed Properties of C5H6N2O2In 2004 ,《Synthesis and luminescence properties of lanthanide(III) chelates with polyacid derivatives of thienyl-substituted terpyridine analogues》 was published in Journal of Luminescence. The article was written by Yuan, Jingli; Tan, Mingqian; Wang, Guilan. The article contains the following contents:

Two new polyacid derivative ligands of thienyl-substituted terpyridine analogs, N,N,N1,N1-[4′-(2”’-thienyl)-2,2′:6′,2”-terpyridine-6,6”-diyl]bis(methylenenitrilo) tetrakis(acetic acid) (TTTA) and N,N,N1,N1-[2,6-bis(3′-aminomethyl-1′-pyrazolyl)-4-(2”-thienyl)pyridine]tetrakis(acetic acid) (BTTA), were synthesized, and the luminescence properties of their Eu3+ and Tb3+ chelates were studied. The Eu3+chelates of the two ligands are strongly luminescent having luminescence quantum yields of 0.150 (TTTA-Eu3+) and 0.114 (BTTA-Eu3+), and lifetimes of 1.284 ms (TTTA-Eu3+) and 1.352 ms (BTTA-Eu3+), whereas their Tb3+ chelates are weakly luminescent. The TTTA-Eu3+ chelate was used for streptavidin (SA) labeling, and the labeled SA was used for time-resolved fluoroimmunoassay of insulin in human sera. The method gives the detection limits of 33 pg ml-1. In the part of experimental materials, we found many familiar compounds, such as Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Computed Properties of C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 15366-34-4In 2005 ,《A Theoretical Study on the Tautomerism of C-Carboxylic and Methoxycarbonyl Substituted Azoles》 was published in Structural Chemistry. The article was written by Alkorta, Ibon; Elguero, Jose. The article contains the following contents:

DFT calculations (B3LYP/6-31+G**) have been carried out on 106 tautomers and conformers of NH-azoles bearing CO2H and CO2CH3 groups. The following azoles systems have been studied: 2-substituted pyrroles, 2-substituted indoles, 2-substituted imidazoles, 2-substituted benzimidazoles, 4(5)-substituted imidazoles, 3(5)-substituted pyrazoles, 3-substituted indazoles (1H and 2H), 3,4(5)-substituted-1,2,3(5)-triazoles, 2,3(5)-substituted-1,2(3),4-triazoles, 4(5)-1,2,3,4(5)-tetrazoles. In the case of pyrazole, 3,5-disubstituted derivatives have also been computed, including four dimers. The results came from multiple reactions, including the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Related Products of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Related Products of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1960,Reimlinger, Hans K. published 《Bisdiazoalkanes. II. The preparation of bispyrazolylalkane derivatives》.Chemische Berichte published the findings.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

cf. CA 53, 15060d. Alkynes, activated by α-CO groups, yielded with bisdiazoalkanes in solution or in situ ringsubstituted bispyrazolylalkanes. The reaction of nascent monodiazoalkanes with (CCO2Me)2 (I) gave, depending on the reaction conditions, the expected di-Me pyrazoledicarboxylate (II) together with di-Me bis(dicarbomethoxypyrazolyl)succinate (III) or its alkylated derivatives The III was formed from I with II by a Michael-type addition reaction; the addition which occurred on the pyrazole-N was reversible. HCCCO2Me (IV) yielded in an analogous reaction an acrylic ester derivative, substituted on the pyrazole-N. Na2SO4 (1 g.) and 47 mmoles I in 200 cc. dry Et2O treated at -5° with 1 g. K2CO3, the mixture cooled to -10°, treated dropwise below -5° with stirring with 94 mmoles N,N’-dinitroso-N,N’-diacetylalkylenediamine in 50 cc. absolute MeOH, the mixture stirred 5 hrs. with cooling, filtered, the residue washed with H2O, and recrystallized from hot H2O gave the corresponding bis(4,5-dicarbomethoxy-3-pyrazolyl)alkane (V); the filtrate neutralized with AcOH and evaporated in vacuo gave a dark brown N-free sirup; in this manner were prepared the following V (number of C atoms of alkane chain, m.p., and % yield given): 1, 179-81°, 22; 2 (VI), 199°, 22; 4, 180-1°, 16; 6, 107°, 20; 8, 98-9°, 30. The pentamethylene derivative could only be obtained as a crude brown sirup. VI (2 g.) in 200 cc. 2N H2SO4 refluxed 2 days, cooled, and filtered yielded 1 g. hygroscopic 1,2-bis(4,5-dicarboxy-3-pyrazolyl)ethane (VII), decomposed at 260°. VII (1 g.) added in small portions to excess CH2N2-Et2O, the mixture treated with AcOH, and evaporated yielded 1 g. N,N’-di-Me derivative of VI. [(CH2)4NH2]2 (50 g.) in 200 cc. C6H6 treated dropwise with 40 cc. Ac2O, the mixture stirred 15 min., and filtered gave 76% [AcNH(CH2)4]2 (VIII), m. 130° (Me2CO). VIII in AcOH-Ac2O treated with nitrous gases, poured onto crushed ice, and filtered yielded 96% [AcN(NO)(CH2)4]2 (IX), m. 55-6°. IV (6 g.) in 200 cc. Et2O treated dropwise at 0° with (CH2CH2CHN2)2 in Et2O and filtered after 1 hr. gave 70% 1,4-bis(5-carbomethoxy-3-pyrazolyl)butane, m. 183-4° (H2O). (BzC)2 (10 g.) in 100 cc. Et2O treated in the usual manner with IV yielded 11.8 g. (crude) 1,4-bis(5-benzoyl-3-pyrazolyl)butane, m. 191° (MeOH). I (14.2 g.) and 2 g. Na2SO4 added to 100 cc. Et2O, the mixture cooled to 0°, treated with 2 g. K2CO3 and then during 15 min. with stirring with 10 g. [AcN(N0)CH2]2 (X) in 75 cc. MeOH, and filtered after 2 hrs. yielded 500 mg. 4,4′,5,5-tetracarbomethoxy-3,3′-bipyrazolyl, needles, m. 170° (2:1 C6H6-EtOH). Dry Et2O (100 cc.), 2 g. K2CO3, 2 g. Na2SO4, and 11.3 g. AcN(NO)Me (XI) treated dropwise at 10-15° with 14.2 g. I in 50 cc. MeOH, filtered, and the residue treated with hot H2O left 3.4 g. di-Me α,α’-bis[3,4(4,5)-dicarbomethoxy-1-pyrazolyl]succinate (XII), decomposed at 191°; the Et2O solution evaporated and the residue recrystallized from the aqueous filtrate gave 9 g. di-Me 3,4-dicarbomethoxypyrazole (XIII), m. 141°. A similar run in which MeOH was added to a mixture of I, XI, K2CO3, and Na2SO4 in Et2O yielded 93% XII. A run in which I in MeOH was added to XI, K2CO3, and Na2SO4 in Et2O gave 20% XII and 48% XIII; the XI in MeOH added to I, K2CO3, and Na2SO4 in Et2O gave 74% XII; the I and XI in MeOH added to K2CO3 and Na2SO4 in Et2O yielded 25% XII and 42% XIII. I (2.9 g.) and 3.7 g. XIII in 70 cc. Et2O and 35 cc. MeOH refluxed 4 hrs. and evaporated, the viscous residue heated 1 day on the water bath, diluted with Et2O, filtered, the residue digested with boiling H2O, and filtered left 300 mg. XII. I (4.6 g.) and 4 g. XIII in 50 cc. MeOH and 100 cc. Et2O treated with a few drops concentrated NaOMe in MeOH and filtered after 2 days yielded 4.3 g. XII. XII (5 g.) in 50 cc. MeOH, containing a small piece of Na, neutralized immediately with AcOH, evaporated, the residue treated with petr. ether, filtered, and the filtrate evaporated gave a few drops of oily I; the petr. ether-insoluble solid (1.5 g.) was XIII, m. 141°. XII (3 g.) heated slowly under N to 190°, kept 1 min. at 190°, cooled, treated with boiling H2O, filtered, and the filtrate cooled gave 0.2 g. XIII; 0.2 g. 2nd crop; the H2O-insoluble solid treated with AcOH gave 2.1 g. XII. XII (10 g.) in 200 cc. 2N HNO3 refluxed 2 days, filtered hot, and cooled gave hydrated 3,4-dicarboxypyrazole (XIV), needles, decomposed at 263-4°, which dried 1 day over P2O5 in a desiccator gave XIV.H2O and dried further at 80° over P2O5 gave XIV; the aqueous acidic filtrate extracted 3 days with Et2O, the extract evaporated, and the residue treated with the calculated amount of CH2N2 yielded XIII. XIV and XIII treated with excess CH2N2 yielded the N-Me derivative of XIII, b11 124-5°. XIII (1 g.) in 25 cc. ClCO2Et refluxed 1.5 hrs., evaporated in vacuo, and cooled yielded 77% N-MeO2C derivative of XIII, m. 73° (H2O). I (3.4 g.) and 3.55 g. I. in 50 cc. Et2O treated with a few drops of concentrated NaOMe-MeOH and filtered after standing overnight yielded 0.5 g. di-Me α,α’-di(1-pyrazolyl)succinate (XV), m. 139° (hot H2O). Pyrazole K derivative in dry C6H6 from 5 g. pyrazole treated slowly dropwise with 5 g. (CHClCO2Me)2 in 50 cc. C6H6, the mixture refluxed 0.5 hr., washed with H2O, and worked up yielded 22.4% XV. I (10 g.) and 1 g. Na2SO4 added to 200 cc. dry Et2O, the mixture cooled to -2°, treated with 1 g. K2CO3 and then dropwise during 2.5 hrs. with 6.9 g. X in 130 cc. absolute MeOH, the mixture cooled to -10°, and filtered gave 25% 1-(1,2-dicarbomethoxyvinyl)-4,4′,5,5-tetracarbomethoxy-3,3′-bipyrazolyl, m. 220° (H2O). XI (13 g.) and 14.2 g. I in 50 cc. Et2O treated with 2 g. Na2SO4 and 3 g. K2CO3, the mixture treated dropwise at 15-20° with 25 cc. MeOH, and filtered after 2 hrs. yielded 7 g. di-Me α,α’bis[5(3)-methyl-3,4(4,5)-dicarbomethoxy-1-pyrazolyl] succinate (XVI), decomposed at 143-4°; 0.7 g. 2nd crop; the aqueous filtrate neutralized with AcOH and evaporated, the residue extracted with C6H6, and the oily residue from the extract digested with petr. ether yielded 15% 5(3)-methyl-3,4(4,5)dicarbomethoxypyrazole (XVII), m. 106°, also obtained from I and MeCHN2. AcN(NO)Pr (10 g.) in 50 cc. Et2O treated with 2 g. Na2SO4 and 3 g. K2CO3 and then during 2 hrs. with stirring at 10-15° with 9.7 g. I in 50 cc. MeOH, the mixture filtered after standing overnight, neutralized with AcOH, evaporated in vacuo, and the residue reprecipitated from dioxane with H2O yielded 3.3 g. 5(3)-Et analog of XVI, prisms, decomposed at 123.5° (MeOH); the aqueous dioxane filtrate evaporated and distilled gave 3 g. 5(3)-Et analog of XVII, b0.05 150-2°. AcNHC18H37 in 200 cc. Ac2O-AcOH treated 7 hrs. with nitrous gases and poured onto ice and H2O yielded 94.5% AcN(NO)C18H37 (XVIII), lemon-yellow, m. 43-4° (Me2CO). I (7.1 g.) and 19 g. XVIII in 50 cc. Et2O treated with 1 g. Na2SO4 and 1.5 g. K2CO3 and then during 2 hrs. with 25 cc. MeOH, the mixture filtered after 3 hrs., the residue dissolved in MeOH, and cooled to -40° yielded 64% 1-(N-octadecyldicarbomethoxypyrazolyl)heptadecane, m. 47°. Ba(OH)2 (3 g.) in 50 cc. Et2O and 50 cc. MeOH treated during 2 hrs. with 15.5 g. I and 18 g. AcN(NO)Bu below 25°. the mixture filtered, neutralized with AcOH, evaporated in vacuo, the red-brown viscous residue (21 g.) diluted with Et2O, filtered, evaporated, and the viscous residue (17 g.) fractionated gave 12 g. 5(3)-Pr analog of XVII, b0.0001 140°. I (14.2 g.) and 15 g. AcN(NO)CH2CH2OMe gave in the usual manner 21.5 g. (crude) 5(3)-MeOCH2CH2 analog of XVII, b0.0001 154-6°. IV (8.4 g.) in 100 cc. Et2O and 12 g. XI in 50 cc. MeOH yielded with 2 g. Na2SO4 and 2 g. K2CO3 9.5 g. 3(5)-carbomethoxypyrazole (XIX), m. 142° (MeOH). XI (9.5 g.) in 50 cc. MeOH and 13.3 g. IV in 50 cc. Et2O with 2 g. Na2SO4 and 2 g. K2CO3 gave Me β-(3)-carbomethoxy-1-pyrazolyl]acrylate (XX), m. 110-10.5° (H2O). IV (1.7 g.) and 2.5 g. XIX in 30 cc. MeOH treated with 3 drops concentrated NaOMe-MeOH, the mixture heated 1 hr. on the water bath, and kept 7 days gave 300 mg. XX, m. 110°. After reading the article, we found that the author used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Application In Synthesis of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2010,Lyalin, B. V.; Petrosyan, V. A.; Ugrak, B. I. published 《Electrosynthesis of 4-iodopyrazole and its derivatives》.Russian Chemical Bulletin published the findings.Product Details of 15366-34-4 The information in the text is summarized as follows:

Electrosynthesis of 4-iodopyrazoles I (R1 = Me, O2N, H, etc.; R2 = H, Me) in up to 86% yields by iodination of the corresponding precursors on a Pt-anode in aqueous solutions of KI under conditions of the diaphragm galvanostatic electrolysis is reported.Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Product Details of 15366-34-4) was used in this study.

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Product Details of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Sun, Mingli; Zhou, Yuhui; Li, Laiqiang; Wang, Lei; Ma, Yongmin; Li, Pinhua published an article in 2021. The article was titled 《Electrochemically promoted C-3 amination of 2H-indazoles》, and you may find the article in Organic Chemistry Frontiers.Computed Properties of C5H6N2O2 The information in the text is summarized as follows:

A metal-free and external oxidant-free electrochem. method for the C-3 amination of 2H-indazoles was reported for the synthesis of indazolyl-amines I [R = n-Bu, 1-pyrazolyl, morpholino, etc.; R1 = H, 5-F, 6-Br, etc.; R2 = Ph, 1-naphthyl, 2-pyridyl, etc.]. The protocol employed com. available azoles and aliphatic amines as amination reagents and had a broad substrate scope, providing the corresponding C3-amination products in high yields at room temperature Mechanistic studies indicated that an oxidative addition/elimination sequence was involved under electrochem. conditions. In the part of experimental materials, we found many familiar compounds, such as Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1956,Monte, Dea Dal; Mangini, Angelo; Passerini, Riccardo published 《Heterocyclics-ultraviolet absorption spectra and chromophoric properties. III. Pyrazoles and phenylpyrazoles》.Gazzetta Chimica Italiana published the findings.Quality Control of Methyl 1H-pyrazole-3-carboxylate The information in the text is summarized as follows:

Fifty known substituted pyrazoles and phenylpyrazoles were prepared and their near ultraviolet absorption spectra were recorded in alc., alc.-water, cyclohexane, HCl, and alkali. Spectra were plotted, and absorption maximum and mol. extinction coefficients were tabulated. Substituents were Me, CO2R, Et, NH2, and NO2. Changes in spectra, mol. refraction, and basicities for pyrazole and Me derivatives confirmed a hyperconjugation effect for Me in 5- and 3-positions. Pyrazolecarboxylic acids and esters showed conjugation of CO with ring. The 208 mμ band was associated with the chromophore C:CCO2H. The 200-210 mμ band in pyrazole was assigned to the first excited level, antisymmetric combination, type B1. N-Phenylpyrazole showed conjugation between rings or between ring and imine, depending on substitution position, while 5-Me and 2-Me compounds were sterically hindered. Nitration in position 4 or 4′ caused conjugation of NO2 with imine.Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Quality Control of Methyl 1H-pyrazole-3-carboxylate) was used in this study.

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Quality Control of Methyl 1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1999,Storer, Richard; Ashton, Claire J.; Baxter, Anthony D.; Hann, Michael M.; Marr, Clara L. P.; Mason, Andrew M.; Mo, Chi-Leung; Myers, Peter L.; Noble, Stewart A.; Penn, Harles R.; Weir, Niall G.; Woods, Jacqueline M.; Coe, Paul L. published 《The synthesis and antiviral activity of 4-fluoro-1-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide》.Nucleosides & Nucleotides published the findings.COA of Formula: C5H6N2O2 The information in the text is summarized as follows:

A novel fluoropyrazole ribonucleoside has been shown to have significant anti-influenza activity in vitro. The compound is compared and contrasted with the structurally-related compound ribavirin in attempts to identify factors having significant bearing on the mode of action of both compounds The experimental process involved the reaction of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4COA of Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.COA of Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2017,Lee, Eun; An, Ying; Kwon, Junhee; Kim, Keun Il; Jeon, Raok published 《Optimization and biological evaluation of 2-aminobenzothiazole derivatives as Aurora B kinase inhibitors》.Bioorganic & Medicinal Chemistry published the findings.Product Details of 15366-34-4 The information in the text is summarized as follows:

A strong relationship between abnormal functions of Aurora kinases and tumorigenesis has been reported for decades. Consequently, Aurora kinases serve as potential targets for anticancer agents. Here, we identified aminobenzothiazole derivatives as novel inhibitors of Aurora B kinase through bioisosteric replacement of the previous inhibitors, aminobenzoxazole derivatives Most of the urea-linked aminobenzothiazole derivatives showed potent and selective inhibitory activity against Aurora B kinase over Aurora A kinase. Mol. modeling indicated that compound I bound well to the active site of Aurora B kinase and formed the essential hydrogen bonds. The potent compounds, I and II, were selected, and their biol. effects were evaluated using HeLa cell lines. It was found that these compounds inhibited the phosphorylation of histone H3 at Ser10 and induced G2/M cell cycle arrest. We suggest that the reported compounds have the potential to be further developed as anticancer therapeutics. In addition to this study using Methyl 1H-pyrazole-3-carboxylate, there are many other studies that have used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Product Details of 15366-34-4) was used in this study.

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Product Details of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1989,Coe, Paul L.; Cook, Michael I. published 《Reactions of tetrafluoroethene oligomers. Part XII. Cycloaddition reactions of 3,3,4,4,4-pentafluoro-2-(pentafluoroethyl)-2-(trifluoromethyl)diazobutane. A novel synthesis of pyrazoles》.Journal of Fluorine Chemistry published the findings.Computed Properties of C5H6N2O2 The information in the text is summarized as follows:

The title diazoalkane I reacts smoothly with a variety of electron-deficient alkenes to give, unexpectedly, pyrazole derivatives Thus, reaction with Me or Et propenoate affords the Me and Et esters of pyrazole-3-carboxylic acid. Reaction with di-Et maleate yields 3,4-bis(ethoxycarbonyl)pyrazole, and di-Me maleate gives the di-Me ester II. Treatment of I with propenonitrile afforded 3-cyanopyrazole, and with propenoic acid pyrazole-3-carboxylic acid was obtained. In all of these reactions two side products were isolated, namely perfluoro(3-methylpent-2-ene) and 3H-3-trifluoromethyldecafluoropentane. A mechanistic rationale for these unusual and potentially useful reactions is given. The experimental part of the paper was very detailed, including the reaction process of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics