Category: 5334-40-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Formula: C4H3N3O4

Synthesis of 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester A 20 L reaction vessel equipped with a digital thermometer and stirrer was charged with 4-nitro-1H-pyrazole-3-carboxylic acid (1.117 Kg, 7.11 mol, 1 wt) and methanol (8.950 L, 8 vol). The reaction mixture was stirred under nitrogen, cooled to 0 to 5 C., thionyl chloride (0.581 L, 8.0 mol, 0.52 vol) added over 180 minutes and the resultant mixture allowed to warm to and stir at 18 to 22 C. overnight after which time 1H NMR analysis (d6-DMSO) indicated reaction completion. The reaction mixture was concentrated under reduced pressure at 40 to 45 C., the residue treated with toluene and re-concentrated (3*2.250 L, 3*2 vol) under reduced pressure at 40 to 45 C. to give 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester as an off-white solid (1.210 Kg, 99.5% th).

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; US2010/55094; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 5334-40-7

A mixture of 4-nitro-3-pyrazolecarboxylic acid (4.98 g, 31.7 mmol), trans 4-aminocyclohexanol (3.65 g, 31.7 mmol), EDAC (6.68 g, 34.8 mmol) and HOBt (4.7 g, 34.8 mmol) in DMF (120 ml) was stirred at ambient temperature for 16 hours. The mixture was reduced in vacuo, the residue taken up in CH2CI2 and washed successively with 5percent citric acid, saturated aqueous sodium bicarbonate, water and brine. The product was found to be mainly in the citric acid wash, which was basified and extracted with EtOAc. The organic layer was dried over MgSO4, filtered and evaporated to give a white solid, which was triturated with CHCI3 to give 1.95 g of 4-nitro-1H-pyrazole-3-carboxylic acid 4-hydroxy-cyclohexylamide. (LC/MS: Rt 1.62, [M+H]+255).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5334-40-7, its application will become more common.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; WO2006/77424; (2006); A1;; ; Patent; ASTEX THERAPEUTICS LIMITED; WO2006/77425; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 5334-40-7, These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Stage 4: Synthesis of 4-nitro-lH-pyrazole-3-carboxylic acid methyl ester; A 2OL reaction vessel equipped with a digital thermometer and stirrer was charged with 4- nitro-lH-pyrazole-3-carboxylic acid (1.117Kg, 7.11mol, lwt) and methanol (8.950L, 8vol). The reaction mixture was stirred under nitrogen, cooled to 0 to 50C, thionyl chloride (0.581L, 8.0mol, 0.52vol) added over 180 minutes and the resultant mixture allowed to warm to and stir at 18 to 22C overnight after which time 1H NMR analysis (d6-DMSO) indicated reaction completion. The reaction mixture was concentrated under reduced pressure at 40 to 450C, the residue treated with toluene and re-concentrated (3x 2.250L, 3x 2vol) under reduced pressure at 40 to 45C to give 4-nitro-lH-pyrazole-3-carboxylic acid methyl ester as an off-white solid (1.210Kg, 99.5%th).; Stage 4: Preparation of 4-nitro-lH-pyrazole-3-carboxylic acid methyl; esterC4H3N3O4 C5H5N3O4FW: 157.09 FW: 171.114-Nitro-lH-pyrazole-3-carboxylic acid (1.00kg, 6.37mol, l.Owt) and methanol (8.00L, 8.0vol) were charged to a flange flask equipped with a mechanical stirrer, condenser and thermometer. The suspension was cooled to 0 to 5C under nitrogen and thionyl chloride (0.52L, 7.12mol, 0.52vol) was added at this temperature. The mixture was warmed to 15 to 25C over 16 to 24 hours. Reaction completion was determined by 1H NMR analysis (dbeta-DMSO). The mixture was concentrated under vacuum at 35 to 45C. Toluene (2.00L, 2.0vol) was charged to the residue and removed under vacuum at 35 to 45C. The azeotrope was repeated twice using toluene (2.00L, 2.0vol) to give 4-nitro-lH-pyrazole-3-carboxylic acid methyl ester (1.071Kg, 98.3%) as an off white solid.

Statistics shows that 4-Nitro-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5334-40-7.

Electric Literature of 5334-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

General Procedure J; Preparation of a 4-amino-1H-pyrazole-3-carboxylic acid amideStep J (T). Preparation of a 4-nitro-1H-pyrazole-3-carboxylic acid amide4-Nitropyrazole-3-carboxylic acid (10 g; 63.66 mmol, 1 equiv.) was added to a stirred solution of an amine RNH2 (70 mmol, 1.1 equiv.), EDC (14.6 g; 76.4 mmol, 1.2 equiv.), and HOBt (10.3 g; 76.4 mmol, 1.2 equiv.) in DMF (250 ml), then stirred at room temperature overnight. The solvent was removed by evaporation under reduced pressure and the residue triturated with ethyl acetate / saturated brine solution. The resultant solid was collected by filtration, washed with 2M hydrochloric acid, then dried under vacuum to give 15.5 g of the amide compound.

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., name: 4-Nitro-1H-pyrazole-3-carboxylic acid

[00842] Example 209: 4- [ (Aminocarbonyl) amino]-l- (3-chloro-4- methoxyphenyl)-1 H-pyrazole-3-carboxamide; [00844] Step 1: Preparation of ethyl 4-nitro-1 H-pyrazole-3-carboxylate [00846] 4-Nitro-1 H-pyrazole-3-carboxylic acid (2 g, 12.73 mmol ; Aldrich) was refluxed in absolute ethanol (25 mL) containing trace sulfuric acid (0. 2. mol) for 5 h. The reaction was evaporated and partitioned between EtOAc and 5% NaHCO3. The EtOAc layer was separated, dried over MgSO4 and filtered. The EtOAc was removed to give a white solid.’H. NMR (300 MHz, DMSO-d6) : 5 1.28 (t, J=7 Hz, 3 H), 4. 34 (q, J=7 Hz, 2 H), 8.91 (s, 1 H), 14.39 (br s, 1 H); MS (ESI+) for CH N 186. 1 (M+H) +.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C4H3N3O4

4-(2-Thio-5-azabicyclo[2.2.1]heptane-5-ylmethyl)benzene-1,2-diamine (0.7 g, 3 mmol), 4-nitro-1 hydrogen -pyrazole-3-carboxylic acid (0.47 g, 3 mmol)Dissolved in DMF (15 mL) followed by EDCI (0.63 g, 3.3 mmol)HOBt (0.45 g, 3.3 mmol) was stirred at room temperature for 24 hours.The solvent was removed under reduced pressure, and acetic acid (20 mL) was evaporated.After completion of the reaction, concentration and purification by column (dichloromethane/methanol (v/v) = 10/1),The product was obtained (0.5 g, 50percent).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 5334-40-7, These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Nitro-1H-pyrazole-3-carboxylic acid (20 g, 127.3 mmol) was dissolved in methanol (200 mL) and thionyl chloride (22.7 g, 190.8 mmol) was added and reacted at 20 C for 16 hours. The reaction was completed and concentrated. Methyl tert-butyl ether (200 mL) was added and filtered to give 20 g of the title product in 91.7% yield.

Statistics shows that 4-Nitro-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 5334-40-7.

Application of 5334-40-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5334-40-7 as follows.

A solution of l-methanesulphonyl-piperidin-4-ylamine hydrochloride (2.4 g, 11.1 mmoles), 4-nitro-1H-pyrazole-3-carboxylic acid (1.8 g, 11.1 mmoles), EDC (2.6 g (13.5 mmoles), HOBt (1.8 g, 13.3 mmoles) and triethylamine (3.4 ml, 24.6 mmoles) in DMF (30 ml) was stirred at room temperature for 24 hours. The reaction mixture was partitioned between EtOAc and a saturated solution of sodium hydrogen carbonate. The organic portion was dried (MgSO4), filtered and evaporated in vacuo to give 4-nitro-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl- piperidin-4-yl)-amide as a pale orange solid (1.7g, 48percent).

According to the analysis of related databases, 5334-40-7, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C4H3N3O4

Thionyl chloride (3.8 ml, 52.5 mmol) was added cautiously to a stirred, ice-cold mixture of 4-nitropyrazole-3-carboxylic acid (7.5 g, 47.7 mmol) in MeOH (150 ml), the mixture stirred at ambient temperature for 1 hour then heated at reflux for 3 hours. The reaction mixture was cooled, evaporated in vacuo then azeotroped with toluene to give 4-nitro-lH-pyrazole-3-carboxylic acid ethyl ester (8.8 g).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5334-40-7.

Related Products of 5334-40-7,Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 2OL reaction vessel equipped with a digital thermometer and stirrer was charged with 4-nitro-1H-pyrazole-3- carboxylic acid (1.117 Kg, 7.11 mol, 1 wt) and methanol (8.950 L, 8 vol). The reaction mixture was stirred under nitrogen, cooled to 0 to 5 C, thionyl chloride (0.581 L, 8.0 mol, 0.52 vol) added over 180 minutes and the resultant mixture allowed to warm to and stir at 18 to 22 C overnight, after which time 1H NMR analysis (dbeta- DMSO) indicated reaction completion. The reaction mixture was concentrated under reduced pressure at 40 to 45 C, the residue treated with toluene and re-concentrated (3x 2.250 L, 3x 2vol) under reduced pressure at 40 to 45 C to give 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester as an off-white solid (1.210 Kg, 99.5%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole-3-carboxylic acid, its application will become more common.