Category: 82560-12-1

Adding a certain compound to certain chemical reactions, such as: 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82560-12-1, COA of Formula: C7H13N3

3-Tert-butyl-1 H-pyrazol-5-amine (J-lll) (1 equivalents, 40 g) was dissolved in diluted HCI (120 mL of HCI in 120 mL of water) and mixed dropwise with NaN02 (1 .03 equivalents, 25 g in 100 mL) at 0 – 5 C over a period of 30 min. After stirring for 30 minutes, the reaction mixture was neutralised with Na2C03. A diazonium salt obtained by reaction of KCN (2.4 equivalents, 48 g), water (120 mL) and CuCN (1 .12 equivalents, 31 g) was added dropwise to the reaction mixture within 30 min and the mixture was stirred for a further 30 min at 75 C. After complete reaction, the reaction mixture was extracted with ethyl acetate (3 x 500 mL), the combined organic phases were dried over sodium sulphate and the solvent was removed under vacuum. The purification (silica gel: 100-200 mesh, eluent: 20 % ethyl acetate/n-hexane) of the residue by column chromatography produced a white solid (J-IV) (6.5 g, 15 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-tert-butylpyrazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 82560-12-1,Some common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, molecular formula is C7H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2,4-dichloropyrimidine (3.73g, 25mmol) and 5-amino-3-tert-butyl-lH- pyrazole (3.55g, 25.5mmol) and DIPEA (4.44ml, 25mmol) were heated at 5O0C in TEtaF25 (75ml) for 18 hours under nitrogen. The mixture was allowed to cool and the volatiles removed by evaporation. The residue was dissolved in DCM (150ml), washed with water, dried (MgSO4) and the solvent removed by evaporation. The residue was purified by chromatography on silica gel eluting with EtOAc/hexanes (1:3) and then methanol/DCM (5:95) to give 2-chloro-4-(5-tert-butyl-lH-rhoyrazol-3-ylamino)rhoyrimidine (1.73g, 28%). NMR30 Spectrum 1.30 (s, 9Eta), 6.05 (s, IH), 7.16 (br s, IH), 8.12 (d, IH), 9.80 (br s, IH), 11.89 (br s, IH); Mass Spectrum 252 [MH]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-5-tert-butylpyrazole, its application will become more common.

Electric Literature of 82560-12-1, These common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-(tert-butyl)-lH-pyrazol-5-amine (1.00 g, 7.20 mmol) in toluene (13 mL) was added 5-bromo-2-fluorophenol (1.51 g, 7.90 mmol), potassium carbonate (2.08 g, 15.1 mmol), (IS, 2S)-N,N’-bis-methyl-l,2-cyclohexane-diamine (0.20 g, 1.40 mmol) then copper (I) iodide (0.07 g, 0.36 mmol). The mixture was degassed then heated at 150 C for 1 h using microwave irradiation. Another portion of copper (I) iodide (0.07 g, 0.36 mmol) was added and the reaction mixture heated at 150 C for a further 1 h using microwave irradiation. The mixture was diluted with EtOAc and water and the phases separated. The aqueous layer was then extracted with EtOAc (2 x). The combined organic layers were washed with brine, dried (Na2S04), filtered and evaporated in vacuo to give an impure solid. The residue was partitioned between DCM and water and the phases separated. The organic layer was evaporated in vacuo and the residue was purified by FCC, using 0-5% MeOH in DCM. Further purification by FCC, using 0-25% EtOAc in DCM, gave the title compound as an orange gum (1.25 g, 70%>). LCMS (Method 3): Rt 2.33 min, m/z 250.3 [MH+].

Statistics shows that 3-Amino-5-tert-butylpyrazole is playing an increasingly important role. we look forward to future research findings about 82560-12-1.

Synthetic Route of 82560-12-1,Some common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, molecular formula is C7H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-tert-butyl-1H-pyrazol-5-amine (J-III) (1 equiv., 40 g) was dissolved in dilute HCl (120 mL HCl in 120 mL water) and NaNO2(1.03 equiv., 25 g in 100 mL) was added dropwise over 30 min. After stirring for 30 min the reaction mixture was neutralised with Na2CO3. A diazonium salt obtained by reacting KCN (2.4 equiv., 48 g), water (120 mL) and CuCN (1.12 equiv., 31 g) was added dropwise within 30 min to the reaction mixture, which was then stirred for a further 30 min at 75 C. After complete conversion the reaction mixture was extracted with EE (3¡Á500 mL), the combined phases were dried over sodium sulphate and the solvent was removed in vacuo. The column chromatography purification (SiO2, 20% EE/Hexane) of the residue yielded a white solid (J-IV) (6.5 g, 15.1% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-5-tert-butylpyrazole, its application will become more common.

82560-12-1, name is 3-Amino-5-tert-butylpyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 82560-12-1

lution of Intermediate 11a (444 mg, 1.9 mmol), 3-tert-butyl- lH- pyrazole-5-amine (312 mg, 2.2 mmol) and trans-N,N’-dimethyl-cyclohexane- diamine (53.0 mg, 0.4 mmol) was formed in toluene (5 mL). Potassium carbonate (543 mg, 3.9 mmol) was added and the mixture degassed by bubbling nitrogen through it. Copper(I) iodide (36.0 mg, 0.2 mmol) was added and the mixture was sealed in a microwave vial and heated under microwave irradiation at 150C for 2 h. The resulting mixture was partitioned between EtOAc/Water and extracted with EtOAc. The combined organics were dried over Na2SO4, filtered and evaporated. Purification by FCC, eluting with a gradient of 25-100% EtOAc in cyclohexane, gave the title compound (200 mg, 43%). LCMS (Method 3): Rt 2.30 min, m/z 250 [MH+].

Statistics shows that 82560-12-1 is playing an increasingly important role. we look forward to future research findings about 3-Amino-5-tert-butylpyrazole.

82560-12-1,Some common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, molecular formula is C7H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A5. General Method for the Synthesis of BOC-Protected Pyrazoles; 5-Amino-3-tert-butyl-N1-(tert-butoxycarbonyl)pyrazole; To a solution of 5-amino-3-tert-butylpyrazole (3.93 g, 28.2 mmol) in CH2Cl2 (140 mL) was added di-tert-butyl dicarbonate (6.22 g, 28.5 mmol) in one portion. The resulting solution was stirred at room temp. for 13 h, then diluted with EtOAc (500 mL). The organic layer was washed with water (2¡Á300 mL), dried (MgSO4) and concentrated under reduced pressure. The solid residue was triturated (100 mL hexane) to give the desired carbamate (6.26 g, 92%); mp 63-64 C.; TLC Rf (5% acetone/95% CH2Cl2); 1H-NMR (DMSO-d6) delta 1.15 (s, 9H), 1.54 (s, 9H), 5.22 (s, 1H), 6.11 (s, 2H); FAB-MS m/z ((M+H)+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-5-tert-butylpyrazole, its application will become more common.

82560-12-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82560-12-1, name is 3-Amino-5-tert-butylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of [2-(6-bromo-pyridin-2-yloxy)-ethyl]-dimethyl-amine(WO2003/082278, 500 mg, 2.00 mmol), 3-tert-butyl-lH-pyrazole-5-amine (341 mg, 2.50 mmol) and trans-N,N’-dimethyl-cyclohexane-diamine (58.0 mg,0.40 mmol) was formed in toluene (5 mL). Potassium carbonate (592 mg, 4.30mmol) was added and the mixture degassed by bubbling N2 through it.Copper(I) iodide (39.0 mg, 0.20 mmol) was added and the mixture was sealedin a microwave vial and heated using microwave irradiation at 150C for 2 h.The resulting mixture was partitioned between EtOAc/Water and extractedwith EtOAc. The combined organics were dried over Na SO4, filtered andevaporated. Purification by FCC, eluting with a gradient of 0-10% [2M NH3/MeOH] in DCM, gave the crude title compound (428 mg, 69%) as a brown oil.

The synthetic route of 82560-12-1 has been constantly updated, and we look forward to future research findings.

Adding some certain compound to certain chemical reactions, such as: 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82560-12-1. 82560-12-1

To a solution of methyl-4-iodo-2-methoxybenzoate (10.0 g, 34.2 mmol) in toluene (90 mL) was added 3-fe/f-butyl-1 H-pyrazol-5-amine (5.24 g, 37.7 mmol) followed by (1 R,2R)-/V1,/V2- dimethylcyclohexane-1 ,2-diamine (870 mg, 1 .08 mL, 6.85 mmol) and potassium carbonate (14.9 g, 108 mmol). The mixture was purged with N2, copper(l) iodide (326 mg, 1 .71 mmol) was added and the reaction mixture was heated at reflux under N2 for 18 hr. The mixture was cooled to RT and was partitioned between EtOAc (100 mL) and water (3 x 150 mL). The organic layer was separated and washed with aq. citric acid solution (1 % w/v, 150 mL) followed by water (150 mL), and was then dried and evaporated in vacuo. The residue was purified by flash column chromatography (Si02, 330 g, EtOAc in isohexane, 0-100%, gradient elution) to afford methyl 4-(5-amino-3-ie f-butyl-1 /-/-pyrazol-1 -yl)-2-methoxybenzoate as a buff coloured solid (3.62 g, 35%); Rl 1.93 min (Method 2); m/z 304 (M+H)+ (ES+).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Amino-5-tert-butylpyrazole.

82560-12-1,Some common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, molecular formula is C7H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate A15: 3-(iert-Butyl)-1-(3-(2-methoxyethoxy)phenyl)-1 H-pyrazol-5-amine. Intermediate A15 To a solution of 1-iodo-3-(2-methoxyethoxy)benzene (1.18 g, 4.05 mmol) in anhydrous toluene (7.0 mL) was added 3-(ie/f-butyl)-1 – -pyrazol-5-amine (619 mg, 4.45 mmol) followed by (1R,2f?)-A/1,/V2-dimethylcyclohexane-1 ,2-diamine (255 mu, 1.62 mmol) and potassium carbonate (1.96 g, 14.2 mmol). The mixture was purged with nitrogen, after which copper(l) iodide (77 mg, 0.41 mmol) was added and the reaction mixture heated at reflux under nitrogen for 18 hr. The resulting mixture was cooled to RT and was partitioned between EtOAc (250 mL)and water (250 mL). The organic layer was separated and was washed with water (2 x 250 mL) and brine (250 mL) and was then dried and evaporated in vacuo. The residue was purified by flash column chromatography (Si02, 120 g, 0-5% [0.7 M NH3 in MeOH] in DCM, gradient elution) to afford the title compound, Intermediate A15, as a brown gum (1.04 g, 84%); Rl 2.20 min (Method 1 , acidic); m/z 290 (M+H)+ (ES+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-5-tert-butylpyrazole, its application will become more common.

82560-12-1, Adding some certain compound to certain chemical reactions, such as: 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82560-12-1.

A solution of Intermediate 55a (2.64 g, 6.50 mmol), 3-tert-butyl-lH-pyrazole-5- amine (997 mg, 7.1 mmol) and trans-N,N-dimethylcyclohexane-diamine (185 mg, 0.33 mmol) was formed in toluene (25 mL). Potassium carbonate (1.9 g, 13.7 mmol) was added and the mixture degassed by bubbling nitrogen through it. Copper(I) iodide (64.0 mg, 1.30 mmol) was added and the mixture was refluxed at 110 C for 24 h. The solvent was evaporated under reduce pressure and the residue was partitioned between EtO Ac/Water and extracted with EtOAc. The combined organics were dried over Na2S04, filtered and evaporated. Purification by FCC eluting with a gradient of 0-50% EtOAc in cyclohexane gave the title compound (1.72 g, 64%). LCMS (Method 3): Rt 3.69 min, m/z 418 [MH+].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 82560-12-1.