Category: pyrazoles-derivatives

Taylor, Edward C. published the artcile3-Cyano-4-aminopyrazolo[3,4-d]pyrimidine, an azalog of the aglycone of toyocamycin, SDS of cas: 54385-49-8, the main research area is .

cf. CA 63, 602a. Condensation of (NC)2C:C(CN)2 with H2NC(:NH)NH2.HCl followed by hydrolysis gave a good yield of 5-aminopyrazole-3,4-dicarbonitrile (I, R = NH2) (II). Reaction of II with HC(OEt)3 under anhydrous conditions by refluxing 7 h., isolation of the intermediate I (R = N:CHOEt) (III), and treatment with alc. NH3 gave 83% yield of the desired aglycon analog (IV, R = CN) (V). III recrystallized from C5H5N-petroleum ether without special precautions against moisture gave I (R = NHCHO). V refluxed 24 h. in 10% aqueous NaOH and acidified with 9% aqueous HCl gave the acid IV (R = CO2H), sublimed in vacuo to 4-aminopyrazolo[3,4-d] pyrimidine IV (R = H). V in 8% aqueous HCl stirred at 0° with addition of aqueous NaNO2, the mixture boiled and the isolated product recrystallized gave 3-cyano-4(5H)-pyrazolo[3,4-d]pyrimidinone.

Journal of Organic Chemistry published new progress in CAplus about 54385-49-8, 54385-49-8 belongs to class pyrazoles-derivatives, name is 5-Amino-1H-pyrazole-3,4-dicarbonitrile, and the molecular formula is C5H3N5, SDS of cas: 54385-49-8.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Hasany, Syed Moosa published the artcileExtractive separation and preconcentration of divalent copper from aqueous media, Related Products of pyrazoles-derivatives, the main research area is copper preconcentration extraction; phenylmethyltrifluoroacetylpyrazolone extraction copper; pyrazolone extraction copper.

The extraction off Cu(II) with 1-phenyl-3-methyl-4-trifluoro-acetyl-5-pyrazolone (FAP) in CHCl3 was studied. Complete extraction of the metal was achieved from pH 4-6 buffers. The extractability of other elements was examined under the optimal conditions selected from Cu extraction to check the selectivity. Extracted Cu can be stripped quant. into aqueous solutions A simple and rapid separation and preconcentration procedure Cu(II) is described for anal. applications.

Radiochimica Acta published new progress about copper preconcentration extraction; phenylmethyltrifluoroacetylpyrazolone extraction copper; pyrazolone extraction copper. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Related Products of pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Tawil, Bassem F. published the artcileSynthesis of the spermidine alkaloid (±)-N(1)-acetyl-N(1)-deoxymayfoline, SDS of cas: 27412-71-1, the main research area is deoxymayfoline acetyl synthesis; mayfoline acetyldeoxy synthesis.

The total synthesis of the spermidine alkaloid (±)-N(1)-acetyl-N(1)-deoxymayfoline [(±)-I, R = Ac] was achieved by expansion of rings. The 5-membered cyclic compound II was fused with butadiene by intermol. Diels-Alder cycloaddition The resulting 7-phenyl-1,6-diazabicyclo[4.3.0]nona-3,7-dien-9-one was reductively cleaved with Raney-Ni in alc. KOH to afford the mono-cyclic lactam III (R1 = H). This was selectively alkylated in high yields to the cyano derivative III (R1 = CH2CH2CN). Reduction of the nitrile group to the amine derivative went smoothly by use of Adam’s catalyst in the presence of acid. Intramol. transamidation was then accomplished by acid catalysis to furnish the 13-membered diazalactam I (R = H). The synthesis of (±)-I (R = Ac) was completed by the selective acetylation of the more nucleophilic amino group.

Tetrahedron published new progress about deoxymayfoline acetyl synthesis; mayfoline acetyldeoxy synthesis. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, SDS of cas: 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Uzoukwu, B. A. published the artcile1-Phenyl-3-methyl-4-trifluoroacetylpyrazolone-5 as an extraction and spectrophotometric reagent for iron(III), Application In Synthesis of 1691-93-6, the main research area is iron determination extraction spectrophotometry; phenylmethyltrifluoroacetylpyrazolone reagent iron determination.

A rapid, simple and sensitive extraction method for the determination of Fe (III) spectrophotometrically in buffer solutions using 1-phenyl-3-methyl-4-trifluoroacetylpyrazolone-5 (HPMTFP) is described. The properties of the color of the extracted complex species with respect to pH of aqueous media, presence of synergists, various solvents, time and diverse ions are reported. Up to 500 ppm of Ag+, K+, Na+, Ba2+, Be2+, Ca2+, Cd2+, Co2+, Mg2+, Mn2+, Ni2+, Pb2+, Sr2+ and Zn2+ do not interfere. The tolerance level of the following ions which interfere were determined (ppm): Cu2+ â‰?20, Ce4+ â‰?8, Cr6+ â‰?100, Mo6+ â‰?8, U6+ â‰?50, V4+ â‰?300, V5+ â‰?20 and W6+ â‰?8. Beer’s law is valid up to 10 ppm Fe (III) (ε, 7.32 ± 0.08 × 103 L mol-1 cm-1) within an optimum pH range of 1.5-4.5.

Journal of the National Science Council of Sri Lanka published new progress about iron determination extraction spectrophotometry; phenylmethyltrifluoroacetylpyrazolone reagent iron determination. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Application In Synthesis of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Umetani, Shigeo published the artcileSolvent extraction of lithium and sodium with 4-benzoyl or 4-perfluoroacyl-5-pyrazolone and TOPO, Application of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is lithium extraction perfluoroacylpyrazolone; sodium extraction benzoylpyrazolone TOPO; pyrazolone acyl TOPO extraction alkali.

The synergic solvent extraction of Li+ and Na+ into C6H6 or cyclohexane with 4-benzoyl- or 4-perfluoroacyl-5-pyrazolone and trioctylphosphine oxide (TOPO) was studied. Quant. extraction (>99%) of Li+, which is one of the most poorly extractable metal ions, can be achieved with 1-tolyl-3-methyl-4-perfluoroacyl-5-pyrazolone and TOPO. The extraction of Na+ is somewhat poorer than that of Li+ under the same conditions. The perfluoroacyl group at the 4-position of the pyrazolone ring enhances the extraction and increases the maximum percentage extracted Cyclohexane is found to be suitable for a quant. extraction as an organic phase when the reagents are soluble in it. Improved separation of Li+ and Na+ can be attained when they are extracted into C6H6.

Talanta published new progress about lithium extraction perfluoroacylpyrazolone; sodium extraction benzoylpyrazolone TOPO; pyrazolone acyl TOPO extraction alkali. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Application of 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Cheema, M. N. published the artcileSynergic effect of triphenylphosphine oxide (TPPO) on the extraction of Hg(II), Se(IV), Co(II) and Mn(II) with fluorinated pyrazolone (HPMTFP), Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, the main research area is metal extraction triphenylphosphine oxide HPMTFP; cobalt extraction triphenylphosphine oxide HPMTFP; mercury extraction triphenylphosphine oxide HPMTFP; manganese extraction triphenylphosphine oxide HPMTFP; selenium extraction triphenylphosphine oxide HPMTFP.

Extraction of Hg(II) Se(IV), Mn(II) and Co(II) has been carried out with 1-phenyl-3-methyl-4-trifluoroacetyl-2-pyrazolin-5-one (HPMTFP) and triphenylphosphine oxide (TPPO) in chloroform at pH 1-10. Quant. extraction of Hg(II), Mn(II) and Co(II) at pH 4 with equimolar 0.05 M (PMTFP + TPPO) in chloroform was observed Se(IV) remains unextracted at this pH range. The stoichiometric composition of the extracted complexes M(PMTFP)2·nH2O (M = Mn, Hg), M(PMTFP)2·2TPPO (M = Mn and Co) and Co(PMTFP)2·TPPO · H2O at less than 0.1M TPPO has been established. The formation constants Km,0 and Km,n and stability constants βm,n have been computed. The anal. method developed was applied to the IAEA standard reference material potato fluor V-4 for the determination of these elements using neutron activation technique.

Journal of Radioanalytical and Nuclear Chemistry published new progress about metal extraction triphenylphosphine oxide HPMTFP; cobalt extraction triphenylphosphine oxide HPMTFP; mercury extraction triphenylphosphine oxide HPMTFP; manganese extraction triphenylphosphine oxide HPMTFP; selenium extraction triphenylphosphine oxide HPMTFP. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Recommanded Product: 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Baddar, F. G. published the artcilePhenylpropiolic acids. IX. Reaction of arylpropiolic acids with hydrazine and phenylhydrazine, Computed Properties of 27412-71-1, the main research area is phenyl propiolic acid hydrazines; propiolic acid phenyl hydrazines; acid phenyl propiolic hydrazines; hydrazines phenyl propiolic acid; pyrazolones; azines aromatic.

Phenyl-, p-chlorophenyl-, and 3,4-methylenedioxyphenylpropiolic acids react with N2H4 to give, in each case, a mixture of the corresponding pyrazol-5-one and azine. p-Methoxyphenyl- and 3,4-dimethoxy-phenylpropiolic acids give azines only. Phenyl-, p-chlorophenyl-, and m-chlorophenylpropiolic acids react with PhNHNH2 to give the corresponding 5-aryl-1-phenylpyrazol-3-ones.

Journal of the Chemical Society [Section] C: Organic published new progress about phenyl propiolic acid hydrazines; propiolic acid phenyl hydrazines; acid phenyl propiolic hydrazines; hydrazines phenyl propiolic acid; pyrazolones; azines aromatic. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Computed Properties of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zimmermann, Diane published the artcileUnambiguous synthesis of 1-methyl-3-hydroxypyrazoles, Quality Control of 27412-71-1, the main research area is pyrazolol methyl preparation.

2,3-Dihydropyrazolo[3,2-b]oxazoles were used as intermediates in a new method for preparation of 1-methyl-3-hydroxypyrazoles. Synthesis of this bicyclic system was achieved either by alkylation of 3-hydroxypyrazole with 1,2-dibromoethane or, with better yields, by cyclization of 1-tosyl-2-(2-hydroxyethyl)pyrazol-3-ones via a nitrogen to oxygen transfer of the tosyl group. Alkylation with Me trifluoromethanesulfonate followed by dihydrooxazole ring-opening with sodium iodide led to the 1-methyl-2-(2-iodoethyl)pyrazoles. Removal of the iodoethyl chain on N-2 to give the target 3-hydroxypyrazoles was achieved either via a cyanation and then a decyanoethylation reaction or via an elimination of hydrogen iodide, followed by an iodine-based oxidation of the resulting vinylic derivative Using the latter method, 1-methyl-3-hydroxypyrazoles were obtained in 58-73% yields from the corresponding 2,3-dihydropyrazolo[3,2-b]oxazoles.

Tetrahedron published new progress about pyrazolol methyl preparation. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, Quality Control of 27412-71-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Shakir, Mohammed published the artcile3,4-Dicyano-5-aminopyrazole complexes of anhydrous divalent transition metal chlorides and their triphenylphosphine derivatives, Synthetic Route of 54385-49-8, the main research area is transition metal aminocyanopyrazole complex; pyrazole dicyanoamino transition metal complex; cyanoaminopyrazole transition metal complex.

3,4-Dicyano-5-aminopyrazole (L) reacts either with anhydrous MCl2 or with [M(PPh3)2Cl2] to yield ML4Cl2 (M = Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Hg), whose monomeric and covalent natures were confirmed by their solubility in most nonpolar solvents and their low elec. conductivities. The bonding mode of substituted pyrazole is inferred from the position of the ν(C:N) band in the IR spectra. The electronic spectra and the magnetic moments of these compounds were recorded.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about transition metal aminocyanopyrazole complex; pyrazole dicyanoamino transition metal complex; cyanoaminopyrazole transition metal complex. 54385-49-8 belongs to class pyrazoles-derivatives, name is 5-Amino-1H-pyrazole-3,4-dicarbonitrile, and the molecular formula is C5H3N5, Synthetic Route of 54385-49-8.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Mao, Jiajun published the artcileSynergistic extraction of uranium(VI) with 1-phenyl-3-methyl-4-acylpyrazolone-5 and neutral extractants, Computed Properties of 1691-93-6, the main research area is uranium extraction phenylmethylacetylpyrazolone neutral extractant; dioctylsulfoxide pyrazolone extraction uranium; TOPO pyrazolone extraction uranium; TBP pyrazolone extraction uranium.

The synergistic extraction of uranium(VI) from hydrochloric acid solution with five chelating agents: 1-phenyl-3-methyl-4-benzoylpyrazolone-5 (PMBP), 1-phenyl-3-methyl-4-acetylpyrazolone-5 (PMAP), 1-phenyl-3-methyl-4-(2′-chlorobenzoyl)pyrazolone-5 (PMCBP), 1-phenyl-3-methyl-4-(p-nitrobenzoyl)pyrazolone-5 (PMNBP) and 1-phenyl-3-methyl-4-trifluoroacetylpyrazolone-5 (PMTFP) plus the neutral extractants TBP, dioctyl sulfoxide (DOSO) and TOPO in chloroform were investigated. The extraction coefficients were greater for such mixtures than the individual component. The formulas of the extracted species were determined to be UO2A2B (where HA = chelating agent, B = neutral extractant). Extraction power of these chelating agents increases as follows: PMCBP > PMNBP > PMTFP = PMBP > PMAP. Synergistic extraction power of the neutral extractants increases as follows: TOPO > DOSO > TBP. The extraction equilibrium constants were calculated The mechanism of the synergistic extraction and possible structure of the extracted species are discussed.

Journal of Radioanalytical and Nuclear Chemistry published new progress about uranium extraction phenylmethylacetylpyrazolone neutral extractant; dioctylsulfoxide pyrazolone extraction uranium; TOPO pyrazolone extraction uranium; TBP pyrazolone extraction uranium. 1691-93-6 belongs to class pyrazoles-derivatives, name is 5-Methyl-2-phenyl-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-3(2H)-one, and the molecular formula is C12H9F3N2O2, Computed Properties of 1691-93-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics