Category: pyrazoles-derivatives

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 100784-27-8, name is Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate

To a mixture of 3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide (7.0 g), 5.3 g anhydrous potassium carbonate and 50 ml of dry acetone, 2.8 g of n-butyl isocyanate was added at room temperature. The mixture was refluxed for 3 hours. (0092) After refluxing, acetone was evaporated under reduced pressure and the residue was dissolved in ice-water. After separation of a trace of water insolubles, the filtrate was acidified with hydrochloric acid and the crystals formed were filtered, washed with water and dried to obtain 5.2 g N-(n-butylcarbamoyl)-3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 31037-02-2,Some common heterocyclic compound, 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H11N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 69 Preparation of ethyl 4-Hydroxy-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo-[3,4-b]pyridine-5-carboxylate A solution of sodium metal (12.7 g, 0.55 mol) in ethanol is treated at room temperature with ethyl 5-amino-1-methyl-4-pyrazolecarboxylate (25 g, 0.148 mol), stirred for 0.5 h, treated dropwise with a solution of diethyl malonate (80 ML, 0.52 mol in ethanol over a 0.5 h period, heated at reflux temperature for 56 h, cooled to room temperature, diluted with water, washed with ethyl acetate, acidified to PH 2 with HCl and filtered.The filtercake is washed sequentially with water, ethanol, ethyl acetate and toluene and dried in vacuo at 40 C. for 16 h to afford the title product as a white solid, 28.7 g (82% yield), identified by HNMR analysis.

The synthetic route of 31037-02-2 has been constantly updated, and we look forward to future research findings.

Related Products of 578008-32-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Step 2: Synthesis of tert-Butyl 3-((4-(4-methoxy-4-(methoxycarbonyl)cyclohexyl)-6- methylpyrimidin-2-yl)amino)-5-methyl-lH-pyrazole-l -carboxylate. (0298) Methyl 4-(2-chloro-6-methylpyrimidin-4-yl)- 1-methoxycyclohexane- 1-carboxylate (70.5 mg, 0.236 mmol), tert-butyl 3-amino-5-methyl-lH-pyrazole-l-carboxylate (69.8 mg, 0.354 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-[l, -biphenyl]-2-yl)phosphine (20.0 mg, 0.2 equiv.), Pd2(dba)3 (21.6 mg, 0.1 equiv.), and potassium acetate (70 mg, 0.71 mmol) were combined in a vial under nitrogen and 0.98 mL dioxane was added. The reaction mixture was heated to 115 C for 2 h, then cooled to ambient temperature. The reaction mixture was diluted with EtOAc, filtered through celite, concentrated onto silica gel, and the resulting residue was purified by flash-column chromatography on silica gel (gradient elution, 0 to 100% ethyl acetate-hexanes) to give tert-butyl 3-((4-(4-methoxy-4-(methoxycarbonyl)cyclohexyl)-6-methylpyrimidin-2- yl)amino)-5-methyl-lH-pyrazole-l-carboxylate (48 mg, 44%) as a yellow oil. MS (ES+) C23H33N505 requires: 459, found: 460 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2820-37-3, name is 3,4-Dimethyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 3,4-Dimethyl-1H-pyrazole

5 will weigh 100mg, 0.23mmolThe pentachloroene was placed in a 25 mL two-necked flask.Drum nitrogen evacuation was repeated 3 times to obtain an anhydrous and oxygen-free reaction system.Then 7 mL of N,N-dimethylformamide was added as a reaction solvent.The reaction device is then placed in a sonicator at room temperature for 2hThe decachloromaleene is fully dispersed in N,N-dimethylformamide,At the same time weighed 68mg,2.84mmol, 20 equivalent mass fraction of 60%The sodium hydride was placed in a 25 mL two-necked flask.Drum nitrogen evacuation repeat 3In the same manner, an anhydrous and oxygen-free reaction system was obtained.Then 8 mL of N,N-dimethylformamide was added as a reaction solvent.Stir 0.5 h so that sodium hydride is fully dispersed in the solvent.Then use a syringe to extract 453mg,20 equivalents of 3,4-dimethylpyrazole are slowly injected into dispersed sodium hydride N,N-dimethylformamide.Then there are a lot of bubbles in the solution,Stirred for 0.5 h to give a clear orange solution.Then slowly add this clear orange solutionAfter ten bowl chloride ultrasound ene reaction flask,It can be seen that the color of the solution quickly turns dark green and slowly approaches blackThe reaction system was reacted overnight at 25C.After the reaction is over,Add a small amount of water slowly to quench the reaction.Then it is extracted with dichloromethane and washed continuously until the color in the aqueous phase is colorless.Then all the organic phases were collected, spin-dried and passed through a silica gel column.The light yellow ribbon is the target molecule3,4-Dimethylpyrazoleene bowlene compound, 4.4 mg,The yield was 30%

The synthetic route of 2820-37-3 has been constantly updated, and we look forward to future research findings.

Related Products of 75415-03-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75415-03-1 as follows.

General procedure: Compound 4a (2 mmol), NaH (2.4 mmol) and indole were dissolved in DMF (10 mL). The reaction mixture was stirred at room temperature for 12h before diluted with water (20 mL) and extracted with ethyl acetate (30 mL ¡Á 3). The organic layer was concentrated in vacuum. Purication by ash column chromatography gave the target product 5h.

According to the analysis of related databases, 75415-03-1, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35691-93-1, Formula: C8H12N2O2

4.2.1 Ethyl 2,5-dimethylpyrazolo[1,5-a]quinoline-3-carboxylate (5a) Condition A: A mixture of 2-fluoroacetophenone 3a (138 mg, 1.00 mmol), 1H-pyrazole 2a (202 mg, 1.20 mmol) and K2CO3 (420 mg, 3.00 mmol) in DMF (5.0 mL) was stirred at 120 C for 16 h. After monitoring the end of the reaction on TLC, the mixture was cooled to room temperature and diluted with water. The resulting mixture was extracted with ethyl acetate twice. The combined organic layers were washed with water twice, dried over MgSO4 and the solvent was removed in vacuo to afford a residue. The residue was purified by flash column chromatography (hexane:EtOAc=5:1) on silica gel to afford 5a (92.0 mg, 34% yield). Condition B: The reaction was carried out with Cs2CO3 instead of K2CO3 under the same conditions as that of Condition A to afford 5a (210 mg, 78% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 1089212-38-3, name is 4-Bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1089212-38-3, HPLC of Formula: C5H5BrF2N2

25. Preparation of N-(9-isopropylbenzonorbornen-5-yl)-3-difluoromethyl-1-methyl-pyrazole-4-carboxamide in the presence of 2,2-dimethyl-1,3-bis(diphenylphosphino)propane (Pepstar)A solution of Pd(PhCN)2Cl2 (0.0375 mmol) and Pepstar (0.1125 mmol) in dimethyl-formamide (DMF, 10 ml) was stirred at room temperature for 30 minutes. The solution comprising the pre-formed catalyst was transferred into an inertized autoclave. In a CO countercurrent, diazabicyclodecene (DBU, 16.5 mmol) and solutions of 3-difluoro-methyl-1-methyl-4-bromopryazole (16.5 mmol) and 5-amino-9-isopropylbenzo-norbornene (15 mmol) in DMF (in each case 25 ml) were added to the solution of the catalyst in the autoclave. The reaction mixture was stirred at 150 C. and a CO pressure of 15 bar for 24 h.The conversion based on the bromopyrazole was almost quantitative, at a selectivity of 38%. The composition of the reaction discharge was, according to GC analysis, as follows: DMF 73.8 area %, bromopyrazole 0.02 area %, DBU 8.2 area %, amino-isopropylbenzonorbornene 7.1 area % and N-(9-isopropylbenzonorbornen-5-yl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide 4.08 area %.Work-up was carried out as described in example 2.i), giving an isolated yield of N-(9-isopropylbenzonorbornen-5-yl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide of 38%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Application of 863548-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 863548-52-1, name is (1-Methyl-1H-pyrazol-5-yl)methanamine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of C-(2-methyl-2H-pyrazol-3-yl)-methylamine (78 mg, 0.7 mmol) in dioxane (30 mL) was added 4-phenoxycarbonylamino-benzoic acid ethyl ester (200 mg, 0.7 mmol) and TEA (213 mg, 2.1 mmol). After stirred at 90 C overnight, the reaction mixture was concentrated in vacuum. The residue was purified by pre-HPLC to afford ethyl 4-(3-((1-methyl-1H-pyrazol-5- yl)methyl)ureido)benzoate (45 mg, 21%) as a white solid. ?H NIVIR (400 IVIHz, CD3OD): oe = 7.91 (d, J= 8.8 Hz, 2H), 7.49 (d, J= 8.4 Hz, 2H), 7.36 (d, J= 1.6 Hz, 1H), 6.24 (d, J= 1.6 Hz, 1H), 4.47 (s, 2H), 4.32 (q, J= 7.2 Hz, 2H), 3.87 (s, 3H), 1.37 (t, J= 7.2 Hz, 3H). MS: m/z 303.0 (M+H).

The synthetic route of (1-Methyl-1H-pyrazol-5-yl)methanamine has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H9N3O2

Cs2CO3 (64.20 g, 197.20 mmol) was added to a solution of ethyl 5-amino-1H-pyrazole- 4-carboxylate (20.40 g, 131.40 mmol) and ethyl-3-ethoxyacrylate (28.6 mL, 197.20 mmol) in DMF (250 mL). The reaction mixture was stirred at 110 ¡ãC for 16 h. The mixture was cooled to room temp and the pH was adjusted to 4 by the addition of AcOH (80 mL). The mixture was concentrated in vacuo and the residue partitioned between CH2Cl2 H2O (1000 mL, 1:1). The organic layer was separated and the aqueous layer was extracted with CH2Cl2 (3 X 500 mL). The combined organics were washed with brine, dried (MgS04) and concentrated. The crude residue was suspended in EtOH (300 mL) and heated to boiling. After cooling to room temperature the solid was collected by filtration, rinsed with EtOH, then Et20 and dried under vacuum to give ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (25.16 g, 92 percent). MS (ESI) calcd for C9H9N3O3 (m/z): 207.06; found: 208 [M+H]

According to the analysis of related databases, 1260243-04-6, the application of this compound in the production field has become more and more popular.

Electric Literature of 132712-71-1, A common heterocyclic compound, 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound (M-32) (1.00 g, 10.2 mmol)And potassium carbonate (4.23 g, 30.6 mmol)Was dissolved in acetonitrile (30 mL)1,4-dibromobutane (2.64 g, 12.2 mmol) and the mixture was stirred for 12 hours at 50 C.. Thereafter, water was added,And extracted with ethyl acetate.After drying the organic layer with anhydrous sodium sulfate,After filtration, the solvent was distilled off under reduced pressure condition.The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate)To obtain a compound (M-34).

The synthetic route of 132712-71-1 has been constantly updated, and we look forward to future research findings.