Category: pyrazoles-derivatives

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2458-26-6 as follows. Formula: C9H8N2

Aromatic substrate 1b (0.1mmol), 3-phenylpyrazole 2m (0.15mmol), cuprous bromide (0.1mmol), potassium acetate (0.2mmol), DMSO (1.0mL) were added to the 15mL Schlenk tube, then directly sealed tube at 85 C for 12h. After the reaction was completed, the mixture was cooled to room temperature, and a small amount of ethyl acetate and ammonia were added to quench the reaction. The ethyl acetate was repeatedly extracted. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered under reduced pressure, and the solvent was evaporated under reduced pressure. The crude product was separated and purified by a preparative plate (DCM: MeOH = 35: 1) to obtain 3bm as a white solid, 29.4 mg, with a yield of 70%.

According to the analysis of related databases, 2458-26-6, the application of this compound in the production field has become more and more popular.

Reference of 119083-00-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 119083-00-0, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of tert-butyl (3S,4R)-4-amino-3-(4-fluorophenyl)piperidine-1-carboxylate (275 mg), 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (236 mg), HATU (497 mg), triethylamine (0.3 mL) and DMF (4 mL) was stirred at room temperature for 15 hours. The reaction mixture was diluted with a saturated aqueous solution of sodium bicarbonate, followed by extraction with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (403mg). MS: [M-H]- 469.3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Related Products of 402-61-9, These common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step C N-r(4i?V6-(4-Chlorophenvn-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H- pyrano|”2,3-61pyridin-4-yl]-5-methyl-l.H-pyrazole-3-carboxamide.; A mixture of the product of Step B (300 mg, 0.69 mmol), S-methylpyrazole-S-carboxylic acid (105 mg, 0.83 mmol), PyBOP (540 mg, 1.04 mmol), and NEt3 (0.19 mL, 1.38 mmol) in 20 mL of CH2Cl2 was stirred at rt. After 16 h, the reaction mixture was diluted with Et2O (50 mL), washed with saturated aq NaHCO3 (3×50 mL) and brine (3×50 mL). The organic layer was separated, dried over MgSO4 and concentrated. Chromatography on a Biotage 40+S cartridge using 1 : 1 v/v EtOAc/Hexanes as the eluant afforded the title compound: 1H NMR delta 1.44 (s, 3H), 1.51 (s, 3H), 1.94 (t, J= 12.5, IH), 2.26-2.30 (m, 4H), 5.62 (m, IH), 6.58 (s, IH), 6.96 (d, J= 8.5, 2H), 7.12-7.29 (m, 5H), 7.69 (s, IH).

Statistics shows that 5-Methyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 402-61-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5744-59-2, name is 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H8N2O2

Example 2N-((ls,4s)-4-(l,5-dimethyl-lH-pyrazole-3-carboxamido)cyclohexyl)-5-fluoro-2-(4′- hydroxy-2′-(morpholinomethyl)biphenyl-3-yloxy)nicotinamide Step (a) N-((ls,4s)-4-(l,5-dimethyl-lH-pyrazole-3-carboxamido)cyclohexyl)-5-fluoro-2- (3-iodophenoxy)nicotinamideTo a solution of l,5-dimethyl-lH-pyrazole-3-carboxylic acid (0.123 g, 0.88 mmol) in dry DMF (10 mL) was added DIPEA (0.460 mL, 2.64 mmol) followed by HATU (0.334 g, 0.88 mmol). The mixture was allowed to stir for 10 min at RT. To this mixture was added N- ((ls,4s)-4-aminocyclohexyl)-5-fluoro-2-(3-iodophenoxy Nicotinamide (0.40Og, 0.88 mmol) and the mixture stirred overnight, poured onto water and the crude product collected by filtration, dried and used in step (c) without purification. [M+H]+ =577 (MultiMode+)

According to the analysis of related databases, 5744-59-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 13745-59-0, These common heterocyclic compound, 13745-59-0, name is 3-Bromo-1,4-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 246.la (lOg, 3.36mmol, 1.Oeq) and 3-bromo-1,4-dimethyl-1H-pyrazole (0.58g, 3.36mmol, 1.Oeq) in mixture of 1,4-dioxane (8.OmL) and water (2.OmL), potassium carbonate (1 .24g, 9.O2mmol, 2.5eq) was added. Argon waspurged through the reaction mixture for 5 mm. Then, [1,1?-bi s(diphenylphosphino)ferrocene] dichloropalladium(II) complex with CH2C12 (0 .29g, 0.33 mmol, 0. leq) was added and again purged for 5 mm. Reaction mixture was stirred at 110 C for 2h. After completion of the reaction, the reaction mixture was transferred to water and extracted with ethyl acetate. Organic layers were combined, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to get the crude material. This was purified by column chromatography using 12% ethyl acetate in hexane as eluant to obtain 246.1 (0.6g, 39.35%). MS(ES): m/z 266.38 [M+H]t

Statistics shows that 3-Bromo-1,4-dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 13745-59-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-09-5, name is 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 25016-09-5

Step 3: Preparation of 3-(2,5-dimethyl-2H-pyrazole-3yl)-2-(4-fluoro phenyl) acrylic acid (16) A mixture of compound 15 (1 gram, 8.0 mmol) and 4-fluorophenyl acetic acid (1.24 grams, 8.0 mmol), acetic anhydride (2 mL) and triethylamine (0.84 mL, 6.0 mmol) was refluxed under nitrogen atmosphere for 5-6 h. The excess of acetic anhydride was distilled out at the same temperature. The mixture was then diluted with water (100 mL) and neutralized with 2N hydrochloric acid. The solid precipitated was filtered and dried under vacuum to afford the title compound 3-(2,5-dimethyl-2H-pyrazole-3yl)-2-(4-fluoro phenyl) acrylic acid (16) 1.4 gram as a pale brown solid. Yield: 67%; 1H NMR (200 MHz, DMSO-d6): delta 12.75 (s, D2O exchangeable) 7.66 (s, 1H), 7.26-7.12 (m, 4H), 5.0 (s, H) 3.84 (s, 3H), 2.05 (s, 3H); Mass (CI method, i-butane): 261 (M+1, 80%); IR: numax (KBr, cm-1): 3440, 1695.

According to the analysis of related databases, 25016-09-5, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 27258-33-9

General procedure: To the solution of 45.0 g aldehyde 10 (0.363 mol) in 225 cm3 pyridine, 45.4 g malonic acid (0.436 mol) and 0.900 g piperidine (10.9 mmol) were added. The resulting mixture was heated at 70 C for 3 days. The solvent was removed in vacuo, and the residue was triturated with H2O. The precipitate was filtered to give the product 11

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27258-33-9.

Electric Literature of 23170-45-8, These common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N2 protection,Methyl-1H-pyrazole-4-carboxylate (0.14 g, 1.0 mmol), CuI (19.1 mg,(0.2 mmol), III5 (0.34 g, 1.2 mmol), (E) -N, N’-dimethyl-1,2-cyclohexylenediamine (28.5 mg, 0.2 mmol) And DMF (3 mL) were added to a 25 mL two-necked flask and reacted at 110 C for 24 h,Cooled to room temperature, diluted with 10 mL of water, extracted with ethyl acetate (15 mL x 3), washed with saturated brine (10 mL), dried over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure,Silica gel column (V ethyl acetate: V petroleum ether = 4: 1),(0.10 g) of methyl orange 1- (3′-nitro-4′-morpholine-phenyl) -3-methyl-pyrazole-4-carboxylate (IV5)Yield 46.2%.

Statistics shows that Methyl 3-methyl-1H-pyrazole-4-carboxylate is playing an increasingly important role. we look forward to future research findings about 23170-45-8.

Synthetic Route of 25711-30-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25711-30-2, name is 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1,5 -Dimethyl- leta-pyrazole-4-carbaldehyde (114 mg, 0.92 mmol) was added to a solution of tert-butyl 2-[(4-piperidin-4-ylbenzoyl)amino]phenylcarbamate (289 mg, 0.73 mmol) in dichloromethane (6 ml) followed by acetic acid (50 mul, 0.87 mmol). The reaction mixture was allowed to stir under nitrogen for 2.5 hours. Sodium triacetoxyborohydride (233 mg, 1.10 mmol) was added and the reaction mixture allowed to stir, at ambient temperature, for 18 hours (overnight). Saturated aqueous sodium bicarbonate solution (10 ml) was then added to the reaction and allowed to stir for 15 minutes. The organic phase was separated and the aqueous phase re-extracted with dichloromethane (10 ml). The combined organics were washed with water, dried over magnesium sulphate and evaporated to dryness to afford the product as a colourless gum (308 mg, 84%), which was used without further purification; Mass Spectrum: M+H+ 504.

The synthetic route of 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Reference of 37622-90-5, These common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of ethyl 1H-pyrazole-4-carboxylate (L, 4 g; 28.5 mmol) in tetrahydrofuran(50 ml) was added sodium hydride (1.36 g, 28.5 mmol) at 0C. The reaction mixture wasstirred for 1 h. Methyl iodide (6.07 g, 42.8 mmol) was added and the reaction was stirred for 18h at room temperature. The reaction mixture was concentrated under reduced pressure anddiluted with water. The resulting aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with sodium bicarbonate, brine, dried over Na2SO4, filtered and concentrated under vacuum to afford ethyl 1-methyl-i H-pyrazole-4-carboxylate as a yellow liquid (LI; 3.5 g, 77% yield). ?H NMR (400 MHz, CDC13): 7.88 (s, 1H), 7.85 (s, 1H), 4.3110 4.25 (q,J= 7.2 Hz, 2H), 3.9 (s, 3H), 1.35-1.31 (t,J= 7.2 Hz, 3H). MS (M+i) 155.12.

Statistics shows that Ethyl 4-pyrazolecarboxylate is playing an increasingly important role. we look forward to future research findings about 37622-90-5.