Category: pyrazoles-derivatives

Related Products of 402-61-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 402-61-9 name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

23.3 g (0.121 mol) of EDC, 16.4 g (0.121 mol) of HOBt and 26.7 g (0.121 mol) of N’-hydroxy-4-(trifluoromethoxy)benzenecarboximide amide were added successively to a solution of 15.3 g (0.121 mol) of 5-methyl-1H-pyrazole-3-carboxylic acid in 600 ml of anhydrous DMF at RT. The mixture was stirred first at RT for 2 h and then at 140 C. for 5 h. After cooling, the mixture was diluted with 2 litres of water and extracted three times with 1 litre of ethyl acetate each time. The combined organic extracts were washed successively with water and saturated sodium chloride solution. After drying over anhydrous magnesium sulphate, the mixture was filtered and the solvent was removed on a rotary evaporator. The crude product obtained was purified by means of filtration with suction over a suction filter filled with silica gel (eluent: cyclohexane/ethyl acetate 5:1?1:1). The product fractions were combined and the solvent was removed on a rotary evaporator to such an extent that the product just started to precipitate out. The precipitation was brought to completion at RT. By filtration and further concentration of the mother liquor, two fractions of solid were obtained, which were combined and dried under a high vacuum. 19.7 g (52% of th.) of the title compound were obtained in total in this way.1H-NMR (400 MHz, CDCl3, delta/ppm): 10.75 (broad, 1H), 8.24 (d, 2H), 7.34 (d, 2H), 6.81 (s, 1H), 2.46 (s, 3H).HPLC (method A): Rt=4.72 min.MS (DCI, NH3): m/z=311 [M+H]+.LC/MS (method F, ESIpos): Rt=1.27 min, m/z=311 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 400877-57-8, name is Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate

A solution of 1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid methyl ester (4.8 g, 25.94 mmol) in dry MeOH (100 ml) was thoroughly purged with argon, treated with 10% Pd-C (2.7 g, 2.59 mmol), and again purged with argon. Then the reaction mixture was hydrogenated under a balloon pressure of hydrogen at rt for overnight. The reaction mixture was filtered through a bed of celite. The filtrate was concentrated and dried to give the title compound as gray – whitesolid (3.4 g, 84%), which was used in the next reaction step without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3112-31-0, Product Details of 3112-31-0

(2R,4R)-4-Amino-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester (HCl salt; 108 mg, 286 mummol, 1.0 eq.), 3,5-pyrazoledicarboxylic acid (66.9 mg, 429 mumol, 1.5 eq.), and HATU (160 mg, 430 mumol, 1.5 eq.) were combined in DMF (5 mL), and the resulting mixture was stirred for 2 minutes. DIPEA (150 muL) was added and the mixture was stirred for 1 hour. The mixture was dried under vacuum, and the product was purified using reverse phase chromatography to yield the title compound as a TFA salt (60 mg; purity 98percent). MS m/z [M+H]+ calc’d for C26H29N3O6, 480.21. found 480.4).

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Reference of 2458-26-6, The chemical industry reduces the impact on the environment during synthesis 2458-26-6, name is 3-Phenyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

EXAMPLE 154; Step 1; 1-(4-Methoxy-benzyl)-3-phenyl-1H-pyrazole; A mixture of 3-phenyl-1H-pyrazole (1.35 g, 9.36 mmol), 4-methoxybenzyl chloride (1.5 g, 9.7 mmol) and K2CO3 (3.3 g, 24.2 mmol) in methyl ethyl ketone was refluxed for 24 h. The salts were filtered off, and the solvent was removed in vacuo. The residue was purified by a column chromatography on silica gel to yield the title compound (2.2 g, 89%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 27069-16-5, A common heterocyclic compound, 27069-16-5, name is 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C11H10N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of oximic acid (4a-k, 3.6 mmol in 50 mL THF) was added HOBt (3.6 mmol) in an ice-cooled bath. Next, a mixture of cystamine dihydrochloride (1.8 mmol) and TEA (1 mL) in DMSO (6 mL) were added, followed by the addition of EDCI (4.0 mmol). After stirring for 24 h at room temperature, the reaction was quenched with water and extracted with EtOAc (60 mL × 3). The combined organic extracts were washed with brine (50 mL), dried over MgSO4 and then evaporated. The resulting residue was then purified by column chromatography on silica gel as indicated.

The synthetic route of 27069-16-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 632365-54-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 632365-54-9, name is Methyl 5-amino-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Under argon, lithium borohydride (2M in THF, 84.2 ml) was added dropwise to a stirred solution of methyl 5-aminopyrazole-3-carboxylate (9.5 g) in tetrahydrofuran (300 ml). The resultant mixture was heated to reflux for 16 hours. The mixture was cooled and methanol was added dropwise to quench residual reducing agent. The mixture was evaporated. Methanol (200 ml) was added to the residue and insoluble salts were removed by filtration. The filtrate was evaporated and the residue was purified by column chromatography on silica using a solvent gradient of 9:1 to 4:1 of methylene chloride and methanol as eluent. There was thus obtained 3-amino-5-hydroxymethyl-li?-pyrazole (5.6 g) 1H NMR: (DMSOd6) 4.27 (s, 2H)5 4.3-5.2 (2 br s, 3H), 5.29 (s, IH).

The chemical industry reduces the impact on the environment during synthesis Methyl 5-amino-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.

Synthetic Route of 92525-10-5, The chemical industry reduces the impact on the environment during synthesis 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

A mixture of 5-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)-1-((2-(trimethylsilyl)- ethoxy)methyl)-1H-1,2,4-triazole-3-thiol (Intermediate B9) (230 mg, 417.01 mumol, 1 eq), 3-iodo-1-methyl-1H-pyrazole (86 mg, 417.01 mumol, 1 eq), CuI (158 mg, 834.02 mumol, 2 eq) and N,N’-dimethylethane-1,2-diamine (735 mg, 8.34 mmol, 20 eq) in dioxane (4 mL) was stirred at 70C under N2atmosphere for 2 hours. The reaction mixture was poured into water (10 mL) and extracted with EtOAc (3 × 10 mL). The organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by prep-TLC (SiO2, petroleum ether: ethyl acetate, 1:1) to give the title compound (170 mg, 82.7% yield, 98% purity on LCMS) as a yellow solid.1H NMR (400 MHz, CDCl3): d 7.34 (d, 1H), 6.94 (s, 1H), 6.47 (d, 1H), 6.18 (s, 1H), 5.31 (s, 2H), 3.90 (s, 3H), 3.61 (t, 2H), 2.87 (t, 4H), 2.69 (t, 4H), 2.09-2.00 (m, 4H), 1.00- 0.88 (m, 2H), 0.02 (s, 9H).LCMS: m/z 483.2 (M+H)+(ES+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83-10-3, Product Details of 83-10-3

Step 1 ) N-(3-fluoro-4-hvdroxyphenyl)- 1 ,5-dimethyl-3 -oxo-2-phenyl-2,3 -dihydro- 1H- pyrazole-4- carboxamide [0193] To a suspension of 4-amino-2-fluorophenol (2.54 g, 20 mmol) and 1,5- dimethyl-3 -oxo-2- phenyl-2,3 -dihydro- lH-pyrazole-4-carboxylic acid (4.74 g, 20.4 mmol) in DCM (60 mL) were added EDCI (4.6 g, 24 mmol) and HOAT (0.54 g, 4 mmol). The reaction was stirred at 45 C for 12 hours, then cool to rt, quenched with H20 (10 mL), and stirred for another 4 hours. The solid was obtained by filtration and washed with DCM (20 mL x 3), then dried at 60 C in vacuo for 12 hours to give the title compound as a pale yellow solid (6.37 g, 93.4%). MS (ESI, pos. ion) m/z: 342.1 [M+H]+; NMR (400 MHz, DMSO-i): delta (ppm) 10.59 (s, 1H), 9.58 (s, 1H), 7.64 (dd, J= 2.4 Hz, 13.5 Hz, 1H), 7.60 (m, 2H), 7.50 (m, 1H), 7.42 (m, 2H), 6.97 (m, 1H), 6.88 (dd, J= 9.6 Hz, 8.8 Hz, 1H), 3.34 (s, 3H), 2.70 (s, 3H).

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These common heterocyclic compound, 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H8N2O

At room temperature, add 1,3-dimethyl-1H-pyrazole-5-ol (1.12 g, 0.01 mol),(3.95 g, 0.05 mol) pyridine was sequentially dissolved in 20 ml of dichloromethane. The low temperature bath was cooled to 3 C.To the above mixture, 7-chloro-3-(methylsulfonyl)quinoline-8-carbonyl chloride (6.08 g, 0.02 mol) was added dropwise at a dropping rate of 2 drops per 30 seconds.After the dropwise addition was completed, the mixture was naturally warmed to room temperature and reacted for 5 hours. To the reaction mixture was added 10 ml of a saturated aqueous sodium hydrogen carbonate solution, and dichloromethane (3 * 15 ml) was extracted. The organic layers were combined, washed with water (1 * 15 ml), washed with saturated brine, and dried over anhydrous magnesium sulfate.The product was desolvated under reduced pressure to obtain 3.03 g of the product with a yield of 80%.

The synthetic route of 1,3-Dimethyl-1H-pyrazol-5-ol has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 30169-25-6, name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., Product Details of 30169-25-6

3,6-Bis-(3,5-dimethyl-pyrazol-1-yl)-1,2,4,5-tetrazine (1)(4:05 g 15:0 mmol) and 1H-imidazole (2:35 g 35:0 mmol)were suspended in 25 mL acetonitrile and the mixture refluxed for 3 h. After cooling the resulting precipitate was filtered and washed with large amounts of water(1 L), followed by acetonitrile and dichloromethane. 2:69 g (12:6 mmol 84%) of 5 was isolated as an orange powder. – Elemental analysis (C8H6N8, 214.19) exp. (calcd.)in %: C 44.90 (44.86),N 52.03 (52.32), H 2.90 (2.82).- DSC (5 C min1) : Tdec:: 200 C (onset). – 1H NMR([D6]DMSO, 25 C, ppm): d =7.35 (m, 1H, C-H), 8.16 (m,1H, C-H), 8.81 (m, 1H, C-H). – 13C NMR ([D6]DMSO,25 C, ppm): d =117.1 (1C), 121.5 (1C), 132.4 (1C), 153.1(1C). – Raman: n (cm-1)=3158 (10), 3126 (5), 3113 (10),1912 (5), 1537 (7), 1500 (8), 1490 (100), 1407 (13), 1372(2), 1318 (13), 1282 (7), 1254 (2), 1129 (5), 1091 (16), 1048(4), 962 (54), 895 (5), 858 (3), 801 (33), 747 (2), 665 (3), 613 (2). – IR (25 C, ATR): n (cm1)=3155 (w), 3122 (w), 3110(w), 1775 (vw), 1702 (vw), 1648 (vw), 1614 (vw), 1531 (w),1522 (w), 1475 (s), 1366 (w), 1321 (s), 1301 (m), 1260 (m),1233 (w), 1214 (m), 1153 (w), 1104 (m), 1068 (m), 1038(vs), 971 (s), 946 (s), 926 (m), 898 (s), 854 (vs), 762 (vs),693 (w).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.