Category: pyrazoles-derivatives

Synthetic Route of 92933-47-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 3 (R)-N-(1-(3-isopropyl-1H-pyrazole-5-carbonyl) pyrrolidin-3-yl)cyclopro pane carboxamide To a solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (220 mg, 1.43 mmol) in DMF (5 mL) was added HATU (690 mg, 1.82 mmol) and DIPEA (0.7 mL, 0.39 mmol) at room temperature. The reaction mixture was stirred for 30 mm and then (R)-N-(pyrrolidin-3-yl) cyclopropanecarboxamidehydrochloride (200 mg, 1.30 mrnol) was added and the mixture was stirred for another 2 his. Thenthe mixture was filtered and purified by preparative HPLC to give desired product (136.8 mg, 36%yield). ?HNMR (400 MHz, CD3OD) 6 6.48 (s, 111), 4.41 – 4.38 (m, IH), 4.03 – 3.75 (m, 4H), 3.05 -3.02 (m, IH), 2.20-2.15 (m, 11-I), 1.97 1.96 (m, 1H), 1.59- 1.57 (m, IH), 0.86-0.82 (m, 2H),0.75 – 0.73 (m, 2H). LCMS (ESI) mlz: 291.1 [M+Hj, RT = 0.687 mm (LCMS Method E).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Isopropyl-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference of 31037-02-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 31037-02-2 name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The ligand, L (0.169 g; 1 mmol), was dissolved in hot MeOH (5 cm3), and CuBr2 (0.11 g; 0.5 mmol) was added. Two days later, the brown needle-like microcrystals were filtered and washed with MeOH and Et2O. Yield: 0.143 g (54%). Calcd.(Found) for CuC14H22N6Br2: C, 29.93; H, 3.92; N, 14.96. (C,29.79; H, 3.93; N, 14.94). IR bands [ v/cm-1]: 3488, 3441,3348, 1683, 1632, 1557, 1458, 1124, 773. Molar conductivity, LambdaM (S cm2 mol-1): 61 (DMF).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.

Electric Literature of 100114-57-6,Some common heterocyclic compound, 100114-57-6, name is 3-Cyclopropyl-1H-pyrazole, molecular formula is C6H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooling (0 C) solution of 3-cyclopropyl-lH-pyrazole (1.5 g, 13.89mmol) in concentrated H2S04 (20 mL, 98%) was added concentrated HNO3 (20 mL, 65%) over 2 min. The reaction mixture was stirred over 1 hr at this temperature. It was then diluted with ice-water and extracted with EA (30 mL X 4). The organic phase was combined and washed with saturated sodium bicarbonate (50 mL). It was dried over Na2S04 and concentrated in vacuo to give a crude product (1.5 g, 70%). This crude product was pure enough to be delivered or used to the next step reaction. MS: [M+H]+ 154. 1H MR (500 MHz, CDC13) delta 0.97 (m, 2H), 1.22(m, 2H), 2.66 (m, 1H), 8.20(s, 1H), 8.38 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Cyclopropyl-1H-pyrazole, its application will become more common.

Reference of 35344-95-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To the stirred solution of tert-butyl 2, 6-dimethyl -4-methylsulfonyloxy-piperi dine- 1 – carboxylate 24-2 (400.0 mg, 1.30 mmol) in DMF (3.5 mL) was added cesium carbonate (847.92 mg, 2.60 mmol) and lH-pyrazole-4-carbaldehyde 3 (125.03 mg, 1.30 mmol). The reaction mixture was heated at 70C for 16 hours. The reaction mixture was diluted with ethyl acetate, water and brine solution. The organic fraction was separated, dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain the crude compound purified by flash chromatography using (0-30 % ethyl acetate-hexane) to afford tert-butyl 4-(4-formylpyrazol-l- yl)-2, 6-dimethyl-piperidine- 1 -carboxylate 24-4 (200.0 mg, 650.65 umol, 50.00% yield) as off white solid. LC MS: ES+ 308.3.

The synthetic route of 1H-Pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35277-02-2, name is 4-Fluoro-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Fluoro-1H-pyrazole

To a solution of 4-fluoro-pyrazole (0.10 g, 0.001162 mol) in anhydrous THF (10 mL) , which was cooled in an ice water bath under an argon atmosphere, was added sodium hydride (60% dispersion in oil, 0.14 g, 0.003486 mol). After addition, the resulting mixture was stirred for three hours. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide (1056) (0.31 g, 0.001162 mol) was added to above solution, and the resulting reaction mixture was allowed to stir overnight at room temperature under argon. The reaction was quenched by water, extracted with ethyl acetate. The organic layer was washed with brine, dried with MgSO4, filtered, and concentrated under vacuum.The product was purified by a silica gel column using hexanes and ethyl acetate (2:1 to 1:1) as eluent to afford 0.37 g (90%) of the titled compound as a yellowish solid.1H NMR (400 MHz, DMSO-d6) d 10.38 (s, 1H, NH), 8.47 (d, J = 2.0 Hz, 1H, ArH), 8.24 (dd, J = 8.8 Hz, J = 2.0 Hz, 1H, ArH), 8.10 (d, J = 8.8 Hz, 1H, ArH), 7.74 (d, J = 4.4 Hz, 1H, Pyrazole- H), 7.41 (d, J = 4.0 Hz, 1H, Pyrazole-H), 6.31 (s, 1H, OH), 4.39 (d, J = 14.0 Hz, 1H, CH), 4.21 (d, J = 14.4 Hz, 1H, CH), 1.34 (s, 3H, CH3).Mass (ESI, Negative): [M-H]-; (ESI, Positive): [M+Na]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C14H19N3

A solution of (5) (760 mg, 3.31 mmol) in DCM (2.0 mL) was added dropwise over 1.5 hr to a suspension of CDI (537 mg, 3.31 mmol) in DCM (2.0 mL) under nitrogen and the solution was stirred at RT for 1 hr. A solution of the naphthylamine (61) (1.00 g, 2.21 mmol) in DCM (4.0 mL) was added in a single portion and the solution was stirred for 16 hr, during which time a precipitate formed. The reaction mixture was taken up in DCM (10 mL) and purified by flash column chromatography (SiO2, 80 g, 20-80% EtOAc in isohexane, gradient elution) to afford tert-butyl 4-(1-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl oxy)-2-methylpropan-2-yl)pyridin-2-ylcarbamate (62) (780 mg, 52%): m/z 663 (M+H)+ (ES+)

According to the analysis of related databases, 285984-25-0, the application of this compound in the production field has become more and more popular.

Related Products of 52222-73-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step C: 3-methyl-1-(6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-yl)butan-1-one To a solution of 1-(6-chloropyridin-3-yl)-3-methylbutan-1-one (1.0 g, 5.1 mmol) and 4-(trifluoromethyl)-1H-pyrazole (766 mg, 5.62 mmol) in anhydrous DMF (20 mL) was added potassium carbonate (2.12 g, 15.3 mmol). The mixture was stirred at 50 C. for 6 h. The reaction mixture was poured into brine (30 mL) and extracted with ethyl acetate (30 mL*2). The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude residue was purified by silica gel chromatography to give 3-methyl-1-(6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-yl)butan-1-one (1.4 g) as a colorless solid. 1H NMR (400 MHz, CDCl3) delta 8.92 (d, J=2.0 Hz, 1H), 8.85 (s, 1H), 8.33 (dd, J=2.0, 8.4 Hz, 1H), 8.02 (d, J=8.4 Hz, 1H), 7.88 (s, 1H), 2.79 (d, J=6.8 Hz, 2H), 2.31-2.21 (m, 1H), 0.96 (d, J=6.8 Hz, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 5334-39-4

A mixture of 3-methyl-4-nitro-lH-pyrazole (1.36 g, 10.71 mmol), tert-butyl-4- iodopiperidine-l-carboxylate (10.00 g, 32.14 mmol) and K2CO3 (2.96 g, 21.42 mmol) in DMF (16.6 mL) was stirred at reflux for 24 h. The reaction mixture was diluted with EtOAc and water and the layers were separated. The organic layer was washed with brine, dried over MgS04, filtered and was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (irregular SiOH 40 muiotaeta, 80 g, mobile phase: heptane/DCM, gradient from 50:50 to 0: 100). The pure fractions were combined and the solvent was evaporated to give a mixture of intermediate 349 and intermediate 349′ (540.00 mg, 16% yield). intermediate 350 intermediate 350′ At 0C, HC1 (4M in dioxane) (15.00 mL, 60.00 mmol) was added to a solution of a mixture of intermediates 349 and 349′ (0.54 g, 1.74 mmol) in 1,4-dioxane (4 mL). The reaction was stirred at rt overnight. The solvent was evaporated until dryness. The residue was taken up into DCM and basified with a 10% aqueous solution of K2C03. The organic layer was dried over MgS04, filtered and the solvent was evaporated until dryness. The residue (817 mg) was purified by column chromatography on silica gel (stationary phase: irregular SiOH, 15-40 muiotaeta, 40 g, mobile phase: 98% DCM, 2% MeOH (+ 10% NH4OH) to 95% DCM, 5% MeOH (+10% NH4OH)). The pure fractions were collected and the solvent was evaporated until dryness to give 0.480 g of a mixture of intermediates 350 and 350′ used as it for the next step.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 956951-01-2, name is 3-Nitro-1H-pyrazole-1-ethanol, molecular formula is C5H7N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H7N3O3

A solution of 3-nitropyrazole (300mg, 2.65mmol), potassium carbonate (2eq) and 2- bromoethanol (l . leq) in acetonitrile (lOmL) was heated at 60C for 18h. After cooling to rt the mixture was diluted with EtOAc and washed with H20. The organic phase was collected, dried (hydrophobic frit) and concentrated in vacuo. The crude residue was dissolved in methanol (lOmL), palladium on carbon (50mg) was added and the reaction was stirred under a balloon of hydrogen for 18h. The resulting mixture was filtered through Celite and the filtrate concentrated in vacuo to give 2-(3-amino-lH-pyrazol-l-yl)ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 956951-01-2, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Ethyl 4-pyrazolecarboxylate

To a suspension of LAH (45.2 mL, 45.2 mmol, 1M in THF) in a flame-driedRBF was added a solution of ethyl 1H-pyrazole-4-carboxylate (3.17 g, 22.6 mmol) inTHF (20 mL) dropwise at 0 °C. The reaction was gradually warmed up to rt and stirred atrt overnight. The reaction mixture was cooled in an ice bath and carefully quenched bysequential dropwise addition of 1.36 mL H20, and 10 mL of 1MNaOH, then stirred 20 mm. Solid Mg504 was added, the ice bath was removed, and stirring was continued for 30 mm at room temp. Solids were removed by filtration through CELITE® and washed with THF, then MeOH. The combined filtrate was evaporated to give (1H-pyrazol-4-yl)methanol (1.75 g, 78.9percent), as a white solid. ?HNMR(500MF-Tz, DMSO-d6)oe 12.58(br. s., 1H), 7.58 (s, 1H), 7.40 (s, 1H), 4.74 (t, J=5.5 Hz, 1H), 4.37 (d, J=5.2 Hz, 2H).

According to the analysis of related databases, 37622-90-5, the application of this compound in the production field has become more and more popular.